1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC Isoform

HDAC

 

HDAC Related Products (197):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A
    Inhibitor 99.91%
    Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.
  • HY-A0281
    4-Phenylbutyric acid
    Inhibitor 99.98%
    4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
  • HY-10585
    Valproic acid
    Inhibitor ≥98.0%
    Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.
  • HY-13755
    Sulforaphane
    Inhibitor 99.75%
    Sulforaphane is an orally active, highly effective inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane is more capable of inducing carcinogen-detoxifying enzyme systems in rat liver and lungs than its S-isomer. Sulforaphane increases the transcription of tumor suppressor proteins and inhibits the activity of HDACs. Through the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, as well as further induction of heme oxygenase-1 (HO-1), Sulforaphane provides cardioprotection. Sulforaphan suppresses high glucose-induced pancreatic cancer via AMPK-dependent signaling pathways. Sulforaphan exhibits both anticancer and anti-inflammatory activities.
  • HY-10224
    Panobinostat
    Inhibitor 99.48%
    Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma.
  • HY-10225
    Belinostat
    Inhibitor 99.95%
    Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-10585A
    Valproic acid sodium
    Inhibitor 98.14%
    Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.
  • HY-15654
    Sodium 4-phenylbutyrate
    Inhibitor 99.96%
    Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
  • HY-B0246
    Carbamazepine
    Inhibitor 99.93%
    Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM). Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain.
  • HY-100508
    ITSA-1
    Activator ≥98.0%
    ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation.
  • HY-10223
    CUDC-101
    Inhibitor 99.19%
    CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-111048
    Corin
    Inhibitor 98.55%
    Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
  • HY-13506
    M344
    Inhibitor 98.86%
    M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.
  • HY-13606
    Dacinostat
    Inhibitor 98.45%
    Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
  • HY-W009732
    Sinapinic acid
    Inhibitor 99.95%
    Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM, and also inhibits ACE-I activity. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells. Sinapinic acid shows antioxidant and antidiabetic activities. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats.
  • HY-16914
    MC1568
    Inhibitor
    MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.
  • HY-15489
    Scriptaid
    Inhibitor 98.59%
    Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research. Scriptaid is also a sensitizer to antivirals and has potential for epstein-barr virus (EBV)-associated lymphomas treatment.
  • HY-13755A
    (R)-Sulforaphane
    Inhibitor 99.37%
    (R)-Sulforaphane (L-Sulforaphane) is an orally active, highly effective inducer of the Keap1/Nrf2/ARE pathway. (R)-Sulforaphane is more capable of inducing carcinogen-detoxifying enzyme systems in rat liver and lungs than its S-isomer. (R)-Sulforaphane increases the transcription of tumor suppressor proteins and inhibits the activity of HDACs. Through the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, as well as further induction of heme oxygenase-1 (HO-1), (R)-Sulforaphane provides cardioprotection. (R)-Sulforaphan suppresses high glucose-induced pancreatic cancer via AMPK-dependent signaling pathways. (R)-Sulforaphan exhibits both anticancer and anti-inflammatory activities.
  • HY-13432
    Nanatinostat
    Inhibitor 99.34%
    Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM.
  • HY-102033
    Oxamflatin
    Inhibitor 98.13%
    Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Oxamflatin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.