1. Immunology/Inflammation
    Apoptosis
    NF-κB
  2. Interleukin Related
    TNF Receptor
    NF-κB
    NOD-like Receptor (NLR)
  3. Muscone

Muscone 

Cat. No.: HY-N0633 Purity: >98.0%
Handling Instructions

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

For research use only. We do not sell to patients.

Muscone Chemical Structure

Muscone Chemical Structure

CAS No. : 541-91-3

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Estimated Time of Arrival: December 31
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Description

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].

IC50 & Target[1]

NF-κB

 

NLRP3

 

TNF-α

 

IL-1β

 

IL-6

 

In Vitro

Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs).  Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1].

Molecular Weight

238.41

Formula

C₁₆H₃₀O

CAS No.

541-91-3

SMILES

O=C1CC(C)CCCCCCCCCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1048.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1945 mL 20.9723 mL 41.9445 mL
5 mM 0.8389 mL 4.1945 mL 8.3889 mL
10 mM 0.4194 mL 2.0972 mL 4.1945 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (26.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (26.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MusconeInterleukin RelatedTNF ReceptorNF-κBNOD-like Receptor (NLR)ILTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBanti-inflammationmyocardialinfarctionmacrophageNLRP3inflammasomeIL-1βTNF-αIL-6Inhibitorinhibitorinhibit

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Muscone
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HY-N0633
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