2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. Sirtuin HBV
  4. OSS_128167

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.

For research use only. We do not sell to patients.

CAS No. : 887686-02-4

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Customer Review

Based on 31 publication(s) in Google Scholar

Other Forms of OSS_128167:

OSS_128167 Related Antibodies

Top Publications Citing Use of Products

31 Publications Citing Use of MCE OSS_128167

Cell Migration/Invasion Assay
WB
Cell Imaging/Staining
Cell Proliferation/Viability Assay
In Vivo Efficacy Study

    OSS_128167 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 8;10(1):398.  [Abstract]

    Western blot analysis of SIRT6 and ACAT2 expression in 786-O cells treated with OSS-128167 (OSS, 100 μM, 24 h), LPE18:1 (40 μM, 24 h), or both.

    OSS_128167 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 8;10(1):398.  [Abstract]

    Lipid staining confirmed that OSS-128167 (100 μM) treatment significantly inhibited LPE18:1-induced or SIRT6 overexpression-promoted lipid accumulation.

    OSS_128167 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 8;10(1):398.  [Abstract]

    Colony formation experiments revealed that OSS-128167 (100 μM) reversed the stimulatory effects of LPE18:1 or CAPZA1 overexpression on colony formation.

    OSS_128167 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 8;10(1):398.  [Abstract]

    Tumor growth curves of nude mice that were subcutaneously injected with CAPZA1-depleted or control 786-O cells and treated with OSS-128167 (50 mg/kg) or vehicle every 7 days for 21 days.

    OSS_128167 purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Dec 14;11(1):210.  [Abstract]

    Transwell assay: the migrated macrophages in the Vehicle group and OSS_128167 (200 μM) treated group.

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    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects[1][2].

    IC50 & Target[1][2]

    SIRT6

    89 μM (IC50)

    SIRT2

    751 μM (IC50)

    SIRT1

    1578 μM (IC50)

    HBV

     

    In Vitro

    OSS_128167 (Compound 9; 100 μM; 0-24 hours; BxPC3 cells) treatment increases H3K9 acetylation. And also increases GLUT-1 expression in BxPC-3 cells[1].
    ? OSS_128167 (Compound 9) effectively blunts phorbol myristate acetate (PMA)-induced TNF-α secretion in cultured BxPC-3 cells. OSS_128167 increases glucose uptake in cells[1].
    ? OSS_128167 (100 μM; 96 hours; HepG2.2.15 and HepG2-NTCP cells) treatment significantly decreaseS HBV core DNA and 3.5-Kb RNA levels. OSS_128167 treatment also inhibits hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen (HBeAg) secretions, as well as HBsAg expression in cell lysates[2].
    ? OSS_128167 (200 μM) induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell lines[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    OSS_128167 Related Antibodies

    Western Blot Analysis[1]

    Cell Line: BxPC3 cells
    Concentration: 100 µM
    Incubation Time: 0 hours, 2 hours, 6 hours, 18 hours, 24 hours
    Result: Increased H3K9 acetylation.

    RT-PCR[2]

    Cell Line: HepG2.2.15 and HepG2-sodium taurocholate cotransporting polypeptide (NTCP) cells
    Concentration: 100 µM
    Incubation Time: 96 hours
    Result: Significantly decreased HBV core DNA and 3.5-Kb RNA levels.
    In Vivo

    OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male HBV transgenic mice (6-8-week-old)[2]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection; every 4 days; for 12 days
    Result: The level of HBV DNA and 3.5-Kb RNA were markedly suppressed in HBV transgenic mice.
    Molecular Weight

    366.32

    Formula

    C19H14N2O6
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C(C1=CC(NC(C2=CC=CO2)=O)=CC=C1)NC3=CC(C(O)=O)=C(O)C=C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (272.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7299 mL 13.6493 mL 27.2985 mL
    5 mM 0.5460 mL 2.7299 mL 5.4597 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 10 mg/mL (27.30 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
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    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 98.92%

    SDS (392 KB)

    COA (252 KB) HNMR (154 KB) RP-HPLC (259 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7299 mL 13.6493 mL 27.2985 mL 68.2463 mL
    5 mM 0.5460 mL 2.7299 mL 5.4597 mL 13.6493 mL
    10 mM 0.2730 mL 1.3649 mL 2.7299 mL 6.8246 mL
    15 mM 0.1820 mL 0.9100 mL 1.8199 mL 4.5498 mL
    20 mM 0.1365 mL 0.6825 mL 1.3649 mL 3.4123 mL
    25 mM 0.1092 mL 0.5460 mL 1.0919 mL 2.7299 mL
    30 mM 0.0910 mL 0.4550 mL 0.9100 mL 2.2749 mL
    40 mM 0.0682 mL 0.3412 mL 0.6825 mL 1.7062 mL
    50 mM 0.0546 mL 0.2730 mL 0.5460 mL 1.3649 mL
    60 mM 0.0455 mL 0.2275 mL 0.4550 mL 1.1374 mL
    80 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8531 mL
    100 mM 0.0273 mL 0.1365 mL 0.2730 mL 0.6825 mL
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    OSS_128167 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    OSS_128167887686-02-4SirtuinHBVHepatitis B virusSIRT6deacetylasediabetesimmuneanti-cancerH3K9acetylationGLUT-1TNF-αchemosensitizationantiviralPPARαInhibitorinhibitorinhibit

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