KIR2DL5
KIR2DL5 is an inhibitory killer-cell immunoglobulin-like receptor that is unusual in being present in both centromeric (KIR2DL5A) and telomeric (KIR2DL5B) forms within the KIR gene complex, with highly similar proteins encoded by the two genes. KIR2DL5 is a two-domain receptor whose cytoplasmic tail contains two ITIM motifs mediating SHP-1/SHP-2 recruitment and inhibitory signaling in NK cells and some T cells. Unlike well-characterized KIRs, its HLA class I ligand remains uncertain: KIR2DL5 has been reported to recognize HLA-G in some studies, while other evidence suggests binding to certain HLA-C alleles or non-classical ligands, and it can additionally function through homophilic KIR2DL5-KIR2DL5 interactions on opposing cells. KIR2DL5 expression, like other KIRs, is variegated and stochastically acquired during NK-cell maturation. The gene is associated with autoimmune and inflammatory phenotypes: KIR2DL5 has been linked to psoriatic arthritis susceptibility in combination with HLA-Cw alleles, and influences outcome in allogeneic stem-cell transplantation and reproduction, where maternal KIR2DL5 expression on uterine NK cells may affect placentation.
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KIR2DL5 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
