1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. DM4

DM4 

Cat. No.: HY-12454 Purity: 98.80%
Handling Instructions

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.

For research use only. We do not sell to patients.

DM4 Chemical Structure

DM4 Chemical Structure

CAS No. : 796073-69-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 142 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 165 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate.

In Vitro

DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

780.37

Formula

C₃₈H₅₄ClN₃O₁₀S

CAS No.

796073-69-3

SMILES

C[[email protected]]1([[email protected]](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([[email protected]](C)N(C)C(CCC(C)(S)C)=O)=O)[[email protected]]([[email protected]@H]([[email protected]](OC4=O)([H])C[[email protected]]([[email protected]](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (128.14 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2814 mL 6.4072 mL 12.8144 mL
5 mM 0.2563 mL 1.2814 mL 2.5629 mL
10 mM 0.1281 mL 0.6407 mL 1.2814 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.20 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.80%

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Keywords:

DM4DM 4DM-4Microtubule/TubulinInhibitorinhibitorinhibit

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DM4
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