1. GPCR/G Protein
  2. Adenylate Cyclase
  3. LRE1

LRE1 

Cat. No.: HY-100524 Purity: 99.59%
Handling Instructions

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

For research use only. We do not sell to patients.

LRE1 Chemical Structure

LRE1 Chemical Structure

CAS No. : 1252362-53-0

Size Price Stock Quantity
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 430 In-stock
Estimated Time of Arrival: December 31
100 mg USD 745 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

IC50 & Target

Adenylyl cyclase[1]

In Vitro

LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism[1].

LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition[1].

LRE1 (0.5-100 μM, 60 minutes ) inhibits sperm and mitochondrial functions of sAC[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Mouse cauda sperm
Concentration: 0.5-100 µM
Incubation Time: 60 minutes
Result: LRE1 inhibits sAC dependent sperm capacitation[1].
Molecular Weight

280.78

Formula

C₁₂H₁₃ClN₄S

CAS No.

1252362-53-0

SMILES

NC1=NC(N(CC2=CC=CS2)C3CC3)=CC(Cl)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (445.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5615 mL 17.8075 mL 35.6151 mL
5 mM 0.7123 mL 3.5615 mL 7.1230 mL
10 mM 0.3562 mL 1.7808 mL 3.5615 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LRE1LRE 1LRE-1Adenylate CyclaseAdenylyl cyclaseInhibitorinhibitorinhibit

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LRE1
Cat. No.:
HY-100524
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