2. Immunology/Inflammation Apoptosis NF-κB
  3. Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
  4. Muscone

Muscone 

Cat. No.: HY-N0633 Purity: ≥98.0%
COA Handling Instructions

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

For research use only. We do not sell to patients.

Muscone Chemical Structure

Muscone Chemical Structure

CAS No. : 541-91-3

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Customer Review

Based on 5 publication(s) in Google Scholar

Muscone Related Antibodies

Top Publications Citing Use of Products

    Muscone purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2023 Mar 5.

    Muscone (8 mg/kg; i.p.; once a day for 7 consecutive days) obviously reduces the infarct volume in mice.

    Muscone purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2023 Mar 5.

    Muscone (8 mg/kg; i.p.; once a day for 7 consecutive days) significantly decreases the expression levels of pro-inflammatory proteins including TNF-α, IL-1β and IL-6 in mice distal middle cerebral artery occlusion (dMCAO) model.

    View All NF-κB Isoform Specific Products:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • Biological Activity

    • Purity & Documentation

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    Description

    Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].

    IC50 & Target[1]

    NF-κB

     

    NLRP3

     

    IL-1β

     

    IL-6

     

    In Vitro

    Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs).??Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Muscone Related Antibodies
    Molecular Weight

    238.41

    Appearance

    Liquid

    Formula

    C16H30O
    CAS No.
    SMILES

    O=C1CC(C)CCCCCCCCCCCC1
    Structure Classification
    Initial Source

    musk
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (419.45 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.1945 mL 20.9723 mL 41.9445 mL
    5 mM 0.8389 mL 4.1945 mL 8.3889 mL
    10 mM 0.4194 mL 2.0972 mL 4.1945 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: ≥98.0%

    COA (252 KB) HNMR (192 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References
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    Muscone Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Muscone541-91-3Interleukin RelatedTNF ReceptorNF-κBNOD-like Receptor (NLR)ILTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBanti-inflammationmyocardialinfarctionmacrophageNLRP3inflammasomeIL-1βTNF-αIL-6Inhibitorinhibitorinhibit

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