1. PI3K/Akt/mTOR
    Stem Cell/Wnt
    Cell Cycle/DNA Damage
  2. PI3K
    mTOR
    GSK-3
    CDK
  3. hSMG-1 inhibitor 11j

hSMG-1 inhibitor 11j 

Cat. No.: HY-124719 Purity: 98.91%
Handling Instructions

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.

For research use only. We do not sell to patients.

hSMG-1 inhibitor 11j Chemical Structure

hSMG-1 inhibitor 11j Chemical Structure

CAS No. : 1402452-15-6

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Description

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].

IC50 & Target[1]

hSMG-1

0.11 nM (IC50)

mTOR

50 nM (IC50)

PI3Kγ

60 nM (IC50)

PI3Kα

92 nM (IC50)

GSKα

260 (IC50)

GSKβ

330 (IC50)

CDK2

7.1 μM (IC50)

CDK1

32 μM (IC50)

In Vitro

hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells[1].
hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC50 of 75 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

566.07

Formula

C₂₇H₂₈ClN₇O₃S

CAS No.

1402452-15-6

SMILES

O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1Cl)(N(CC)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References
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Keywords:

hSMG-1 inhibitor 11jPI3KmTORGSK-3CDKPhosphoinositide 3-kinaseMammalian target of RapamycinGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinasehSMG-1PI3KαPI3KγCDK1CDK2cancerUPF1Inhibitorinhibitorinhibit

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hSMG-1 inhibitor 11j
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