1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. Together with the acetylpolyamine amidohydrolases and the acetoin utilization proteins, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily.

HDAC Related Products (60):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A Inhibitor
    Trichostatin A is a potent and specific inhibitor of histone deacetylase (HDAC) activity with IC50 value of 1.8 nM.
  • HY-10221
    Vorinostat Inhibitor
    Vorinostat is an inhibitor of HDAC1/3 with IC50 values of 10 nM and 20 nM, respectively.
  • HY-10224
    Panobinostat Inhibitor
    Panobinostat is a novel histone deacetylase (HDAC) inhibitor with a multi-targeted profile.
  • HY-12163
    Entinostat Inhibitor
    Entinostat is the class I-selective HDAC inhibitor, with IC50 of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3.
  • HY-12164
    Mocetinostat Inhibitor
    Mocetinostat is a potent isotype-selective HDAC inhibitor with IC50 of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively.
  • HY-10225
    Belinostat Inhibitor
    Belinostat is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-16026
    ACY-1215 Inhibitor
    ACY-1215 is a potent and selective HDAC6 inhibitor, with an enzymatic IC50 value of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50 of 58, 48, and 51 nM, respectively.
  • HY-15149
    Romidepsin Inhibitor
    Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.
  • HY-15433
    Quisinostat Inhibitor
    Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
  • HY-10990
    PCI-24781 Inhibitor
    PCI-24781 (Abexinostat; CRA 24781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM.
  • HY-13271
    Tubastatin A Hydrochloride Inhibitor
    Tubastatin A (Hydrochloride) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).
  • HY-16425
    RG2833 Inhibitor
    RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
  • HY-13515
    Sirtinol Inhibitor
    Sirtinol is a sirtuin inhibitor; inhibit the growth of MCF-7 cells with an IC50 of 48.6 μM at 24 h.
  • HY-15224
    PCI-34051 Inhibitor
    PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
  • HY-10528
    Tasquinimod Modulator
    Tasquinimod is an allosteric modulator of HDAC4 with IC50 of 0.5 μM in 3D-HUVEC sprouting assay.
  • HY-50934
    CI-994 Inhibitor
    CI-994 (Tacedinaline) is an inhibitor of the histone deacetylase (HDAC) with an IC50 of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively.
  • HY-13322
    Pracinostat Inhibitor
    Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I.
  • HY-10223
    CUDC-101 Inhibitor
    CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively.
  • HY-13506
    M344 Inhibitor
    M344 is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.
  • HY-16012
    4SC-202 Inhibitor
    4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs.