1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. HDAC Isoform

HDAC

 

HDAC Related Products (111):

Cat. No. Product Name Effect Purity
  • HY-15144
    Trichostatin A
    Inhibitor 99.91%
    Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.
  • HY-A0281
    4-Phenylbutyric acid
    Inhibitor 99.98%
    4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
  • HY-10585
    Valproic acid
    Inhibitor ≥98.0%
    Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2.
  • HY-13755
    Sulforaphane
    Inhibitor 99.11%
    Sulforaphane is an isothiocyanate present naturally in widely consumed vegetables.
  • HY-10224
    Panobinostat
    Inhibitor 99.48%
    Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities.
  • HY-10585A
    Valproic acid sodium
    Inhibitor 98.14%
    Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2.
  • HY-15654
    Sodium 4-phenylbutyrate
    Inhibitor 99.96%
    Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
  • HY-10225
    Belinostat
    Inhibitor 99.95%
    Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
  • HY-100508
    ITSA-1
    Activator ≥98.0%
    ITSA-1 is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation.
  • HY-18998
    LMK-235
    Inhibitor 99.61%
    LMK-235 is a potent and selective HDAC4/5 inhibitor, inhibits HDAC5, HDAC4, HDAC6, HDAC1, HDAC2, HDAC11 and HDAC8, with IC50s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively, and is used in cancer research.
  • HY-10223
    CUDC-101
    Inhibitor 99.19%
    CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively.
  • HY-111048
    Corin
    Inhibitor 98.75%
    Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
  • HY-13606
    Dacinostat
    Inhibitor 98.45%
    Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
  • HY-16914
    MC1568
    Inhibitor
    MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.
  • HY-N6735
    Apicidin
    Inhibitor 99.87%
    Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity.
  • HY-W009732
    Sinapinic acid
    Inhibitor 99.77%
    Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack.
  • HY-15489
    Scriptaid
    Inhibitor 98.59%
    Scriptaid is a potent histone deacetylase (HDAC) inhibitor, used in cancer research.
  • HY-13506
    M344
    Inhibitor 98.86%
    M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.
  • HY-102033
    Oxamflatin
    Inhibitor 98.13%
    Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM.
  • HY-18947
    SKLB-23bb
    Inhibitor 99.37%
    SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively.