Cathepsin S
Cathepsin S (CTSS) occupies a distinctive niche in immunity because, unlike most lysosomal cathepsins, it retains proteolytic activity at neutral pH, allowing it to function outside the acidic lysosome. Its defining role is the degradation of the MHC class II-associated invariant chain in antigen-presenting cells such as dendritic cells, macrophages, and B cells, thereby controlling peptide loading and T cell activation. Expression is largely restricted to cells of the immune system, and levels increase during inflammation. This biology has made CTSS an actively pursued drug target, with inhibitors investigated for autoimmune, cardiovascular, and chronic pain indications; cystatin C serves as an important physiological inhibitor of the enzyme.
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Cathepsin S Recombinant Proteins (2)
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Inhibitors & Agonists (20)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
