1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

Microtubule/Tubulin

Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Microtubule/Tubulin Related Products (81):

Cat. No. Product Name Effect Purity
  • HY-B0015
    Paclitaxel Inhibitor 99.64%
    Paclitaxel is a potent anticancer agent known to promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-B0011
    Docetaxel Inhibitor 99.93%
    Docetaxel is a semi-synthetic taxane analogue, acts as a microtubule stabilizer.
  • HY-13520
    Nocodazole Inhibitor 99.05%
    Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, which exhibits good potency against ABL, ABL(E255K), and ABL(T315I) with IC50 values of 0.21 μM, 0.53 μM, and 0.64 μM, respectively, and increases CRISPR/Cas9-mediated editing frequencies.
  • HY-15162
    Monomethyl auristatin E Inhibitor 99.94%
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
  • HY-N0488
    Vincristine sulfate Inhibitor 99.51%
    Vincristine (sulfate) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
  • HY-N0227
    7-epi-Taxol Inhibitor 99.75%
    7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.
  • HY-19792
    Mertansine Inhibitor 98.74%
    Mertansine is a tubulin inhibitor,inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
  • HY-15575
    VcMMAE Inhibitor 99.89%
    VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
  • HY-16569
    Colchicine Inhibitor 99.56%
    Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine triggers apoptosis.
  • HY-15162A
    D8-MMAE Inhibitor 98.31%
    D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.
  • HY-13442A
    Eribulin mesylate Inhibitor 99.64%
    Eribulin (E7389;ER-086526) mesylate is a soft sponge B analogue that inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.
  • HY-15278
    Epothilone D Inhibitor 99.93%
    Epothilone D is a potent microtubule stabilizer.
  • HY-12033
    2-Methoxyestradiol Inhibitor 99.54%
    2-Methoxyestradiol is a microtubule and HIF-1 inhibitor, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro, works by interfering with normal microtubule function.
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
  • HY-17029
    Epothilone B Inhibitor 99.88%
    Epothilone B is a microtubule (MT) targeting agent with EC0.01 of 1.8 μM.
  • HY-15459
    Cabazitaxel Inhibitor 99.19%
    Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
  • HY-12053A
    Vinorelbine ditartrate Inhibitor 99.62%
    Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
  • HY-13780
    Vinblastine sulfate Inhibitor 99.87%
    Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
  • HY-15578
    McMMAF Inhibitor 99.47%
    Mc-MMAF is a protective group-conjugated MMAF.
  • HY-15584
    Taltobulin Inhibitor 99.90%
    Taltobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
Isoform Specific Products

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