Secretin Receptor

SCTR

Secretin receptor (SCTR) is a G protein-coupled receptor (GPCR) which binds secretin. The secretin receptor has a 427-amino acid sequence and a molecular weight of 48,696 Da. The secretin receptor is related structurally to the receptors for VIP, parathyroid hormone (PTH), and calcitonin. Secretin receptors are expressed in the basolateral domain of several cell types. Secretin is a member of the secretin-glucagon family and is secreted by S cells of the duodenum in the small intestine. In addition to regulating the pH of the duodenal content by the control of gastric acid secretion, secretin regulates the secretion of bicarbonate ions into the duodenum from the epithelia lining the pancreatic and biliary ducts. Secretin has also been considered as a neuropeptide hormone since it is also expressed in the central nervous system (CNS). Recent evidence has indicated that secretin has pleiotropic effects in several organ systems (including the biliary epithelium) and has been termed a neuroendocrine hormone.

Secretin Receptor Related Products (8):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P1465A

Secretin (28-54), human TFA		98.62%
Secretin (28-54), human TFA is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-P1244A

Secretin (33-59), rat TFA		99.06%
Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K⁺ from the pancreas.

HY-P1465

Secretin (28-54), human
Secretin (28-54), human is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors.

HY-109538

Secretin (swine)
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.

HY-P1244

Secretin (33-59), rat
Secretin (33-59), rat is a 27-aa peptide, acts on secretin receptor, enhances the secretion of bicarbonate, enzymes, and K⁺ from the pancreas.

HY-P1535A

Secretin, porcine TFA
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.

HY-P1784

Secretin, canine
Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.

HY-P1535

Secretin, porcine
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.

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