1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

Microtubule/Tubulin

Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Microtubule/Tubulin Related Products (77):

Cat. No. Product Name Effect Purity
  • HY-B0015
    Paclitaxel Inhibitor 99.60%
    Paclitaxel is a potent anticancer agent known to promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.
  • HY-13520
    Nocodazole Inhibitor 99.05%
    Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, which exhibits good potency against ABL, ABL(E255K), and ABL(T315I) with IC50 values of 0.21 μM, 0.53 μM, and 0.64 μM, respectively, and increases CRISPR/Cas9-mediated editing frequencies.
  • HY-B0011
    Docetaxel Inhibitor 99.80%
    Docetaxel is a semi-synthetic taxane analogue, acts as a microtubule stabilizer.
  • HY-15162
    Monomethyl auristatin E Inhibitor 99.76%
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
  • HY-N0488
    Vincristine sulfate Inhibitor 99.40%
    Vincristine (sulfate) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM in a cell-free assay.
  • HY-12662
    PE859 Inhibitor 98.01%
    PE859 is a potent inhibitor of both tau and aggregation with IC50 values of 0.66 and 1.2 μM, respectively.
  • HY-12454
    DM4 Inhibitor 98.28%
    DM4 is is an antitubulin agent that inhibit cell division.
  • HY-15579S
    D8-MMAF Inhibitor
    D8-MMAF is a deuterated form of MMAF, which is a microtubule disrupting agent.
  • HY-15575
    VcMMAE Inhibitor 99.89%
    VcMMAE is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
  • HY-16569
    Colchicine Inhibitor 99.56%
    Colchicine is a tubulin inhibitor and a microtubule disrupting agent.
  • HY-19792
    Mertansine Inhibitor 98.22%
    Mertansine is a tubulin inhibitor,inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).
  • HY-12033
    2-Methoxyestradiol Inhibitor 99.54%
    2-Methoxyestradiol is a microtubule and HIF-1 inhibitor, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro, works by interfering with normal microtubule function.
  • HY-15459
    Cabazitaxel Inhibitor 99.19%
    Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine is a cytotoxic alkaloid used against various cancer types.
  • HY-12053A
    Vinorelbine ditartrate Inhibitor 99.62%
    Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM.
  • HY-15278
    Epothilone D Inhibitor 99.86%
    Epothilone D is a potent microtubule stabilizer.
  • HY-17029
    Epothilone B Inhibitor 99.85%
    Epothilone B is a microtubule (MT) targeting agent with EC0.01 of 1.8 μM.
  • HY-10222
    Ixabepilone Inhibitor
    Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors.
  • HY-15162A
    D8-MMAE Inhibitor 98.31%
    D8-MMAE is a deuterated form of MMAE, which is a microtubule-disrupting agent.
  • HY-13780
    Vinblastine sulfate Inhibitor 99.87%
    Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types.