1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

HDAC

HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. Together with the acetylpolyamine amidohydrolases and the acetoin utilization proteins, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily.

HDAC Isoform Specific Products:

  • HDAC

  • HDAC1

  • HDAC2

  • HDAC3

  • HDAC4

  • HDAC5

  • HDAC6

  • HDAC7

  • HDAC8

  • HDAC9

  • HDAC10

  • HDAC11

  • HD1

  • HD2

HDAC Related Products (70):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A Inhibitor 99.53%
    Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.
  • HY-10221
    Vorinostat Inhibitor 99.90%
    Vorinostat is a potent and orally available inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and Class IV (HDAC11), with ID50 values of 10 nM and 20 nM for HDAC1/3, respectively.
  • HY-10224
    Panobinostat Inhibitor 98.42%
    Panobinostat is an oral histone deacetylase (HDAC) inhibitor with a multi-targeted profile.
  • HY-12163
    Entinostat Inhibitor 99.65%
    Entinostat is the class I-selective HDAC inhibitor, with IC50 of 243 nM, 453 nM, and 248 nM for HDAC1, HDAC2, and HDAC3.
  • HY-15149
    Romidepsin Inhibitor 99.52%
    Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 values of 36 and 47 nM, respectively.
  • HY-111342
    HDAC8-IN-1 Inhibitor 99.59%
    HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
  • HY-104008
    ACY-957 Inhibitor
    ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
  • HY-111400
    SR-4370 Inhibitor 98.33%
    SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.
  • HY-12164
    Mocetinostat Inhibitor 99.49%
    Mocetinostat is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC50s of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1, HDAC2, HDAC3 and HDAC11, respectively; Mocetinostat shows no inhibition on HDAC4, HDAC5, HDAC6, HDAC7, or HDAC8.
  • HY-10225
    Belinostat Inhibitor 99.97%
    Belinostat is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-16026
    ACY-1215 Inhibitor 98.90%
    ACY-1215 is a potent and selective HDAC6 inhibitor, with an enzymatic IC50 value of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50 of 58, 48, and 51 nM, respectively.
  • HY-B0350A
    Sodium Butyrate Inhibitor >98.00%
    Sodium Butyrate is a histone deacetylase (HDAC) inhibitor, has anti-tumor effects in several cancers.
  • HY-15433
    Quisinostat Inhibitor 98.09%
    Quisinostat (JNJ-26481585) is an orally available, potent HDAC inhibitor with IC50 values of 0.11 nM for HDAC1.
  • HY-13909
    RGFP966 Inhibitor 98.99%
    RGFP966 is a selective HDAC3 inhibitor with an IC50 of 80 nM and no effective inhibition of any other HDAC at concentrations up to 15 μM.
  • HY-10585A
    Valproic acid sodium salt Inhibitor >98.0%
    Valproic acid sodium salt is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
  • HY-15224
    PCI-34051 Inhibitor 99.46%
    PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.
  • HY-50934
    CI-994 Inhibitor 99.08%
    CI-994 (Tacedinaline) is an inhibitor of the histone deacetylase (HDAC) with an IC50 of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively.
  • HY-13428
    Tubacin Inhibitor 98.87%
    Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1.
  • HY-10585
    Valproic acid Inhibitor 98.67%
    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
  • HY-18361
    TMP195 Inhibitor 99.42%
    TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC50 of 300 nM.
Isoform Specific Products

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