1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Drug Metabolite

Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Drug Metabolite Related Products (64):

Cat. No. Product Name Effect Purity
  • HY-17366
    Clozapine (N-oxide) 99.98%
    Clozapine (N-oxide) is a pharmacologically inert metabolite of Clozapine, an antipsychotic drug. Clozapine (N-oxide) is a agonist for the DREADD (Designer Receptors Exclusively Activated by Designer Drug) system. Clozapine is a potent antagonist of dopamine. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
  • HY-13318
    Oseltamivir (acid) 99.54%
    Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
  • HY-100599
    Urolithin A 98.06%
    Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis.
  • HY-101107
    Allopregnanolone >98.0%
    Allopregnanolone is a progesterone metabolite. Allopregnanolone is an allosteric modulator of the GABA receptor. Used to treat postpartum depression.
  • HY-B0794A
    AZ7550 hydrochloride 98.02%
    AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
  • HY-16445B
    CNDAC hydrochloride 99.53%
    CNDAC hydrochloride is a metabolite of the orally active agent sapacitabine, and a nucleoside analog.
  • HY-128828
    2-Hydroxy atorvastatin calcium salt
    2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM.
  • HY-108251
    Methotrexate metabolite
    Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
  • HY-G0021
    N-Desmethylclozapine 99.72%
    N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic drug Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
  • HY-101406
    Thyroxine sulfate >98.0%
    Thyroxine sulfate is a thyroid hormone metabolite.
  • HY-32350
    Ercalcitriol 99.33%
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
  • HY-12772
    Hydroxy Itraconazole 99.60%
    Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
  • HY-18719B
    Endoxifen hydrochloride 98.32%
    Endoxifen hydrochloride, the active metabolite of Tamoxifen, is a potent antiestrogen that targets estrogen receptor.
  • HY-76801
    24, 25-Dihydroxy VD2 99.79%
    24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.
  • HY-100583A
    (±)-Equol 99.01%
    (±)-Equol is the racemate of equol. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.
  • HY-G0001A
    Lurasidone Metabolite 14283 hydrochloride 99.06%
    Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved drug for the treatment of schizophrenia.
  • HY-G0023
    Niraparib metabolite M1 99.74%
    Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
  • HY-103638
    3-Methoxytyramine hydrochloride >98.0%
    3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
  • HY-B1398
    Ampyrone 98.86%
    Ampyrone is a reagent for glucose determination in the presence of peroxidase and phenol.
  • HY-B1180
    Vinburnine 99.78%
    Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
Isoform Specific Products

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