Calpain
calcium-activated neutral cysteine protease
Calpain is a widely expressed cytosolic cysteine protease; its substrate recognition sequences differ from those of caspases, and it exists as two isoforms (Calpain I and Calpain II) with distinct requirements for calcium ions. It is activated by elevated intracellular calcium concentrations; consequently, it becomes activated and participates in the process of cell death in various cell types exposed to apoptotic signals. However, calpain is not a prerequisite for all apoptotic events; for instance, while it is essential for specific instances of apoptosis induction in thymocytes and hepatocytes, it is not required for Fas-induced apoptosis in Jurkat cells. Furthermore, calpain-mediated proteolytic cleavage is implicated in both necrotic and apoptotic processes associated with neurodegenerative diseases, such as cerebral ischemia and Alzheimer's disease[1].
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Calpain Related Products (2)
Related Products (2)
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CAST-calpain-2 stabilizer-1
0 ImagesCat. No.: HY-186130CAS No.: 3110929-05-7CAST-calpain-2 stabilizer-1 is a blood-brain barrier permeable stabilizer of CAST-calpain-2 interaction. CAST-calpain-2 stabilizer-1 shows no activity against GSK3. CAST-calpain-2 stabilizer-1 can be used in the research of Huntington's disease and tauopathies.
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N-Acetyl-L-leucyl-L-leucyl-L-methional
0 ImagesCat. No.: HY-103321CAS No.: 145757-50-2N-Acetyl-L-leucyl-L-leucyl-L-methional is a Calpain II inhibitor with an IC50 of 0.24 μM against porcine Calpain II. N-Acetyl-L-leucyl-L-leucyl-L-methional forms a stable tetrahedral adduct with the thiol group at the active site of Calpain II, thereby inhibiting proteolytic activity. N-Acetyl-L-leucyl-L-leucyl-L-methionally inhibits cathepsins in a non-selective manner. N-Acetyl-L-leucyl-L-leucyl-L-methional reduces SARS-CoV-2 infection levels in human coronary artery endothelial cells in vitro. N-Acetyl-L-leucyl-L-leucyl-L-methional can be used in research related to cataracts and coronavirus infections.
