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hSMG-1 inhibitor 11j

14 Cited Publications
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Based on 14 publication(s) in Google Scholar

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.

For research use only. We do not sell to patients.

  • Purity: 99.82%
  • CAS No.: 1402452-15-6
  • Formula: C27H28ClN7O3S
  • Molecular Weight:566.07
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • hSMG-1 inhibitor 11j Chemical Structure
    hSMG-1 inhibitor 11j Chemical Structure
  • Experimental Validation Results for hSMG-1 inhibitor 11j
  • Experimental Validation Results for hSMG-1 inhibitor 11j
  • Experimental Validation Results for hSMG-1 inhibitor 11j
  • Experimental Validation Results for hSMG-1 inhibitor 11j
  • Experimental Validation Results for hSMG-1 inhibitor 11j
CAS No.: 1402452-15-6
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RT-PCRGel ElectrophoresisCell Imaging/Staining
  • RT-PCR
  • RT-PCR
  • Gel Electrophoresis
  • Cell Imaging/Staining
  • Gel Electrophoresis

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  • hSMG-1 inhibitor 11j Chemical Structure
    hSMG-1 inhibitor 11j Chemical Structure
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    hSMG-1 inhibitor 11j purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 1;16(1):5828. [Abstract]

    Customer Validation
     Violin plot comparing the expression changes of NMD transcripts across different groups of m6A levels in DMSO and hSMG-1 inhibitor 11j (SMG1i) (300 nM; 4 h) treated HEK293T cells.

  • 1/16

    hSMG-1 inhibitor 11j purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 1;16(1):5828. [Abstract]

    Customer Validation
     Comparing the expression changes for misprocessed isoforms with their counterpart protein-coding transcripts, respectively, in DMSO and hSMG-1 inhibitor 11j (SMG1i, 300 nM; 4 h) treated HEK293T cells. The results demonstrate that inhibiting SMG1 using the hSMG-1 inhibitor 11j (SMG1i) selectively blocks the NMD pathway.

  • 1/16

    hSMG-1 inhibitor 11j purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Jul 17;44(8):115985. [Abstract]

    Customer Validation
     Agarose gels of RT-PCR products for PEs in DHX9, RPS9, TRA2A, SRSF2, and SRSF6 in A704 cells treated with DMSO, mTORi, or hSMG-1 inhibitor 11j (SMG1i, 300 nM; 24 h), each with quantification of three biological replicates.

  • 1/16

    hSMG-1 inhibitor 11j purchased from MedChemExpress. Usage Cited in: Pharm Biol. 2025 Dec;63(1):645-662. [Abstract]

    Customer Validation
     Bright field images of human colonoids were taken after exposure to the indicated treatments, with observations made at 0 and 2 h following forskolin treatment. Colonoids were pre-treated for an hour with α,β-dehydromonacolin K (20 µM) with or without hSMG-1 inhibitor 11j (SMG1i) (1 µM) (scale bar = 500 µm). The results showed that the inhibitory effect of α,β-dehydromonacolin K on forskolin-induced fluid secretion was significantly diminished in the presence of the SMG1 inhibitor (hSMG-1 inhibitor 11j (SMG1i)).

  • 1/16

    hSMG-1 inhibitor 11j purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Aug 8;14(1):4760. [Abstract]

    Customer Validation
     Elevated transcript expression levels of two PTC-containing transcript isoforms of TP53 upon NMD inhibition by hSMG-1 inhibitor 11j (SMG1i, 300 nM, 4 h) in HCC1599 cells, as indicated by RT-PCR analysis. The 689-bpproduct corresponds to the predominant novel transcript isoform containing a retained intron, while the 170-bpproduct corresponds to a second, minor novel transcript isoform using a novel 3’ splice site. GAPDH was usedas the loading control for RT-PCR. Western blot analysis of phosphorylated UPF1 (pUPF1) was used to measureNMD activity, and β-actin was used as the loading control for Western blot. Each RT-PCR or Western blot wasrepeated twice and yielded consistent results.

  • hSMG-1 inhibitor 11j