1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Dipeptidyl Peptidase Related Products (22):

Cat. No. Product Name Effect Purity
  • HY-13749
    Sitagliptin Inhibitor 99.95%
    Sitagliptin is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts.
  • HY-13233A
    Talabostat mesylate Inhibitor
    Talabostat mesilate(PT-100; Val-boroPro) is an orally active, specific inhibitor of dipeptidyl peptidases(IC50=1 nM for DPP4), including tumor-associated fibroblast activation protein.
  • HY-10284
    Linagliptin Inhibitor 99.62%
    Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
  • HY-10285
    Saxagliptin Inhibitor 98.03%
    Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM.
  • HY-14806
    Teneligliptin Inhibitor 99.82%
    Teneligliptin is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
  • HY-101769
    UAMC00039 dihydrochloride Inhibitor 98.44%
    UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.
  • HY-13233
    Talabostat Inhibitor
    Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.
  • HY-13749B
    Sitagliptin phosphate monohydrate Inhibitor 99.72%
    Sitagliptin phosphate monohydrate is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts IC50 & Target: IC50: 19 nM (DPP4, in Caco-2 cell extracts) In Vitro: Sitagliptin phosphate exhibits a potent inhibitory effect on DPP-4 with IC50 of 19 nM from Caco-2 cell extracts[1].
  • HY-15981
    Omarigliptin Inhibitor 99.91%
    Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 μM).
  • HY-14877
    Anagliptin Inhibitor 98.05%
    Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.
  • HY-14291
    Vildagliptin Inhibitor
    Vildagliptin (LAF-237; NVP-LAF 237) inhibits DPP-4 with IC50 of 2.3 nM.
  • HY-15408A
    Trelagliptin succinate Inhibitor 99.89%
    Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
  • HY-15408
    Trelagliptin Inhibitor 99.54%
    Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).
  • HY-A0023
    Alogliptin Benzoate Inhibitor 99.93%
    Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
  • HY-14806A
    Teneligliptin hydrobromide Inhibitor 99.99%
    Teneligliptin hydrobromide is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
  • HY-12528
    DBPR108 Inhibitor
    DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.
  • HY-A0023A
    Alogliptin Inhibitor
    Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
  • HY-101605
    Prodipine hydrochloride Inhibitor
    Prodipine, a diphenyl-phosphonate derivative.
  • HY-10287
    Gosogliptin Inhibitor
    Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV).
  • HY-10286
    Dutogliptin Inhibitor
    Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.