Signaling Pathway

TNF-alpha

TNF-alpha

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TNF-alpha Inhibitors & Modulators (17)

Product Name Catalog No. Brief Description
Bioymifi

HY-18377

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.

Cot inhibitor-1

HY-32015

Cot inhibitor-1 is a COT/Tpl2 inhibitor.

Cot inhibitor-2

HY-32018

Cot inhibitor-2 is a COT/Tpl2 inhibitor.

DCVC

HY-19717

DCVC  inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

Hypaconitine

HY-N0267

Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism.

Lenalidomide

HY-A0003

Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

Lenalidomide hemihydrate

HY-A0003B

Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

Lenalidomide hydrochloride

HY-A0003A

Description:
IC50 Value: 13 nM [1]
Lenalidomideis a derivative of thalidomide introduced in 2004.

Mesaconitine

HY-N0724

Mesaconitine is the main active component of genus aconitum plants.

Mulberroside A

HY-N0619

Mulberroside A, the major active anti-tyrosinase compound in the root bark extract of Morus alba L.

Necrostatin 2

HY-14622

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Necrostatin 2 racemate

HY-14622A

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Necrostatin 2 S enantiomer

HY-14622B

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Necrostatin-1

HY-15760

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.

Pomalidomide

HY-10984

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM.

Roquinimex

HY-13743

Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.

Sinensetin

HY-N0297

Sinensetin is a methylated flavone found in certain citrus fruits.