1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Drug Metabolite

Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Drug Metabolite Related Products (48):

Cat. No. Product Name Effect Purity
  • HY-17366
    Clozapine N-oxide 99.98%
    Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system.
  • HY-13318
    Oseltamivir acid 99.54%
    Oseltamivir acid (GS 4071; Ro 64-0802; oseltamivir carboxylate), the ethyl ester prodrug of GS 4071, is an inhibitor of influenza virus neuraminidase with an IC50 of approximately 100 nM.
  • HY-100599
    Urolithin A 98.06%
    Urolithin A is an intestinal metabolite of ellagic acid with antioxidant and antiproliferative effects; inhibits T24 and Caco-2 cell growth with IC50 values of 43.9 and 49 μM, respectively.
  • HY-101107
    Allopregnanolone >98.0%
    Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor. Used to treat postpartum depression.
  • HY-101406
    Thyroxine sulfate >98.0%
    Thyroxine sulfate is a thyroid hormone metabolite.
  • HY-G0014B
    Quetiapine sulfoxide hydrochloride
    Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic.
  • HY-16445B
    CNDAC hydrochloride 99.53%
    CNDAC hydrochloride is a metabolite of the orally active agent sapacitabine, and a nucleoside analog.
  • HY-128828
    2-Hydroxy atorvastatin calcium salt
    2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM.
  • HY-12772
    Hydroxy Itraconazole 99.60%
    Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
  • HY-G0023
    Niraparib metabolite M1 99.85%
    Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
  • HY-103638
    3-Methoxytyramine hydrochloride >98.0%
    3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
  • HY-B1398
    Ampyrone 98.86%
    Ampyrone is a reagent for glucose determination in the presence of peroxidase and phenol.
  • HY-B1103
    Hydroxyhexamide 99.68%
    Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
  • HY-G0002A
    Lurasidone metabolite 14326 hydrochloride Chemical 98.76%
    Lurasidone metabolite 14326 (hydrochloride) is an active metabolite of the atypical antipsychotic Lurasidone.
  • HY-G0017
    Imatinib metabolite N-Desmethyl Imatinib
    Imatinib metabolite N-Desmethyl Imatinib (N-Desmethyl Imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR.
  • HY-B1180
    Vinburnine 99.78%
    Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
  • HY-103687
    Abiraterone metabolite 1 99.59%
    Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal drug, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
  • HY-100431A
    IMR-1A 98.23%
    IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitors with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A.
  • HY-100750
    Norverapamil hydrochloride 98.26%
    Norverapamil hydrochloride is a calcium channel blocker, it is the main active metabolite of verapamil.
  • HY-I0678
    Regorafénib N-oxyde M2 99.54%
    Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
Isoform Specific Products

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