1. NF-κB
  2. NF-κB

NF-κB

NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB Isoform Specific Products:

  • NF-κB

  • NF-κB1/p50

  • RelA/p65

  • RelB

NF-κB Related Products (64):

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor 99.64%
    BAY 11-7082 is a NF-κB inhibitor. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with an IC50 of 0.19 μM and 0.96 μM, respectively.
  • HY-A0190
    Ceruletide Activator 99.96%
    Ceruletide, a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, is a potent cholecystokinetic agent; also activates NF-kappaB/Rel in vitro.
  • HY-18738
    Pyrrolidinedithiocarbamate ammonium Inhibitor 99.61%
    Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor.
  • HY-P0151
    SN50 Inhibitor
    SN50 is a cell permeable inhibitor of NF-κB.
  • HY-13982
    JSH-23 Inhibitor 99.10%
    JSH-23 is an inhibitor of NF-κB with an IC50 value of 7.1 μM.
  • HY-N0274
    Caffeic acid phenethyl ester Inhibitor 99.67%
    Caffeic acid phenethyl ester is a NF-κB inhibitor.
  • HY-18935A
    CBL0137 hydrochloride Inhibitor 98.25%
    CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 µM, respectively.
  • HY-15122A
    Sinomenine hydrochloride Inhibitor >98.0%
    Sinomenine hydrochloride is a blocker of the NF-κB activation and also an activator of μ-opioid receptor.
  • HY-14645
    (-)-DHMEQ Inhibitor 98.05%
    (–)-DHMEQ is a potent NF-κB inhibitor.
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin is an inhibitor of TMEM16A chloride channel with an IC50 of 6.5 μM. Shikonin is also a specific inhibitor of PKM2 and can also inhibit tumor necrosis factor-α (TNF-α) and prevent activation of nuclear factor-κB (NF-κB) pathway.
  • HY-10257
    BAY 11-7085 Inhibitor 98.84%
    BAY 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM.
  • HY-N0176
    Dihydroartemisinin Inhibitor >99.0%
    Dihydroartemisinin inhibits NF-κB activity by blocking RelA/p65 translocation to the nucleus. Dihydroartemisinin activates autophagy induction in tumor cells.
  • HY-13812
    QNZ Inhibitor 99.00%
    QNZ shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. EVP4593 is a neuroprotective inhibitor of SOC channel.
  • HY-N0141
    Parthenolide Inhibitor 99.13%
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.
  • HY-N0197
    Baicalin Inhibitor 98.01%
    Baicalin is a flavonoid glycoside isolated from Scutellaria baicalensis. Baicalin reduces the expression of NF-κB.
  • HY-13010
    Laquinimod Inhibitor 99.84%
    Laquinimod is a potent immunomodulator; reduces NF-κB activation in astrocytic.
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
  • HY-14655
    Sulfasalazine Inhibitor >98.0%
    Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-N0191
    Andrographolide Inhibitor
    Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation.
Isoform Specific Products

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