1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. Diprotin A

Diprotin A (Synonyms: Ile-Pro-Ile)

Cat. No.: HY-111174
Handling Instructions

Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

For research use only. We do not sell to patients.

Diprotin A Chemical Structure

Diprotin A Chemical Structure

CAS No. : 90614-48-5

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Description

Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].

IC50 & Target

IC50: DPP-IV[1]

In Vitro

Diprotin A (100 μM; 30 minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].

Western Blot Analysis[1]

Cell Line: Human endothelial cells[1]
Concentration: 100 μM
Incubation Time: 30 minutes after CXCR4-blocker or Src-inhibitor treatment
Result: Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs.
In Vivo

Diprotin A (intraperitoneal injection; 70 μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].

Animal Model: Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice[1]
Dosage: 70 μg/kg
Administration: Intraperitoneal injection; twice daily; 7 days
Result: Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
Molecular Weight

341.45

Formula

C₁₇H₃₁N₃O₄

CAS No.

90614-48-5

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Diprotin AIle-Pro-IleDipeptidyl PeptidaseDPPDiabetic retinopathynormoxiaH/R conditionendothelial cellvascular leakagehECsInhibitorinhibitorinhibit

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Diprotin A
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