2. Recombinant Proteins
  3. Fc Receptors
  4. Fc-epsilon Receptor

Fc-epsilon Receptor

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Fc epsilon receptor (FcεR) is the Fc receptor that binding immunoglobulin E (IgE). There are two types of FcεRs, called FcεRI (or high-affinity Fc epsilon R, Kd ~1nm) and FcεRII/CD23 (or low-affinity Fc epsilon R, Kd 0.1-1μm). FceRI and FcεRII/CD23 are very different in their molecular structure. FceRI belongs to the immunoglobulin superfamily and is highly homologous in sequence and structure to the IgG Fc receptors, while FcεRII/CD23 is a member of the C-type lectin superfamily. FcεRII/CD23 receptors are expressed on B cells, a variety of innate cell types and epithelial cells. FcεRI receptors are expressed on a variety of cells in addition to mast cells and basophils.A handful of other receptors, including galectin-3, FcγRIIb, FcγRIV, have been documented to interact with IgE.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72748
    CD23/Fc epsilon RII Protein, Human (HEK293, His)

    Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; FCER2; CD23A; CLEC4J; FCE2; IGEBF

    		Human HEK293
    CD23 or Fc epsilon receptor II (Fc epsilon RII) is a low-affinity receptor for immunoglobulin E (IgE) and complements receptor 2 (CR2/CD21). CD23 is present on B cells, regulates IgE production and B cell differentiation, and aids in IgE-dependent antigen uptake. CD23/Fc epsilon RII Protein, Human (HEK293, His) is the recombinant human-derived CD23/Fc epsilon RII protein, expressed by HEK293 , with N-8*His labeled tag. The total length of CD23/Fc epsilon RII Protein, Human (HEK293, His) is 274 a.a., with molecular weight of 35-40 kDa.
  • HY-P75212
    Fc epsilon RIA/FCER1A Protein, Mouse (HEK293, Fc)

    Fc epsilon RI alpha; FCE1A; FCER1A; FcERI; FceRIa

    		Mouse HEK293
    Fc epsilon RIA/FCER1A protein is a high-affinity receptor for immunoglobulin epsilon/IgE and is critical for mediating IgE effector function. It activates and differentiates myeloid cells after binding IgE and cross-linking with antigens/allergens, causing mast cells, basophils, and eosinophils to secrete mediators and cytokines. Fc epsilon RIA/FCER1A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Fc epsilon RIA/FCER1A protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P72191
    Fc epsilon RIA/FCER1A Protein, Human (His-SUMO)

    Fc epsilon RI alpha; Fc epsilon RI alpha chain ; high affinity I; receptor for; alpha subunit; Fc fragment of IgE; high affinity I; receptor for; alpha polypeptide; Fc IgE receptor; alpha chain; Fc IgE receptor; alpha polypeptide; Fc-epsilon RI-alpha; FCE 1A; FCE1A; FCER1A; Fcer1a; FCERA_HUMAN; FceRI alpha; FcERI; high affinity IgE receptor;

    		Human E. coli
    The Fc epsilon RIA/FCER1A protein is a high-affinity receptor for IgE and critically mediates IgE effector function in myeloid cells. After binding to IgE and cross-linking with antigen, it activates signaling pathways that induce myeloid cell activation and differentiation. Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) is the recombinant human-derived Fc epsilon RIA/FCER1A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) is 180 a.a., with molecular weight of ~37 kDa.
  • HY-P74320
    CD23/Fc epsilon RII Protein, Rat (HEK293, Fc)

    Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; FCER2; CD23A

    		Rat HEK293
    CD23, also known as Fc epsilon Receptor II (Fc epsilon RII), is a low-affinity receptor for immunoglobulin E (IgE) and complement receptor 2 (CR2/CD21). CD23 regulates IgE production and B-cell differentiation, aiding in IGE-dependent antigen uptake. CD23/Fc epsilon RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD23/Fc epsilon RII protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CD23/Fc epsilon RII Protein, Rat (HEK293, Fc) is 282 a.a., with molecular weight of 60-75 kDa.
  • HY-P74321
    CD23/Fc epsilon RII Protein, Mouse (HEK293, His)

    Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; FCER2; CD23A

    		Mouse HEK293
    CD23/Fc epsilon RII Protein, a low-affinity receptor for IgE and CR2/CD21, regulates IgE production and B cell differentiation. On B cells, it initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, IgE binding induces intracellular killing of parasites through the L-Arginine-nitric oxide pathway. CD23/Fc epsilon RII homotrimer interacts with IGHE to regulate IgE homeostasis and with CR2/CD21 for binding. CD23/Fc epsilon RII Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD23/Fc epsilon RII protein, expressed by HEK293 , with N-His labeled tag. The total length of CD23/Fc epsilon RII Protein, Mouse (HEK293, His) is 282 a.a., with molecular weight of 33-43 kDa.
Cat. No. Product Name Effect Purity