1. Signaling Pathways
  2. GPCR/G Protein
  3. Adenylate Cyclase

Adenylate Cyclase

cAMP is produced by adenylatecyclase (AC), a 12-transmembrane-spanning enzyme that catalyzes the conversion of ATP to 3′,5′-cAMP and pyrophosphate.

In neuronal and neuroendocrine cells, a variety of ligands, such as neurotransmitters and hormones, signal via activation of G protein coupled receptors (GPCRs) coupled to GSα. These receptors activate adenylatecyclases (ACs), the family of enzymes that generate cAMP.

cAMP is synthesized by adenylatecyclases (ACs) and degraded by phosphodiesterases (PDEs). Local cAMP signaling is achieved by targeting of signaling components to subcellular compartments and assembly of signaling complexes. Primary cilia also host several cAMP-signaling components: the somatostatin 3 receptor (SSTR3), various adenylatecyclases (AC3, AC4, AC6, AC8), PKA, and Epac2 (exchange protein directly activated by cAMP).

Adenylate Cyclase Related Products (9):

Cat. No. Product Name Effect Purity
  • HY-15371
    Forskolin Activator 98.52%
    Forskolin is a potent adenylate cyclase activator, with IC50 and EC50 of 41 nM and 0.5 μM for type I adenylyl cyclase, respectively.
  • HY-100396
    SQ22536 Inhibitor 98.43%
    SQ22536 is an effective adenylate cyclase (AC) inhibitor.
  • HY-P0252
    α-Melanocyte-Stimulating Hormone (MSH), amide Activator 98.55%
    α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
  • HY-101279
    ST034307 Inhibitor 98.11%
    ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
  • HY-101862
    CB-7921220 Inhibitor >98.0%
    CB-7921220 is an adenylate cyclase inhibitor.
  • HY-103193
    NKH477 Activator
    NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.
  • HY-P1852
    TIP 39, Tuberoinfundibular Neuropeptide Activator
    TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. TIP 39 is highly conserved among species. TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through parathyroid hormone 2 receptor (PTH2R).
  • HY-100524
    LRE1 Inhibitor
    LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.
  • HY-P1495
    Small Cardioactive Peptide B SCPB Activator
    Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
Isoform Specific Products

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