1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Cell Cycle/DNA Damage
  2. PI3K
    mTOR
    GSK-3
    CDK
  3. hSMG-1 inhibitor 11j

hSMG-1 inhibitor 11j 

Cat. No.: HY-124719 Purity: 99.28%
Handling Instructions

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.

For research use only. We do not sell to patients.

hSMG-1 inhibitor 11j Chemical Structure

hSMG-1 inhibitor 11j Chemical Structure

CAS No. : 1402452-15-6

Size Price Stock Quantity
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].

IC50 & Target[1]

hSMG-1

0.11 nM (IC50)

mTOR

50 nM (IC50)

PI3Kγ

60 nM (IC50)

PI3Kα

92 nM (IC50)

GSKα

260 (IC50)

GSKβ

330 (IC50)

CDK2

7.1 μM (IC50)

CDK1

32 μM (IC50)

In Vitro

hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells[1].
hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC50 of 75 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

566.07

Formula

C₂₇H₂₈ClN₇O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 80 mg/mL (141.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7666 mL 8.8328 mL 17.6657 mL
5 mM 0.3533 mL 1.7666 mL 3.5331 mL
10 mM 0.1767 mL 0.8833 mL 1.7666 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6 mg/mL (10.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.28%

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hSMG-1 inhibitor 11j
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HY-124719
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