1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. Together with the acetylpolyamine amidohydrolases and the acetoin utilization proteins, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily.

HDAC Related Products (66):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A Inhibitor 99.53%
    Trichostatin A is a potent and specific inhibitor of histone deacetylase (HDAC) activity with IC50 value of 1.8 nM.
  • HY-10224
    Panobinostat Inhibitor 98.07%
    Panobinostat is a novel histone deacetylase (HDAC) inhibitor with a multi-targeted profile.
  • HY-10221
    Vorinostat Inhibitor 99.90%
    Vorinostat is an inhibitor of HDAC1/3 with IC50 values of 10 nM and 20 nM, respectively.
  • HY-12163
    Entinostat Inhibitor 98.29%
    Entinostat is the class I-selective HDAC inhibitor, with IC50 of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3.
  • HY-12164
    Mocetinostat Inhibitor 99.49%
    Mocetinostat is a potent isotype-selective HDAC inhibitor with IC50 of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively.
  • HY-18361
    TMP195 Inhibitor 99.42%
    TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM.
  • HY-19328
    ACY-775 Inhibitor 99.54%
    ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.
  • HY-13755
    Sulforaphane Inhibitor 98.90%
    Sulforaphane is an isothiocyanate present naturally in widely consumed vegetables; has shown anticancer and cardioprotective activities.
  • HY-15149
    Romidepsin Inhibitor 99.87%
    Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 values of 36 and 47 nM, respectively.
  • HY-10225
    Belinostat Inhibitor 99.66%
    Belinostat is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-15433
    Quisinostat Inhibitor 98.09%
    Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
  • HY-10585A
    Valproic acid sodium salt Inhibitor >98.0%
    Valproic acid (sodium salt) is an HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
  • HY-16026
    ACY-1215 Inhibitor 99.49%
    ACY-1215 is a potent and selective HDAC6 inhibitor, with an enzymatic IC50 value of 5 nM.
  • HY-B0350A
    Sodium Butyrate Inhibitor >98.00%
    Sodium Butyrate is a histone deacetylase (HDAC) inhibitor, has anti-tumor effects in several cancers.
  • HY-13909
    RGFP966 Inhibitor 99.32%
    RGFP966 is a selective HDAC3 inhibitor with an IC50 of 80 nM and no effective inhibition of any other HDAC at concentrations up to 15 μM.
  • HY-18998
    LMK-235 Inhibitor 99.27%
    LMK-235 is a potent HDAC inhibitor, inhibits HDAC5, HDAC4, HDAC6, HDAC1, HDAC2, HDAC11 and HDAC8, with IC50s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively, and is used in cancer research.
  • HY-50934
    CI-994 Inhibitor 99.08%
    CI-994 (Tacedinaline) is an inhibitor of the histone deacetylase (HDAC) with an IC50 of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively.
  • HY-18360
    TMP269 Inhibitor 98.42%
    TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
  • HY-10528
    Tasquinimod Modulator 99.87%
    Tasquinimod is an allosteric modulator of HDAC4 with IC50 of 0.5 μM in 3D-HUVEC sprouting assay.
  • HY-N0141
    Parthenolide Inhibitor 99.13%
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.