HBV (Hepatitis B virus), abbreviated HBV, is a species of the genus Orthohepadnavirus, which is likewise a part of the Hepadnaviridae family of viruses. HBV causes the disease hepatitis B. The hepatitis B virus is classified as the type species of the Orthohepadnavirus, which contains three other species: the Ground squirrel hepatitis virus, Woodchuck hepatitis virus, and theWoolly monkey hepatitis B virus. The genus is classified as part of the Hepadnaviridae family. HBV is divided into four major serotypes (adr, adw, ayr, ayw) based on antigenic epitopes present on its envelope proteins, and into eight genotypes (A–H) according to overall nucleotide sequence variation of the genome. The genotypes have a distinct geographical distribution and are used in tracing the evolution and transmission of the virus. Differences between genotypes affect the disease severity, course and likelihood of complications, and response to treatment and possibly vaccination.
HBV Related Products (42):
| Cat. No. |
Product Name |
Effect |
Purity |
-
- HY-15142
-
| Doxorubicin hydrochloride
|
Inhibitor
|
99.47%
|
|
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic for the treatment of multiple cancers. The possible mechanisms by which doxorubicin acts in the cancer cell are intercalation into DNA and disruption of topoisomerase-II-mediated DNA repair. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase.
|
-
- HY-15601
-
| Vesatolimod
|
Inhibitor
|
99.56%
|
|
Vesatolimod (GS-9620) is a potent, selective and orally active agonist of Toll-Like Receptor (TLR7) with an EC50 of 291 nM.
|
-
- HY-13623A
-
| Entecavir monohydrate
|
Inhibitor
|
99.95%
|
|
Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
|
-
- HY-N0058
-
-
- HY-100029
-
| Bay 41-4109
|
Inhibitor
|
98.92%
|
|
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM.
|
-
- HY-124614
-
| GLP-26
|
Inhibitor
|
98.13%
|
|
GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.
GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.
|
-
- HY-B1826
-
| Adefovir
|
Inhibitor
|
>98.0%
|
|
Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.
|
-
- HY-N6939
-
| Pseudolaric Acid B
|
Inhibitor
|
99.47%
|
|
Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy.
|
-
- HY-13782
-
-
- HY-N0056
-
| Isochlorogenic acid A
|
Inhibitor
|
98.71%
|
|
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with antioxidant and anti-inflammatory activities .
|
-
- HY-108917
-
| Morphothiadin
|
Inhibitor
|
99.59%
|
|
Morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM.
|
-
- HY-112142
-
| AB-423
|
Inhibitor
|
99.60%
|
|
AB-423 is an inhibitor of HBV capsid assembly, and potent inhibits HBV replication with EC50/EC90 of 0.08-0.27 μM/0.33-1.32 μM in cells.
|
-
- HY-117650A
-
| RG7834
|
Inhibitor
|
99.29%
|
|
RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells.
|
-
- HY-16468
-
| Squalamine
|
Inhibitor
|
>98.0%
|
|
Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity.
|
-
- HY-13910
-
| Tenofovir
|
Inhibitor
|
99.77%
|
|
Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV).
|
-
- HY-B0255
-
| Adefovir dipivoxil
|
Inhibitor
|
99.87%
|
|
Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.
|
-
- HY-101954
-
| Inarigivir
|
Inhibitor
|
99.20%
|
|
Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.
|
-
- HY-N0664
-
| Aucubin
|
Inhibitor
|
>98.0%
|
|
Aucubin is an iridoid glycoside with a wide range of biological activities, including anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
|
-
- HY-112564
-
| JNJ-632
|
Inhibitor
|
99.36%
|
|
JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM).
|
-
- HY-13986
-
| Merimepodib
|
Inhibitor
|
98.37%
|
|
Merimepodib is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.
|
