Signaling Pathway

BCRP

BCRP

Related Products

PDF File 0.22MB

BCRP Inhibitors & Modulators (6)

Product Name Catalog No. Brief Description
Elacridar

HY-50879

Elacridar (GF120918; GW0918) is a  P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.

Ko 143

HY-10010

Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters.

KS176

HY-19753

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively).

YHO-13177

HY-12757

YHO-13177 is a potent and specific inhibitor of BCRP;  potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.

YHO-13351

HY-12758

YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.

YHO-13351 free base

HY-12758A

YHO-13351 (free base) is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.