1. Apoptosis
  2. TNF-alpha

TNF-alpha

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine. TNF-alpha can activate the NF-κB pathway by increasing the phosphorylation of IKK-α/β.

TNF-alpha is a negative regulator ofinsulin signal transduction. TNF-alpha is involved in regulating insulin resistance, obesity, as well as fatty acid (FA) and glucose metabolism. It has been confirmed that both adipose tissue and macrophages from activated adipose tissue secret TNF-alpha. The regulatory mechanisms of TNF-alpha on adipose tissue have been fully elucidated in mammals in the past decades. In addition, TNF-alpha is a limiting factor of lipid deposition in some fish species. TNF-alpha participates in regulating fat tissue mass in the gilthead sea bream (Sparusaurata L.), controlling adipose tissue lipid metabolism, and inhibiting the differentiation of adipocyte precursor cells in rainbow trout (Oncorhynchusmykiss). TNF-alpha inhibits the expression of GSK-3β and induces β-catenin expression. TNF-alpha inhibits the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), as well as the activity of lipoprotein lipase (LPL) and fatty acid synthetase (FAS). In addition, the level of triglyceride (TG), total cholesterol (TC), nonesterified fatty acid (NEFA), and glycerol is decreased by TNF-alpha treatment in the liver.

TNF-alpha Related Products (22):

Cat. No. Product Name Effect Purity
  • HY-A0003
    Lenalidomide Inhibitor 99.98%
    Lenalidomide is a potent inhibitor of TNF-α and has antiangiogenic effect.
  • HY-10984
    Pomalidomide Inhibitor >98.0%
    Pomalidomide is a known inhibitor of TNF-α release in LPS stimulated human PBMC with IC50 of 13 nM.
  • HY-15615A
    TIC10 Agonist 99.79%
    TIC10 is a potent, orally active, and stable TRAIL inducer, also inhibits Akt and ERK activity.
  • HY-14622
    Necrostatin 2 Inhibitor 99.89%
    Necrostatin 2 is a potent necroptosis inhibitor.
  • HY-32018
    Cot inhibitor-2 Inhibitor 99.20%
    Cot inhibitor-2 is a COT/Tpl2 inhibitor.
  • HY-100735
    C 87 Inhibitor >98.0%
    C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.
  • HY-N2027
    Taurochenodeoxycholic acid Inhibitor 99.80%
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.
  • HY-N1949
    Homoplantaginin Inhibitor 99.61%
    Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinfammatory and antioxidant properties.
  • HY-A0003B
    Lenalidomide hemihydrate Inhibitor 99.82%
    Lenalidomide hemihydrate is a potent inhibitor of TNF-α and has antiangiogenic effect.
  • HY-14622A
    Necrostatin 2 racemate Inhibitor 98.43%
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.
  • HY-N0724
    Mesaconitine Inhibitor 99.55%
    Mesaconitine is the main active component of genus aconitum plants.
  • HY-19717
    DCVC Inhibitor 99.37%
    DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.
  • HY-15615
    TIC10 isomer 99.61%
    TIC10 isomer(ONC201 isomer) is an isomer of TIC10; TIC10 is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
  • HY-32015
    Cot inhibitor-1 Inhibitor
    Cot inhibitor-1 is a COT/Tpl2 inhibitor.
  • HY-14622B
    Necrostatin 2 S enantiomer Inhibitor 98.73%
    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  • HY-18377
    Bioymifi Activator
    Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.
  • HY-N0029
    Forsythoside B 99.63%
    Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation.
  • HY-A0003A
    Lenalidomide hydrochloride Inhibitor
    Lenalidomide hydrochloride is a potent inhibitor of TNF-α and has antiangiogenic effect.
  • HY-N0267
    Hypaconitine Inhibitor
    Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.