HBV (Hepatitis B virus), abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.
HBV Related Products (27):
| Cat. No. |
Product Name |
Effect |
Purity |
-
- HY-100029
-
| Bay 41-4109
|
Inhibitor
|
98.92%
|
|
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-13623A
-
| Entecavir monohydrate
|
Inhibitor
|
99.95%
|
|
Entecavir monohydrate (BMS200475 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
|
-
- HY-13782
-
-
- HY-108917
-
| Morphothiadin
|
Inhibitor
|
99.59%
|
|
Morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM.
|
-
- HY-112142
-
| AB-423
|
Inhibitor
|
99.60%
|
|
AB-423 is an inhibitor of HBV capsid assembly, and potent inhibits HBV replication with EC50/EC90 of 0.08-0.27 μM/0.33-1.32 μM in cells.
|
-
- HY-117650A
-
| RG7834
|
Inhibitor
|
99.29%
|
|
RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.
|
-
- HY-114314
-
| BA-53038B
|
Inhibitor
|
|
|
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly in a distinct manner, with an EC50 value of 3.32 μM.
|
-
- HY-N6939
-
| Pseudolaric Acid B
|
Inhibitor
|
|
|
Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy.
|
-
- HY-16468
-
| Squalamine
|
Inhibitor
|
>98.0%
|
|
Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity.
|
-
- HY-13986
-
| Merimepodib
|
Inhibitor
|
98.37%
|
|
Merimepodib is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.
|
-
- HY-B0255
-
| Adefovir dipivoxil
|
Inhibitor
|
98.50%
|
|
Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.
|
-
- HY-112564
-
| JNJ-632
|
Inhibitor
|
99.36%
|
|
JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM).
|
-
- HY-101954
-
| Inarigivir
|
Inhibitor
|
99.20%
|
|
Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.
|
-
- HY-107902
-
| RIG-1 modulator 1
|
Inhibitor
|
98.81%
|
|
RIG-1 modulator 1 is an anti-viral compound which can be useful for the treatment of viral infections including influenza virus, HBV, HCV and HIV extracted from patent WO 2015172099 A1.
|
-
- HY-B0955
-
| Oxethazaine
|
Inhibitor
|
99.86%
|
|
Oxethazaine is a topical anesthetic, in preventing acid-induced esophageal pain.
|
-
- HY-13623
-
| Entecavir
|
Inhibitor
|
98.88%
|
|
Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
|
-
- HY-B0017
-
| Telbivudine
|
Inhibitor
|
99.87%
|
|
Telbivudine, a specific inhibitor of hepatitis B virus (HBV) replication, is an antiviral drug used in the treatment of hepatitis B infection.
|
-
- HY-B0766
-
-
- HY-100029A
-
| Bay 41-4109 racemate
|
Inhibitor
|
98.02%
|
|
BAY 41-4109 racemate is the racemate of BAY 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-13859
-
| Clevudine
|
Inhibitor
|
>98.0%
|
|
Clevudine is an antiviral drug for the treatment of hepatitis B.
|
