1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. Together with the acetylpolyamine amidohydrolases and the acetoin utilization proteins, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily.

HDAC Related Products (60):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A Inhibitor 99.53%
    Trichostatin A is a potent and specific inhibitor of histone deacetylase (HDAC) activity with IC50 value of 1.8 nM.
  • HY-10221
    Vorinostat Inhibitor 99.85%
    Vorinostat is an inhibitor of HDAC1/3 with IC50 values of 10 nM and 20 nM, respectively.
  • HY-10224
    Panobinostat Inhibitor 98.1%
    Panobinostat is a novel histone deacetylase (HDAC) inhibitor with a multi-targeted profile.
  • HY-12163
    Entinostat Inhibitor 98.68%
    Entinostat is the class I-selective HDAC inhibitor, with IC50 of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3.
  • HY-12164
    Mocetinostat Inhibitor 99.49%
    Mocetinostat is a potent isotype-selective HDAC inhibitor with IC50 of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively.
  • HY-100748
    HDAC-IN-4 Inhibitor 98.14%
    HDAC-IN-4 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2007045844 A1 20070426.
  • HY-19747
    HPOB Inhibitor
    HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.
  • HY-10225
    Belinostat Inhibitor 99.66%
    Belinostat is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-16026
    ACY-1215 Inhibitor 99.7%
    ACY-1215 is a potent and selective HDAC6 inhibitor, with an enzymatic IC50 value of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50 of 58, 48, and 51 nM, respectively.
  • HY-15149
    Romidepsin Inhibitor 99.93%
    Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
  • HY-15433
    Quisinostat Inhibitor 98.09%
    Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
  • HY-10585A
    Valproic acid sodium salt Inhibitor >98.0%
    Valproic acid (sodium salt) is an HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
  • HY-13592
    Chidamide Inhibitor 98.21%
    Chidamide is a synthetic benzamide-type HDACi which mainly acts as a class I HDACi (inhibiting HDAC1, 2, 3 and 8 with IC50 of 95, 160, 67 and 733 nM, respectively).
  • HY-13909
    RGFP966 Inhibitor 99.32%
    RGFP966 is a selective HDAC3 inhibitor with an IC50 of 80 nM and no effective inhibition of any other HDAC at concentrations up to 15 μM.
  • HY-B0350A
    Sodium Butyrate Inhibitor >98.00%
    Sodium Butyrate is a histone deacetylase (HDAC) inhibitor, has anti-tumor effects in several cancers.
  • HY-N0141
    Parthenolide Inhibitor 99.13%
    Parthenolide is an NF-κB inhibitor, reduces histone deacetylase 1 (HDAC-1) and DNA methyltransferase 1 independent of NF-κB inhibition.
  • HY-10990
    PCI-24781 Inhibitor
    PCI-24781 (Abexinostat; CRA 24781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM.
  • HY-13271
    Tubastatin A Hydrochloride Inhibitor 98.18%
    Tubastatin A (Hydrochloride) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
  • HY-16425
    RG2833 Inhibitor 99.43%
    RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
  • HY-13515
    Sirtinol Inhibitor >98.0%
    Sirtinol is a sirtuin inhibitor; inhibit the growth of MCF-7 cells with an IC50 of 48.6 μM at 24 h.