1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. Together with the acetylpolyamine amidohydrolases and the acetoin utilization proteins, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily.

HDAC Related Products (67):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A Inhibitor 99.53%
    Trichostatin A (TSA) is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM; HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
  • HY-10224
    Panobinostat Inhibitor 98.07%
    Panobinostat is a novel histone deacetylase (HDAC) inhibitor with a multi-targeted profile.
  • HY-10221
    Vorinostat Inhibitor 99.85%
    Vorinostat is an inhibitor of HDAC1/3 with IC50 values of 10 nM and 20 nM, respectively.
  • HY-12163
    Entinostat Inhibitor 98.29%
    Entinostat is the class I-selective HDAC inhibitor, with IC50 of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3.
  • HY-12164
    Mocetinostat Inhibitor 99.49%
    Mocetinostat is a potent isotype-selective HDAC inhibitor with IC50 of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively.
  • HY-18361
    TMP195 Inhibitor 99.42%
    TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM.
  • HY-100871
    WT-161 Inhibitor >98.0%
    WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM.
  • HY-101780
    EDO-S101 Inhibitor 98.09%
    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively.
  • HY-16026
    ACY-1215 Inhibitor 99.49%
    ACY-1215 is a potent and selective HDAC6 inhibitor, with an enzymatic IC50 value of 5 nM.
  • HY-10225
    Belinostat Inhibitor 99.66%
    Belinostat is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-15433
    Quisinostat Inhibitor 98.09%
    Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
  • HY-15149
    Romidepsin Inhibitor 99.93%
    Romidepsin (FK228, depsipeptide) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
  • HY-10585A
    Valproic acid sodium salt Inhibitor >98.0%
    Valproic acid sodium salt is a histone deacetylase (HDAC) inhibitor (IC50=10 uM in Hela cell, 24h) has an anticancer effect.
  • HY-B0350A
    Sodium Butyrate Inhibitor >98.00%
    Sodium Butyrate is a histone deacetylase (HDAC) inhibitor, has anti-tumor effects in several cancers.
  • HY-13515
    Sirtinol Inhibitor >98.0%
    Sirtinol is a sirtuin inhibitor; inhibit the growth of MCF-7 cells with an IC50 of 48.6 μM at 24 h.
  • HY-13909
    RGFP966 Inhibitor 99.32%
    RGFP966 is a selective HDAC3 inhibitor with an IC50 of 80 nM and no effective inhibition of any other HDAC at concentrations up to 15 μM.
  • HY-13592
    Chidamide Inhibitor
    Chidamide is a synthetic benzamide-type HDACi which mainly acts as a class I HDACi (inhibiting HDAC1, HDAC2, HDAC3 and HDAC8 with IC50 of 95, 160, 67 and 733 nM, respectively).
  • HY-18360
    TMP269 Inhibitor 98.42%
    TMP269 is a novel and selective class IIa histone deacetylase inhibitor with IC50s of 126/80/36/9 nM for HDAC 4/5/7/9, respectively; 20-400 fold selectivity over class1 HDACs.
  • HY-18998
    LMK-235 Inhibitor 99.27%
    LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR).
  • HY-13271
    Tubastatin A Hydrochloride Inhibitor
    Tubastatin A (Hydrochloride) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).