1. GPCR/G Protein
  2. Adenylate Cyclase

LRE1 

Cat. No.: HY-100524
Handling Instructions

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

For research use only. We do not sell to patients.

LRE1 Chemical Structure

LRE1 Chemical Structure

CAS No. : 1252362-53-0

Size Price Stock
5 mg USD 160 Get quote
10 mg USD 290 Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.

IC50 & Target

Adenylyl cyclase[1]

In Vitro

LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism[1].

LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition[1].

LRE1 (0.5-100 μM, 60 minutes ) inhibits sperm and mitochondrial functions of sAC[1].

Western Blot Analysis[1]

Cell Line: Mouse cauda sperm
Concentration: 0.5-100 µM
Incubation Time: 60 minutes
Result: LRE1 inhibits sAC dependent sperm capacitation[1].
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5615 mL 17.8075 mL 35.6151 mL
5 mM 0.7123 mL 3.5615 mL 7.1230 mL
10 mM 0.3562 mL 1.7808 mL 3.5615 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

280.78

Formula

C₁₂H₁₃ClN₄S

CAS No.

1252362-53-0

SMILES

NC1=NC(N(CC2=CC=CS2)C3CC3)=CC(Cl)=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
LRE1
Cat. No.:
HY-100524
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LRE1

Cat. No.: HY-100524