2. Signaling Pathways
  3. Apoptosis
  4. Cuproptosis

Cuproptosis

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12040
    Elesclomol
    		Inducer 99.80%
    Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research.
    Elesclomol
  • HY-B0240
    Disulfiram
    		Inducer 99.92%
    Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu2+ increases intracellular ROS levels and induces cuproptosis.
    Disulfiram
  • HY-W076067
    Ammonium tetrathiomolybdate(VI)
    		Inhibitor 99.99%
    Ammonium tetrathiomolybdate(VI) is a copper chelator and also is a class of sulfide donor. Ammonium tetrathiomolybdate(VI) has neuroprotection effects. Ammonium tetrathiomolybdate(VI) can be used for the research of brain ischemia.
    Ammonium tetrathiomolybdate(VI)
  • HY-B0572
    Zinc Pyrithione
    		Inducer 99.49%
    Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis.
    Zinc Pyrithione
  • HY-B0300
    Penicillamine
    		Inhibitor ≥98.0%
    Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria.
    Penicillamine
  • HY-156376
    Cu(II)-Elesclomol
    		Inducer 99.99%
    Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity.
    Cu(II)-Elesclomol
  • HY-156780
    NSC 689534
    		Inhibitor
    NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has antitumor activity.
    NSC 689534
  • HY-163200
    Cu(I) chelator 1
    		Inhibitor
    Cu(I) chelator 1 (Compound LH2) is a chelator which targets the Cu(I) redox state. Cu(I) chelator 1 prevents ROS production.
    Cu(I) chelator 1
  • HY-16739
    Emeramide
    		Inhibitor 99.56%
    Emeramide is a thiol-redox antioxidant and heavy metal chelator.
    Emeramide
  • HY-B0300S
    Penicillamine-d3
    		Inhibitor
    Penicillamine-d3 is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
    Penicillamine-d<sub>3</sub>
  • HY-128530
    Tetrathiomolybdate
    		Inhibitor
    Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma.
    Tetrathiomolybdate
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