2. Recombinant Proteins
  3. Receptor Proteins Biotinylated Proteins
  4. Killer-Cell Immunoglobulin-like Receptors
  5. KIR2DL5
  6. KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi)

KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P77730
Handling Instructions

KIR2DL5/CD158f, present on NK cells, acts as a receptor for HLA-C alleles. Its inhibitory function finely tunes NK cell activity, preventing cell lysis by interacting with specific HLA-C molecules. This dynamic engagement contributes to the nuanced balance of inhibitory signals in the immune system, regulating NK cell responses to potential targets. KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived KIR2DL5/CD158f protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi) is 219 a.a., with molecular weight of 45-52 kDa.

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Description

KIR2DL5/CD158f, present on NK cells, acts as a receptor for HLA-C alleles. Its inhibitory function finely tunes NK cell activity, preventing cell lysis by interacting with specific HLA-C molecules. This dynamic engagement contributes to the nuanced balance of inhibitory signals in the immune system, regulating NK cell responses to potential targets. KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived KIR2DL5/CD158f protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi) is 219 a.a., with molecular weight of 45-52 kDa.
Background

KIR2DL5/CD158f, expressed on natural killer (NK) cells, functions as a receptor for HLA-C alleles. This receptor operates in an inhibitory manner, regulating NK cell activity to prevent cell lysis. By interacting with specific HLA-C molecules, KIR2DL5 contributes to the delicate balance of inhibitory signals in the immune system, fine-tuning the response of NK cells to potential targets.
Species

Human
Source

HEK293
Tag

C-Avi;C-His
Accession

Q8N109 (H22-H240)
Gene ID

57292  [NCBI]
Molecular Construction
N-term
CD158f (H22-H240)
Accession # Q8N109
His-Avi
C-term
Synonyms
KIR2DL5A; CD158F; CD158F1; KIR2DL5; KIR2DL5.1; KIR2DL5.3; KIR2DL5A; KIR2DL5B
Molecular Weight

45-52 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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KIR2DL5/CD158f Protein, Human (Biotinylated, HEK293, His-Avi)
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