1. Apoptosis
  2. TNF-alpha

TNF-alpha

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine. TNF-alpha can activate the NF-κB pathway by increasing the phosphorylation of IKK-α/β.

TNF-alpha is a negative regulator ofinsulin signal transduction. TNF-alpha is involved in regulating insulin resistance, obesity, as well as fatty acid (FA) and glucose metabolism. It has been confirmed that both adipose tissue and macrophages from activated adipose tissue secret TNF-alpha. The regulatory mechanisms of TNF-alpha on adipose tissue have been fully elucidated in mammals in the past decades. In addition, TNF-alpha is a limiting factor of lipid deposition in some fish species. TNF-alpha participates in regulating fat tissue mass in the gilthead sea bream (Sparusaurata L.), controlling adipose tissue lipid metabolism, and inhibiting the differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchusmykiss). TNF-alpha inhibits the expression of GSK-3β and induces β-catenin expression. TNF-alpha inhibits the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), as well as the activity of lipoprotein lipase (LPL) and fatty acid synthetase (FAS). In addition, the level of triglyceride (TG), total cholesterol (TC), nonesterified fatty acid (NEFA), and glycerol is decreased by TNF-alpha treatment in the liver.

TNF-alpha Related Products (19):

Cat. No. Product Name Effect Purity
  • HY-A0003
    Lenalidomide Inhibitor
    Lenalidomide is a potent inhibitor of TNF-α and has antiangiogenic effect.
  • HY-10984
    Pomalidomide Inhibitor
    Pomalidomide is a known inhibitor of TNF-α release in LPS stimulated human PBMC with IC50 of 13 nM.
  • HY-14622
    Necrostatin 2 Inhibitor
    Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
  • HY-15615A
    TIC10 Agonist
    TIC10 is a potent, orally active, and stable TRAIL inducer, also inhibits Akt and ERK activity.
  • HY-32018
    Cot inhibitor-2 Inhibitor
    Cot inhibitor-2 is a COT/Tpl2 inhibitor.
  • HY-N2027
    Taurochenodeoxycholic acid Inhibitor
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
  • HY-100735
    C 87 Inhibitor
    C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
  • HY-14622A
    Necrostatin 2 racemate Inhibitor
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  • HY-A0003B
    Lenalidomide hemihydrate Inhibitor
    Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
  • HY-N0724
    Mesaconitine Inhibitor
    Mesaconitine is the main active component of genus aconitum plants.
  • HY-14622B
    Necrostatin 2 S enantiomer Inhibitor
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  • HY-19717
    DCVC Inhibitor
    DCVC inhibits pathogen-stimulated TNF-(alpha) in human extra placental membranes in vitro.
  • HY-32015
    Cot inhibitor-1 Inhibitor
    Cot inhibitor-1 is a COT/Tpl2 inhibitor.
  • HY-N0297
    Sinensetin Inhibitor
    Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
  • HY-18377
    Bioymifi Activator
    Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.
  • HY-N0267
    Hypaconitine Inhibitor
    Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.
  • HY-13743
    Roquinimex Inhibitor
    Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.
  • HY-N0619
    Mulberroside A Inhibitor
    Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L. (Moraceae), is widely employed as an active ingredient in whitening cosmetics.
  • HY-A0003A
    Lenalidomide hydrochloride Inhibitor
    Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.