1. NF-κB
  2. NF-κB


NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB Related Products (74):

Cat. No. Product Name Effect Purity
  • HY-13453
    BAY 11-7082 Inhibitor 99.64%
    BAY 11-7082 is a NF-κB inhibitor. BAY 11-7082 inhibits ubiquitin-specific protease (USP)7 and 21 with an IC50 of 0.19 μM and 0.96 μM, respectively.
  • HY-18738
    Pyrrolidinedithiocarbamate ammonium Inhibitor 99.61%
    Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor.
  • HY-13982
    JSH-23 Inhibitor 99.10%
    JSH-23 is an inhibitor of NF-κB with an IC50 value of 7.1 μM.
  • HY-14645
    (-)-DHMEQ Inhibitor 98.05%
    (-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin is an inhibitor of TMEM16A chloride channel with an IC50 of 6.5 μM. Shikonin is also a specific inhibitor of PKM2 and can also inhibit tumor necrosis factor-α (TNF-α) and prevent activation of nuclear factor-κB (NF-κB) pathway.
  • HY-A0203
    Pentosan Polysulfate >98.0%
    Pentosan polysulfate is a potent and selective HIV inhibitor.
  • HY-N0274
    Caffeic acid phenethyl ester Inhibitor 99.67%
    Caffeic acid phenethyl ester is a NF-κB inhibitor.
  • HY-N0170
    Indole-3-carbinol Inhibitor >98.0%
    Indole-3-carbinol suppresses NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist.
  • HY-P0151
    SN50 Inhibitor
    SN50 is a cell permeable inhibitor of NF-κB.
  • HY-N0176
    Dihydroartemisinin Inhibitor >99.0%
    Dihydroartemisinin inhibits NF-κB activity by blocking RelA/p65 translocation to the nucleus. Dihydroartemisinin activates autophagy induction in tumor cells.
  • HY-10257
    BAY 11-7085 Inhibitor 98.84%
    BAY 11-7085 is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM.
  • HY-N0141
    Parthenolide Inhibitor 99.13%
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.
  • HY-13812
    QNZ Inhibitor 99.00%
    QNZ shows strong inhibitory effects on NF-κB transcriptional activation andTNF-α production with IC50s of 11 and 7 nM, respectively. EVP4593 is a neuroprotective inhibitor of SOC channel.
  • HY-13010
    Laquinimod Inhibitor 99.96%
    Laquinimod is a potent immunomodulator; reduces NF-κB activation in astrocytic.
  • HY-N0904
    Ginsenoside C-K Inhibitor 98.06%
    Ginsenoside C-K(Ginsenoside compound K) is an intestinal microbiota metabolite of ginsenoside Rb1; possessing anti-proliferative and anti-inflammatory activities.
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits levels, NF-κB activity, and COX-2 expression.
  • HY-N0197
    Baicalin Inhibitor 98.01%
    Baicalin, one the effective compositions of scutellaria baicalensis, possesses multiple properities such as antioxidant, anti-tumor, anti-HIV, treating cardiovascular disease and so on.
  • HY-N2149
    Tomatidine Inhibitor >98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
  • HY-14655
    Sulfasalazine Inhibitor >98.0%
    Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.
  • HY-N0191
    Andrographolide Inhibitor
    Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation.