DEL D Kit Cyclic Peptide Library

Cat. No.: HY-LD005

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Cyclic peptide library have advantages such as high affinity, high selectivity, and suitability for targeting protein–protein interactions. Through DEL synthesis technology, the library size can achieve hundreds of millions. DEL cyclic peptide library have advantages like low cost andhigh screeing efficiency, making them valuable for discovering lead compounds against challenging drug targets.

This cyclic peptide library is constructed with unnatural amino acids as building block, synthesized through DNA-compatible chemical reactions. Each cyclic peptide consist of six amino acids and constrained conformations such as side-chain cross-linking, disulfide bonds, and macrocyclization. These cyclic peptides exhibit significantly improved stability and druggability compared with linear peptides, filling the gap between small molecules and macromolecular biologics. Each cyclic peptide is uniquely conjugated to a DNA barcode sequence for molecular identification and sequencing decoding.

MCE’s cyclic peptide library has8 independent sub-libraries, with a total molecular diversity of 1.2 billion. It is constructed via multi-round combinatorial assembly of building blocks and diverse cyclization strategies, facilitating the discovery of cyclic peptide leads for undruggable targets.

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Description & Advantages

• Each cyclic peptide sub-library contains 150 million molecules, with a total of 8 sub-libraries, suitable for DEL screening of cyclic peptide molecules.

• Standardized synthesis procedures and quality control protocols to ensure the reliability of compound chemical structures and the accuracy of encoding information, thereby guaranteeing the credibility of screening data.

• Ultra-large chemical space, suitable for new peptide drug discovery.

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Library Handling Instructions (351 KB)

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