Sialyltransferase
Sialyltransferase
Sialyltransferases are enzymes that transfer sialic acid to nascent oligosaccharides. Sialyltransferases (SiaTs) exhibit distinct characteristics and preferences, such as for substrates and glycosidic linkages. Sialyltransferases use cytidine monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) as an activated sugar donor. Overexpression of sialyltransferases is associated with tumor hypersialylation and poor outcome[1].
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Sialyltransferase Related Products (15)
Related Products (15)
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3FAx-Neu5Ac
0 Images3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X.
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Lith-O-Asp
0 ImagesLith-O-Asp is a sialytransferase (ST) inhibitor, with IC50s of 12-37 μM.
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CMP-sialic acid synthetase (NmCSS)
0 ImagesCMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases.
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α2,3-Sialyltransferase, Pasteurella multocida (P-1059)
0 ImagesCat. No.: HY-E70056CAS No.: 71124-51-1Synonyms: PmST1(M144D)α2,3-Sialyltransferase, Pasteurella multocida (P-1059) (PmST1(M144D)), a sialyltransferase, can be isolated from Pasteurella multocida. alpha-2,3-Sialyltransferase (PmST1) can be converted into regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening.
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ST6GAL1-IN-1
0 ImagesST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor (IC50 = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin/VEGFR2-mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC).
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(R)-Lith-O-Asp
0 ImagesSynonyms: α-2,3-Sialyltransferase-IN-1(R)-Lith-O-Asp (α-2,3-Sialyltransferase-IN-1) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM.
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N-Biotinyl-6-aminohexanoic acid
0 ImagesSynonyms: N-(+)-Biotinyl-6-aminohexanoic acidN-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) can be used to perform biotinylation.
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CMP-SiaNAz sodium
0 ImagesCat. No.: HY-112944ASynonyms: CMP-NeuNAz sodium; CMP-Neu5Az sodiumCMP-SiaNAz (CMP-NeuNAz) sodium is a sialic acid nucleotide sugar derivative. CMP-SiaNAz sodium is integrated into the glycosidic chain through the action of STs in the Golgi apparatus, forming SiaNAz substances. CMP-SiaNAz sodium can serve as a substrate for bacterial-derived sialic acid transferases and is used for chemical enzymatic labeling and imaging of cell surface glycosides.
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alpha-2,3-Sialyltransferase (PmST2)
0 ImagesCat. No.: HY-E70065CAS No.: 71124-51-1alpha-2,3-Sialyltransferase (PmST2) is a sialyltransferase produced by Pasteurella multocida (Pm) and plays an important role in the pathogenesis of Pm. alpha-2,3-Sialyltransferase (PmST2) can be used to synthesize sialyllactosyl sphingosine (lyso-GM3).
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SPP-002
0 ImagesSPP-002 is a ST6GAL1 inhibitor with a human IC50 of 16.7 μM. SPP-002 selectively inhibits N-glycan sialylation over O-glycan sialylation and binds strongly to the enzyme active site. SPP-002 suppresses expression of signaling proteins in the integrin/FAK/paxillin pathway. SPP-002 can be used for the research of triple negative breast cancer metastasis.
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SPP-037
0 ImagesCat. No.: HY-172888SPP-037 is an orally active and selective inhibitor of ST6GAL1 (IC50 = 3.59 μM). SPP-037 inhibits integrin α2,6-sialylation and integrin-FAK-paxillin pathway. SPP-037 inhibits cancer cell proliferation, migration and exhibits antiangiogenic activity. SPP-037 has anti-tumor activity in MDA-MB-231 xenograft mouse model. SPP-037 can be used for the research of triple-negative breast cancer.
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ST6 Sialyltransferase 1
0 ImagesCat. No.: HY-E70150Synonyms: EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer.
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EBU-141
0 ImagesCat. No.: HY-P991369EBU-141 is a human monoclonal antibody (mAb) targeting CD75/ST6GAL1. EBU-141 can be used in B-cell lymphoma and multiple myeloma research.
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