1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC1 Inhibitors

HDAC1 Inhibitors

HDAC

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

HD1

HD2

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Sorry. There is currently no product that acts on isoform HDAC1 together.

Please try each isoform separately.

HDAC1 Specific Inhibitors
Product Name HDAC1 HDAC HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2 HDAC1 Selectivity Purity
IDO1 and HDAC1 Inhibitor
HDAC1, IC50: 66.5 nM
                          Selective Inhibitor
SS-208
HDAC1, IC50: 1.39 μM
       
HDAC5, IC50: 6.91 μM
HDAC6, IC50: 12 nM
HDAC7, IC50: 8.34 μM
HDAC8, IC50: 1.23 μM
   
HDAC11, IC50: 5.12 μM
    Selective Inhibitor
CM-675
HDAC1, IC50: 673 nM (30 min (time-dependent))
                          Selective Inhibitor
BRD-6929
HDAC1, IC50: 1 nM
 
HDAC2, IC50: 8 nM
                      Selective Inhibitor
Entinostat
HDAC1, IC50: 243 nM
 
HDAC2, IC50: 453 nM
HDAC3, IC50: 248 nM
                    Pan Inhibitor 99.65%
SW-100
HDAC1, IC50: 5.23 μM
 
HDAC2, IC50: 32.8 μM
HDAC3, IC50: 29.5 μM
HDAC4, IC50: 10.9 μM
HDAC5, IC50: 4.07 μM
HDAC6, IC50: 2.3 nM
HDAC7, IC50: 4.55 μM
HDAC8, IC50: 3.72 μM
HDAC9, IC50: 3.46 μM
HDAC10, IC50: 26.2 μM
HDAC11, IC50: 5.72 μM
    Pan Inhibitor 99.92%
Romidepsin
HDAC1, IC50: 36 nM
 
HDAC2, IC50: 47 nM
 
HDAC4, IC50: 510 nM
 
HDAC6, IC50: 14000 nM
              Pan Inhibitor 99.98%
Ricolinostat
HDAC1, IC50: 58 nM
 
HDAC2, IC50: 48 nM
HDAC3, IC50: 51 nM
HDAC4, IC50: 7000 nM
HDAC5, IC50: 5000 nM
HDAC6, IC50: 4.7 nM
HDAC7, IC50: 1400 nM
HDAC8, IC50: 100 nM
          Pan Inhibitor 99.87%
Mocetinostat
HDAC1, IC50: 0.15 μM
 
HDAC2, IC50: 0.29 μM
HDAC3, IC50: 1.66 μM
             
HDAC11, IC50: 0.59 μM
    Pan Inhibitor 99.81%
Fimepinostat
HDAC1, IC50: 1.7 nM
 
HDAC2, IC50: 5 nM
HDAC3, IC50: 1.8 nM
HDAC4, IC50: 409 nM
HDAC5, IC50: 674 nM
HDAC6, IC50: 27 nM
HDAC7, IC50: 426 nM
HDAC8, IC50: 191 nM
HDAC9, IC50: 554 nM
HDAC10, IC50: 2.8 nM
HDAC11, IC50: 5.4 nM
    Pan Inhibitor 99.95%
Tubacin
HDAC1, IC50: 1.40 μM
 
HDAC2, IC50: 6.27 μM
HDAC3, IC50: 1.27 μM
HDAC4, IC50: 17.30 μM
HDAC5, IC50: 3.35 μM
HDAC6, IC50: 4 nM
HDAC7, IC50: 9.70 μM
HDAC8, IC50: 1.27 μM
HDAC9, IC50: 4.31 μM
HDAC10, IC50: 3.71 μM
HDAC11, IC50: 3.79 μM
    Pan Inhibitor 98.87%
Tubastatin A
HDAC1, IC50: 16400 nM
         
HDAC6, IC50: 15 nM
 
HDAC8, IC50: 854 nM
          Pan Inhibitor >98.0%
Tacedinaline
HD1, IC50: 0.9 μM
 
HD2, IC50: 0.9 μM
HD3, IC50: 1.2 μM
                    Pan Inhibitor 99.51%
ACY-738
HDAC1, IC50: 94 nM
 
HDAC2, IC50: 128 nM
HDAC3, IC50: 218 nM
   
HDAC6, IC50: 1.7 nM
              Pan Inhibitor 99.94%
Dacinostat
HDAC1, IC50: 9 nM
HDAC, IC50: 32 nM
                        Pan Inhibitor >98.0%
RG2833
HDAC1, IC50: 60 nM
   
HDAC3, IC50: 50 nM
                    Pan Inhibitor 99.31%
Tubastatin A Hydrochloride
HDAC1, IC50: 16400 nM
         
HDAC6, IC50: 15 nM
 
HDAC8, IC50: 854 nM
          Pan Inhibitor 98.31%
Pracinostat
HDAC1, IC50: 49 nM
 
HDAC2, IC50: 96 nM
HDAC3, IC50: 43 nM
HDAC4, IC50: 56 nM
HDAC5, IC50: 47 nM
HDAC6, IC50: 1008 nM
HDAC7, IC50: 137 nM
HDAC8, IC50: 140 nM
HDAC9, IC50: 70 nM
HDAC10, IC50: 40 nM
HDAC11, IC50: 93 nM
    Pan Inhibitor 99.07%
ACY-775
HDAC1, IC50: 2123 nM
 
HDAC2, IC50: 2570 nM
HDAC3, IC50: 11223 nM
   
HDAC6, IC50: 7.5 nM
              Pan Inhibitor 99.54%
Nexturastat A
HDAC1, IC50: 3.02 μM
 
HDAC2, IC50: 6.92 μM
HDAC3, IC50: 6.68 μM
HDAC4, IC50: 9.39 μM
HDAC5, IC50: 11.7 μM
HDAC6, IC50: 5.02 nM
HDAC7, IC50: 4.46 μM
HDAC8, IC50: 0.954 μM
HDAC9, IC50: 6.72 μM
HDAC10, IC50: 7.57 μM
HDAC11, IC50: 5.14 μM
    Pan Inhibitor 97.92%
Abexinostat
HDAC1, Ki: 7 nM
 
HDAC2, Ki: 19 nM
HDAC3/SMRT, Ki: 8.2 nM
   
HDAC6, Ki: 17 nM
 
HDAC8, Ki: 280 nM
 
HDAC10, Ki: 24 nM
      Pan Inhibitor 98.61%
CAY10603
HDAC1, IC50: 271 nM
 
HDAC2, IC50: 252 nM
HDAC3, IC50: 0.42 nM
   
HDAC6, IC50: 0.002 nM
 
HDAC8, IC50: 6851 nM
 
HDAC10, IC50: 90.7 nM
      Pan Inhibitor 95.39%
Citarinostat
HDAC1, IC50: 35 nM
 
HDAC2, IC50: 45 nM
HDAC3, IC50: 46 nM
   
HDAC6, IC50: 2.6 nM
HDAC7, IC50: 7300 nM
HDAC8, IC50: 137 nM
          Pan Inhibitor 99.02%
CUDC-101
HDAC1, IC50: 4.5 nM
HDAC, IC50: 4.4 nM
HDAC2, IC50: 12.6 nM
HDAC3, IC50: 9.1 nM
HDAC4, IC50: 13.2 nM
HDAC5, IC50: 11.4 nM
HDAC6, IC50: 5.1 nM
HDAC7, IC50: 373 nM
HDAC8, IC50: 79.8 nM
HDAC9, IC50: 67.2 nM
HDAC10, IC50: 26.1 nM
      Pan Inhibitor 99.02%
Givinostat hydrochloride monohydrate
hHDAC1, IC50: 198 nM
 
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor >98.0%
EDO-S101
HDAC1, IC50: 9 nM
 
HDAC2, IC50: 9 nM
HDAC3, IC50: 25 nM
   
HDAC6, IC50: 6 nM
 
HDAC8, IC50: 107 nM
 
HDAC10, IC50: 72 nM
      Pan Inhibitor 98.09%
Domatinostat tosylate
HDAC-1, IC50: 1.2 μM
 
HDAC-2, IC50: 1.12 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-10, IC50: 21 μM
HDAC-11, IC50: 9.7 μM
    Pan Inhibitor 98.81%
ACY-957
HDAC1, IC50: 7 nM
 
HDAC2, IC50: 18 nM
HDAC3, IC50: 1300 nM
                    Pan Inhibitor 99.91%
HPOB
HDAC1, IC50: 2.9 μM
 
HDAC2, IC50: 4.4 μM
HDAC3/NCOR2, IC50: 1.7 μM
   
HDAC6, IC50: 0.056 μM
 
HDAC8, IC50: 2.8 μM
 
HDAC10, IC50: 3.0 μM
      Pan Inhibitor >95.0%
Domatinostat
HDAC-1, IC50: 1.2 μM
 
HDAC-2, IC50: 1.12 μM
HDAC-3, IC50: 0.57 μM
 
HDAC-5, IC50: 11.3 μM
     
HDAC-9, IC50: 50 μM
HDAC-10, IC50: 21 μM
HDAC-11, IC50: 9.7 μM
    Pan Inhibitor 98.99%
CXD101
HDAC1, IC50: 63 nM
 
HDAC2, IC50: 570 nM
HDAC3, IC50: 550 nM
                    Pan Inhibitor 99.14%
SR-4370
HDAC1, IC50: 130 nM
 
HDAC2, IC50: 580 nM
HDAC3, IC50: 6 nM
   
HDAC6, IC50: 3400 nM
 
HDAC8, IC50: 2300 nM
          Pan Inhibitor 98.33%
BG45
HDAC1, IC50: 2.0 μM
 
HDAC2, IC50: 2.2 μM
HDAC3, IC50: 0.289 μM
                    Pan Inhibitor 99.71%
Givinostat
hHDAC1, IC50: 198 nM
 
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
Pimelic Diphenylamide 106
HDAC1, IC50: 150 nM
 
HDAC2, IC50: 760 nM
HDAC3, IC50: 370 nM
       
HDAC8, IC50: 5000 nM
          Pan Inhibitor >98.0%
Resminostat
HDAC1, IC50: 42.5 nM
   
HDAC3, IC50: 50.1 nM
   
HDAC6, IC50: 71.8 nM
 
HDAC8, IC50: 877 nM
          Pan Inhibitor
UF010
HDAC1, IC50: 0.5 μM
 
HDAC2, IC50: 0.1 μM
HDAC3, IC50: 0.06 μM
   
HDAC6, IC50: 9.1 μM
 
HDAC8, IC50: 1.5 μM
 
HDAC10, IC50: 15.3 μM
HDAC11, IC50: 44.5 μM
    Pan Inhibitor 99.36%
MPT0E028
HDAC1, IC50: 53.0 nM
 
HDAC2, IC50: 106.2 nM
     
HDAC6, IC50: 29.5 nM
 
HDAC8, IC50: 2532.6 nM
          Pan Inhibitor
CHDI-390576
HDAC1, IC50: 39.7 μM
   
HDAC3, IC50: 25.8 μM
HDAC4, IC50: 54 nM
HDAC5, IC50: 60 nM
hHDAC6, IC50: 6.2 μM
HDAC7, IC50: 31 nM
HDAC8, IC50: 9.1 μM
hHDAC9, IC50: 50 nM
        Pan Inhibitor
PI3K/HDAC-IN-1
HDAC1, IC50: 1.4 nM
 
HDAC2, IC50: 3.0 nM
     
HDAC6, IC50: 6.6 nM
 
HDAC8, IC50: 18 nM
          Pan Inhibitor
HDACs/mTOR Inhibitor 1
HDAC1, IC50: 0.19 nM
         
HDAC6, IC50: 1.8 nM
              Pan Inhibitor 99.12%
Givinostat hydrochloride
hHDAC1, IC50: 198 nM
 
hHDAC2, IC50: 325 nM
hHDAC3, IC50: 157 nM
hHDAC4, IC50: 1059 nM
hHDAC5, IC50: 532 nM
hHDAC6, IC50: 315 nM
hHDAC7, IC50: 524 nM
hHDAC8, IC50: 854 nM
hHDAC9, IC50: 541 nM
hHDAC10, IC50: 340 nM
hHDAC11, IC50: 292 nM
HD1-B, IC50: 7.5 nM
HD1-A, IC50: 16 nM
HD2, IC50: 10 nM
Pan Inhibitor
CRA-026440
HDAC1, Ki: 4 nM
 
HDAC2, Ki: 14 nM
HDAC3, Ki: 11 nM
   
HDAC6, Ki: 15 nM
 
HDAC8, Ki: 7 nM
 
HDAC10, Ki: 20 nM
      Pan Inhibitor