1. Screening Libraries
  2. Mitochondria-Targeted Compound Library

Mitochondria-Targeted Compound Library

Cat. No.: HY-L089
Library Contents: XLSX PDF SDF

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 370 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

MCE Mitochondria-Targeted Compound Library can be supplied as pre-dissolved Solutions or Solid. For pre-dissolved solutions in this library, there are 365 compounds supplied in 10 mM solution and 5 compounds supplied in 2 mM solution.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, and 2 mM for compounds with solubility between 2 mM and 10 mM.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock

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Description
& Advantages

•   A unique collection of 370 mitochondria-targeted compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc.

•   A useful tool for drug discovery of mitochondria-related diseases.

•   Bioactivity and safety confirmed by preclinical research and /or clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   High purity and quality validated by NMR and LC/MS.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 370 Mitochondria-Targeted compounds supplied as pre-dissolved Solutions or Solid.
Solution: 365 compounds supplied in 10 mM solution, 5 compounds supplied in 2 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.
Storage:
-80°C
Shipping:
Blue ice
Composition

Mitochondria-Targeted Compound Library

Source: MedChem Express

Documentation

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    Product Name:
    Mitochondria-Targeted Compound Library
    Cat. No.:
    HY-L089
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack