Signaling Pathway

NF-κB

NF-κB

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NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. There are five proteins in the mammalian NF-κB family: NF-κB1, NF-κB2, RelA, RelB, c-Rel.

NF-κB Inhibitors & Modulators (39)

Product Name Catalog No. Brief Description
(+)-DHMEQ

HY-14645A

The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-κB.

(-)-DHMEQ

HY-14645

(-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).

1-O-Acetylbritannilactone

HY-N0896

1-O-Acetylbritannilactone(Inulicin) is a sesquiterpene isolated from the medicinal plant Inula britannica; anticancer and anti-inflammation acitvity.

Adjudin

HY-18996

Adjudin is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.

Andrographolide

HY-N0191

Andrographolide(Andrographis) is an irreversible antagonist of NF-κB and prevents in vitro T cell activation; displays antiviral, antiinflammatory, antiapoptotic, and antihyperglycemic properties.

BAY 11-7082

HY-13453

BAY 11-7082 is an irreversible inhibitor of IKKα and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC50=10 μM).

Berbamine dihydrochloride

HY-N0714A

Berbamine dihydrochloride, a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several cancers.

CID-2858522

HY-15530

CID-2858522 selectively inhibits the NF-κB pathway  (IC50 < 0.1 μM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.

Cucurbitacin E

HY-N0417

Cucurbitacin E is a widely available plant-derived natural product, making it a useful tool to study actin dynamics in cells and actin-based processes such as cytokinesis.

DHMEQ racemate

HY-14645B

DHMEQ racemate is the racemate of DHMEQ.

Didox

HY-19387

Didox is a strong inhibitor of ribonucleotide reductase (RR) that interferes with DNA synthesis and repair by blocking the production of deoxyribonucleotides and has demonstrated antitumor effects for decades.

Erdosteine

HY-B0289

Erdosteine is a mucolytic which is used in treatment of excessive viscous mucus.

Evodiamine

HY-N0114

Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.

Ginsenoside F1

HY-N0598

Ginsenoside F1, a  metabolite of ginsenoside Rg1, is reported to be antiaging and antioxidative, and to have beneficial effects on skin.

Ginsenoside Rb1

HY-N0039

Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.

Ginsenoside Rb2

HY-N0040

Ginsenoside Rb2 is a 20(S)-protopanaxadiol glycoside extracted from ginseng, shows potent antioxidant and anticancer biological activities.

Ginsenoside Rb3

HY-N0041

Ginsenoside Rb3 is a natural triterpenoid saponin; has various pharmacological effects.

Ginsenoside Rc

HY-N0042

Ginsenoside Rc is a steroid glycoside, and triterpene saponins, found exclusively in the plant genus Panax (ginseng); have properties that inhibit or prevent tumors growth.

Ginsenoside Rd

HY-N0043

Ginsenoside Rd is a protopanaxadiol which has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions.

Ginsenoside Re

HY-N0044

Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.