Search Result

Results for "

IL-6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (88) IRAK (2) Adenosine Receptor (2) Adrenergic Receptor (3) Akt (2) Amyloid-β (1) Antibiotic (2) AP-1 (1) Apoptosis (16) Autophagy (9) Bacterial (10) Bcl-2 Family (1) Beta-lactamase (1) Bradykinin Receptor (2) Btk (1) Calcium Channel (2) Cannabinoid Receptor (2) Caspase (7) CD6 (1) CDK (1) Cholinesterase (ChE) (3) COX (16) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Endogenous Metabolite (24) Enterovirus (3) Epigenetic Reader Domain (2) ERK (4) Estrogen Receptor/ERR (12) Ferroptosis (2) Formyl Peptide Receptor (FPR) (3) Fungal (1) FXR (1) Glucocorticoid Receptor (13) Glutathione Peroxidase (1) HCV (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (1) HMG-CoA Reductase (HMGCR) (1) IFNAR (2) IGF-1R (1) IKK (1) Influenza Virus (2) Integrin (2) IRE1 (2) Isotope-Labeled Compounds (12) JAK (5) JNK (4) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) Leukotriene Receptor (1) Lipoxygenase (4) MALT1 (2) MAP4K (2) MAPKAPK2 (MK2) (2) MEK (1) MMP (2) Monoamine Oxidase (2) mTOR (1) nAChR (2) Neurokinin Receptor (2) NF-κB (34) NO Synthase (12) NOD-like Receptor (NLR) (6) Nucleoside Antimetabolite/Analog (1) Oxidative Phosphorylation (1) P2Y Receptor (1) p38 MAPK (8) Parasite (1) PGE synthase (2) Phosphodiesterase (PDE) (3) Phospholipase (2) PI3K (1) PKC (1) Potassium Channel (7) PPAR (4) Prostaglandin Receptor (1) PROTACs (2) Protease Activated Receptor (PAR) (2) Proteasome (1) Reactive Oxygen Species (8) RIP kinase (1) ROR (1) ROS Kinase (1) SARS-CoV (9) Sigma Receptor (2) Small Interfering RNA (siRNA) (5) STAT (18) STING (6) TGF-β Receptor (1) TNF Receptor (42) Toll-like Receptor (TLR) (23) TSH Receptor (1) Tyrosinase (2) VEGFR (5) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (74) Cardiovascular Disease (15) Endocrinology (15) Infection (30) Inflammation/Immunology (227) Metabolic Disease (10) Neurological Disease (20)
Click Chemistry:	Alkynes (1)

295

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

IL-6 aptamer sodium	Interleukin Related	Cancer
IL-6 aptamer sodium is a nucleic acid aptamer that specifically targets *IL-6* and can be used for the specific detection of IL-6 .

IL6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL6 Human Pre-designed siRNA Set A contains three designed siRNAs for IL6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL6R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL6R Human Pre-designed siRNA Set A contains three designed siRNAs for IL6R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL6ST Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL6ST Human Pre-designed siRNA Set A contains three designed siRNAs for IL6ST gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

*Interleukin (IL)-6* Receptor**	Interleukin Related	Others
Interleukin (IL)-6 Receptor is a peptide, derived from interleukin-6 receptor.

Elsilimomab B-E8; Anti-IL-6 MAB B-E8; Anti-Human IL6 Recombinant Antibody	Interleukin Related	Inflammation/Immunology Cancer
Elsilimomab (B-E8) is a IgG1 monoclonal antibody against **interleukin-6 (IL-6), with a K_D of 22 pM and an IC₅₀** of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA) .

Sarilumab Anti-Human IL6Rα, Human Antibody	Interleukin Related	Inflammation/Immunology Cancer
Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis .

Tocilizumab 15+ Cited Publications Anti-Human IL6R, Humanized Antibody	Interleukin Related	Inflammation/Immunology Cancer
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .

Episappanol	TNF Receptor Interleukin Related	Inflammation/Immunology
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the *IL-6* and TNF-α secretion .

Di-O-methyldemethoxycurcumin	Interleukin Related	Inflammation/Immunology
Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits *IL-6* production with an EC₅₀ of 16.20 μg/mL. Anti-inflammatory and antioxidant properties .

Y13g	Cholinesterase (ChE) Interleukin Related	Neurological Disease
Y13g is the potent inhibitor of both AChE and *IL-6. Interleukin-6 (IL-6*) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g reverses the STZ-induced memory deficit, and shows histopathology similarly as in normal animals .

Y13g dihydrochloride	Interleukin Related Cholinesterase (ChE)	Neurological Disease
Y13g dihydrochloride is the potent inhibitor of both AChE and *IL-6. Interleukin-6 (IL-6*) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g dihydrochloride reverses the STZ-induced memory deficit, and shows histopathology similarly as in normal animals .

Anti-inflammatory agent 76	NO Synthase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, IL-1β and *IL-6* inhibitory activities .

HP210	Glucocorticoid Receptor	Inflammation/Immunology
HP210 is a selective glucocorticoid receptor modulator (SGRM). HP210 can inhibit the mRNA expression of IL-1β and IL-6. HP210 has the potential to study inflammation-related diseases .

Anti-inflammatory agent 77	Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 77 (C12) is a β-cycloacinamide derived mono-carbonyl curcumin analog and an inhibitor of interleukin-6 (IL-6). Anti-inflammatory agent 77 can be used in the study of wound healing .

Linderaspirone A	PGE synthase Interleukin Related	Inflammation/Immunology
Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .

GNE-2256	IRAK	Inflammation/Immunology
GNE-2256 (molecule 19) is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 K_i=1.4 nM; IL-6 IC₅₀=190 nM) .

ODN 2088	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .

ODN 2088 sodium	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
ODN 2088 sodium is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 sodium shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .

Angoline 1 Publications Verification	STAT	Cancer
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

Angoline hydrochloride	STAT	Cancer
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC₅₀ of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and *IL-6* in vitro .

Anti-inflammatory agent 41	Interleukin Related TNF Receptor NF-κB	Inflammation/Immunology
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines *IL-6* and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway .

IL-17 modulator 2	Interleukin Related	Inflammation/Immunology
IL-17 modulator 2 (compound 159) is an orally active modulator of IL-17. IL-17 modulator 2 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 2 can used in study arthritis .

IL-17 modulator 8	Interleukin Related	Inflammation/Immunology
IL-17 modulator 8 (compound 286) is an orally active modulator of IL-17. IL-17 modulator 8 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 8 can used in study arthritis .

IL-17 modulator 9	Interleukin Related	Inflammation/Immunology
IL-17 modulator 9 (compound 453) is an orally active modulator of IL-17. IL-17 modulator 9 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 9 can used in study inflammation .

Taurohyodeoxycholic acid sodium 1 Publications Verification	Interleukin Related TNF Receptor	Inflammation/Immunology
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

Agatolimod ODN 2006; PF-3512676; CpG 7909; ODN 7909	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Agatolimod (ODN 2006), a class B ODN (oligodeoxynucleotide), is a TLR9 agonist. Agatolimod is also an optimal CpG sequence for humans. Agatolimod stimulates very strong production of NO₂ and IL-6 in HD11 cells. Agatolimod can be used for breast cancer research. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3' .

ODN 21595	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21595 is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 reduces the expression of CD86 and HLA-DR. ODN 21595 has the potential for the research of systemic lupus erythematosus (SLE) .

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

ODN 21595 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21595 sodium is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 sodium inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 sodium reduces the expression of CD86 and HLA-DR. ODN 21595 sodium has the potential for the research of systemic lupus erythematosus (SLE) .

Atrosab	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated apoptosis induction and IL-6 and IL-8 production. Atrosab can be used for research of inflammatory disease .

iNOs-IN-1 1 Publications Verification	NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .

PROTAC BTK Degrader-6	PROTACs Btk	Inflammation/Immunology
PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC₅₀: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6) .

Isoforskolin Coleonol B	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, *IL-6* and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

BMS905	Toll-like Receptor (TLR)	Inflammation/Immunology
BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC₅₀s: 0.7 and 3.2 nM respectively). BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus .

Anti-inflammatory agent 64	ROS Kinase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 64 (compound 4b) inhibits the secretion of *IL-6* and TNF-α. Anti-inflammatory agent 64 has antioxidant and anti-inflammatory activity in vitro and in vivo. Anti-inflammatory agent 64 can effectively reduce paw edema .

SIMR3030	SARS-CoV	Infection
SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC₅₀ value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice .

Muscone 3 Publications Verification	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and *IL-6*), and ultimately improves cardiac function and survival rate .

NOD2 antagonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .

α-Chaconine	COX	Inflammation/Immunology
α-Chaconine inhibits the expressions of COX-2, IL-1β, *IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

Hydrocortisone phosphate Hydrocortisone 21-phosphate; Cortisol 21-phosphate	Glucocorticoid Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC).

Emprumapimod PF-07265803	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Emprumapimod (PF-07265803) is a potent, orally active and selective inhibitor of p38α MAPK directly inhibits LPS-induced IL-6 production from RPMI-8226 cell (IC₅₀=100 pM). Emprumapimod can be used for the research of dilated cardiomyopathy and acute inflammatory pain .

Chlojaponilactone B	Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB	Inflammation/Immunology
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α .

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

457 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 457 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Cat. No.	Product Name	Type

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Biochemical Assay Reagents
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-113066C

Guanosine 5'-diphosphate sodium

GDP sodium

Biochemical Assay Reagents

Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate sodium is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate sodium can be used in the research of inflammation, such as anemia of inflammation (AI) .

Cat. No.	Product Name	Target	Research Area

HY-P0317

Interleukin (IL)-6 Receptor

Interleukin Related Others

Interleukin (IL)-6 Receptor is a peptide, derived from interleukin-6 receptor.

HY-P3412

MMI-0100	MAPKAPK2 (MK2)	Inflammation/Immunology
MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .

HY-122767

Romurtide Muroctasin	Interleukin Related	Inflammation/Immunology
Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and *IL-6* in vitro .

HY-P5836

Citrullinated LL-37 1cit	Interleukin Related Bacterial Enterovirus	Inflammation/Immunology
Citrullinated LL-37 1cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 1cit does not alter the antiviral effect of LL-37 toward human rhinovirus. Citrullinated LL-37 1cit shows antibacterial activity toward S. aureus. Citrullinated LL-37 1cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B .

HY-P5837

Citrullinated LL-37 2cit	Interleukin Related Enterovirus	Inflammation/Immunology
Citrullinated LL-37 2cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 2cit reduces LL-37 activity against HRV at 10 μg/mL and reduces the antibacterial effect of LL-37. Citrullinated LL-37 2cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B. Citrullinated LL-37 2cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion .

HY-P1117

MMK1	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin (HY-112779)-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P5838

Citrullinated LL-37 5cit	Peptides	Inflammation/Immunology
Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrullinated LL-37 5cit are significantly reduced compared to native LL-37. Citrullinated LL-37 5cit is unable to reduce LPS-mediated release of TNF-α due to a lack of LPS-binding capacity .

HY-P5843

Citrullinated LL-37 4cit	Enterovirus	Infection
Citrullinated LL-37 3cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 3cit lacks all antiviral activity at 10 μg/mL and retains some activity against HRV at 30 μg/mL. Citrullinated LL-37 3cit reduces the immunomodulatory activity of LL-37. Citrullinated LL-37 3cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion .

HY-P5227

Acetyl hexapeptide-49	Interleukin Related	Inflammation/Immunology
Acetyl hexapeptide-49 is a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient .

HY-P2320

IDR-1	Bacterial	Infection Inflammation/Immunology
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release .

Cat. No.	Product Name	Target	Research Area

HY-P99287

Elsilimomab B-E8; Anti-IL-6 MAB B-E8; Anti-Human IL6 Recombinant Antibody	Interleukin Related	Inflammation/Immunology Cancer
Elsilimomab (B-E8) is a IgG1 monoclonal antibody against **interleukin-6 (IL-6), with a K_D of 22 pM and an IC₅₀** of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA) .

HY-P9916

Sarilumab Anti-Human IL6Rα, Human Antibody	Interleukin Related	Inflammation/Immunology Cancer
Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis .

HY-P9917

Tocilizumab 15+ Cited Publications Anti-Human IL6R, Humanized Antibody	Interleukin Related	Inflammation/Immunology Cancer
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .

HY-P990008

Atrosab	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated apoptosis induction and IL-6 and IL-8 production. Atrosab can be used for research of inflammatory disease .

HY-P990212

Anti-Mouse IL-6 Antibody (MP5-20F3)

Inhibitory Antibodies Others

Anti-Mouse IL-6 Antibody (MP5-20F3) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-6.
HY-P990211

Anti-Mouse IL-6R Antibody (15A7)

Inhibitory Antibodies Others

Anti-Mouse IL-6R Antibody (15A7) is a rat-derived IgG2b, κ type antibody inhibitor, targeting to mouse IL-6R.

HY-P99210

Olokizumab CDP 6038; OKZ	Interleukin Related	Inflammation/Immunology
Olokizumab (CDP 6038) is a humanized monoclonal antibody targeting the **interleukin-6 (IL-6)**. Olokizumab can be used in research of rheumatoid arthritis (RA) .

HY-P990012

Vamikibart

Interleukin Related Inflammation/Immunology

Vamikibart is a chimeric humanized IgG2κ antibody targeting IL6 .

HY-P99112

Satralizumab	Interleukin Related	Inflammation/Immunology Cancer
Satralizumab, a humanized monoclonal antibody, is a potent **Interleukine-6 (IL-6)** inhibitor. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .

HY-P99012

Clazakizumab	Interleukin Related SARS-CoV	Infection Inflammation/Immunology
Clazakizumab is a monoclonal antibody with high affinity and specificity for the *IL-6* (interleukin-6) cytokine. Clazakizumab may be helpful in inhibiting the cytokine response to SARS-CoV-2 in COVID-19. Clazakizumab can be used for the research of psoriatic arthritis (PsA) and renal antibody-mediated rejection .

HY-P99336

Enlimomab BI-RR 0001; Anti-Human IL6 Recombinant Antibody	Integrin	Neurological Disease Inflammation/Immunology
Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research .

HY-P99316

Sirukumab CNTO-136	Interleukin Related	Inflammation/Immunology
Sirukumab (CNTO-136) is a human monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab has the potential for active lupus nephritis research .

HY-P99252

Itolizumab Anti-Human CD6 Recombinant Antibody	CD6	Infection Inflammation/Immunology
Itolizumab (Anti-Human CD6 Recombinant Antibody) is a humanized recombinant *anti-CD6* monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19 .

HY-P99111

Golimumab CNTO-148	TNF Receptor Apoptosis Interleukin Related Caspase	Inflammation/Immunology Cancer
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research .

HY-P99165

Teprotumumab	IGF-1R TSH Receptor	Endocrinology
Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .

HY-P99505

Ziltivekimab COR-001	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Ziltivekimab (COR-001) is a human anti-IL-6 monoclonal antibody that is effective in reducing serum CRP. Ziltivekimab has anti-inflammatory activity and may be used in studies of chronic systemic inflammation and cardiovascular disease associated with CKD .

HY-P99702

Levilimab BCD-089	Interleukin Related	Inflammation/Immunology
Levilimab (BCD-089) is a fully humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody. Levilimab is an inflammation-alleviating antibody. Levilimab can be used for the research of rheumatoid .

HY-P99385

Vobarilizumab ALX-0061	Interleukin Related	Inflammation/Immunology
Vobarilizumab (ALX-0061) is an anti-IL-6R monoclonal antibody (mAb) (K_d: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis .

HY-P9956

Siltuximab CNTO-328	Interleukin Related	Cancer
Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research .

HY-108810

Canakinumab ILaris; ACZ 885	Interleukin Related	Inflammation/Immunology
Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC₅₀ values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin .

HY-P99408

Oxelumab R 4930; huMAb OX 40L; Ro 49-89991	Interleukin Related	Inflammation/Immunology
Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma .

HY-P9950

Omalizumab 1 Publications Verification Olizumab; rhuMab-E25	Inhibitory Antibodies	Inflammation/Immunology Cancer
Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K_D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K_D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research .

HY-P99590

Sotatercept ACE-011	TGF-β Receptor	Inflammation/Immunology Cancer
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions .

Recombinant Proteins Recommended:

IL-6

Species:	Human (17) Rhesus Macaque (4) Mouse (9) Rat (5) Cynomolgus (1) Rabbit (1) Pig (2) Canine (1)
Tag:	His (24) Tag Free (10) Avi (3) Myc (1) Fc (7)
Source:	HEK293 (24) CHO (3) P. pastoris (1) Sf9 insect cells (1) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P7044AF

	*Animal-Free IL-6* Protein, Human (His)** Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2	Human	E. coli
	IL-6 protein is a multifunctional cytokine that plays multiple biological functions in immunity, tissue regeneration, and metabolism. After binding to IL6R, the resulting complex binds to the signaling subunit IL6ST/gp130, triggering the intracellular IL6 signaling pathway. Animal-Free IL-6 Protein, Human (His) is the recombinant human-derived animal-FreeIL-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-6 Protein, Human (His) is 184 a.a., with molecular weight of ~21.8 kDa.

HY-P7044G

	*GMP IL-6* Protein, Human** 1 Publications Verification Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2	Human	E. coli
	IL-6 protein is a multifunctional cytokine that plays multiple biological functions in immunity, tissue regeneration, and metabolism. After binding to IL6R, the resulting complex binds to the signaling subunit IL6ST/gp130, triggering the intracellular IL6 signaling pathway. GMP IL-6 Protein, Human is the recombinant human-derived IL-6 protein, expressed by E. coli , with tag free. GMP IL-6 Protein, Human, has molecular weight of ~20.0 kDa.

HY-P7222

	IL-6 Protein, Rhesus macaque rRhIL-6; IL6	Rhesus Macaque	E. coli
	IL-6 Protein, Rhesus macaque is a inflammatory related and immunoregulatory cytokine contributing to host defense against infections and tissue injuries.

HY-P78854

	IL-6 Protein, Human (Biotinylated) IL6; Interleukin-6; BSF2; HSF; IFNB2	Human	HEK293
	IL-6 protein is a multifunctional cytokine that plays multiple biological functions in immunity, tissue regeneration, and metabolism. After binding to IL6R, the resulting complex binds to the signaling subunit IL6ST/gp130, triggering the intracellular IL6 signaling pathway. IL-6 Protein, Human (Biotinylated) is the recombinant human-derived IL-6 protein, expressed by HEK293 , with N-Avi labeled tag. The total length of IL-6 Protein, Human (Biotinylated) is 183 a.a., with molecular weight of 27-30 kDa.

HY-P7378

	IL-6 Protein, Mouse (CHO, His) rMuIL-6, His; B cell differentiation factor; IL6	Mouse	CHO
	IL-6 Protein, Mouse (CHO, His) is a multifunctional cytokine that can regulate various immune and inflammatory responses.

HY-P7063

	IL-6 Protein, Mouse rMuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2	Mouse	E. coli
	IL-6 Protein, Mouse is a multifunctional cytokine that can regulate various immune and inflammatory responses.

HY-P7044

	IL-6 Protein, Human Maximum Cited Publications 23 Publications Verification rHuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2	Human	E. coli
	IL-6 Protein, Human is a potent inducer of the synthesis of acute phase proteins in adult human hepatocytes.

HY-P73220

	IL-6 Protein, Pig Interleukin-6; Interleukin HP-1; BSF2; HSF; IFNB2	Pig	E. coli
	IL-6 protein is a multifunctional cytokine that participates in immune, regenerative and metabolic processes by binding to IL6R and forming a complex with IL6ST/gp130. This activates the IL6 signaling pathway, initiating "classical signaling" via membrane-bound IL6R and IL6ST, "trans signaling" via binding of IL6 and soluble IL6R to IL6ST, and "cluster signaling" via the IL6:IL6R complex ". IL-6 Protein, Pig is the recombinant pig-derived IL-6 protein, expressed by E. coli , with tag free. The total length of IL-6 Protein, Pig is 184 a.a., with molecular weight of ~21.2 kDa.

HY-P7044A

	IL-6 Protein, Human (CHO) 1 Publications Verification rHuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2	Human	CHO
	IL-6 Protein, Human (CHO) is a potent inducer of the synthesis of acute phase proteins in adult human hepatocytes.

HY-P700749

	IL-6 Protein, Cynomolgus (HEK293, His) IFN-beta-2; IL6; IL-6; BSF-2; CDF; MGI-2A; Interleukin-6; HSF; IFNB2; HGF; IFN-β-2	Cynomolgus	HEK293
	IL-6 is a cytokine with multiple functions in immunity, tissue regeneration, and metabolism, coordinating complex signaling. Binding to IL6R initiates the IL6 signaling pathway through a complex with the signaling subunit IL6ST/gp130. IL-6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-6 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-6 Protein, Cynomolgus (HEK293, His) is 185 a.a., with molecular weight of 25-30 kDa.

HY-P7103A

	IL-6 Protein, Rat (HEK293) 2 Publications Verification rRtIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2	Rat	HEK293
	IL-6 Protein, Rat (HEK293) is a HEK293 cell derived multifunctional cytokine that can regulate various immune and inflammatory responses.

HY-P702586

IL-6 Protein, Rabbit (P.pastoris, His)

Interleukin-6
Rabbit P. pastoris

HY-P7063A

	IL-6 Protein, Mouse (His) rMuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2	Mouse	E. coli
	IL-6 protein is involved in various functions such as immunity, tissue regeneration and metabolism. IL-6 Protein, Mouse (His) is the recombinant mouse-derived IL-6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-6 Protein, Mouse (His) is 187 a.a., with molecular weight of ~24 kDa.

HY-P7044B

	IL-6 Protein, Human (N-His) rHuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2	Human	E. coli
	IL-6 protein is a multifunctional cytokine that plays multiple biological functions in immunity, tissue regeneration, and metabolism. After binding to IL6R, the resulting complex binds to the signaling subunit IL6ST/gp130, triggering the intracellular IL6 signaling pathway. IL-6 Protein, Human (N-His) is the recombinant human-derived IL-6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of IL-6 Protein, Human (N-His) is 184 a.a., with molecular weight of ~21 kDa.

HY-P78472

	IL-6R alpha Protein, Human (HEK293, His-Avi) IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; IL6R; CD126; IL6RQ; gp80	Human	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha Protein, Human (L20-P365) is soluble form and expressed by HEK293 cells with a C-Terminal Avi-tag and a C-Terminal His-tag.

HY-P7223

	IL-6R alpha Protein, Human (CHO) 1 Publications Verification rHuIL-6R; IL-6RA; IL-6R 1; CD126; Membrane glycoprotein 80	Human	CHO
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha Protein, Human (L20-P365) is soluble form and expressed by CHO cells with a full length of the sequence of 346 amino acids.

HY-P73221

	IL-6R Protein, Canine (HEK293, His) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126	Canine	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha, Canine consists of 462 amino acids (M1-R462) and is produced in HEK293 cells with a C-Terminal His-tag.

HY-P73224

	IL-6R Protein, Rat (HEK293, His) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126	Rat	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha, Rat consists of 462 amino acids (M1-R462) with a fibronectin type-III-like domain contained in the N-terminal part (215-313 a.a) and a transmembrane domain (365-385 a.a). Soluble IL-6R (sIL-6R) interacts with SORL1 to conduct internalization and binds IL-6 and dimerized gp130 to deliver trans signalin. IL-6R alpha, Rat (I44-E357) is soluble form and produced in HEK293 cells with a C-Terminal His-tag.

HY-P73876

	IL-6R Protein, Rat (HEK293, Fc) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126	Rat	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha, Rat consists of 462 amino acids (M1-R462) with a fibronectin type-III-like domain contained in the N-terminal part (215-313 a.a) and a transmembrane domain (365-385 a.a). Soluble IL-6R (sIL-6R) interacts with SORL1 to conduct internalization and binds IL-6 and dimerized gp130 to deliver trans signalin. IL-6R alpha, Rat (I44-E357) is soluble form and produced in HEK293 cells with a C-Terminal hFc-tag.

HY-P78781

	*gp130/IL6ST Protein, Mouse (595a.a, HEK293, His)* IL6ST; gp130; CD130; IL-6RB; IL-6R-beta; CDw130	Mouse	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Mouse (595a.a, HEK293, His) is a recombinant protein with a His label that consists of 595 amino acids (Q23-E617) and is produced by HEK293 cells.

HY-P73222

	IL-6R alpha Protein, Human (HEK293, Fc) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126	Human	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha Protein, Human (M1-P365) is soluble form and produced in HEK293 cells with a C-Terminal hFc-tag.

HY-P73225

	IL-6R Protein, Rhesus Macaque (HEK293, His) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126	Rhesus Macaque	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha, Rhesus Macaque consists of 365 amino acids (M1-P365) and is produced in HEK293 cells with a C-Terminal His-tag.

HY-P70515

	IL-6R alpha Protein, Human (339a.a, HEK293, His) Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6R 1; Membrane glycoprotein 80; gp80; CD126	Human	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha, Human (L20-D358) is soluble form and produced in HEK293 cells with a C-Terminal His-tag.

HY-P72388

	IL-6R alpha Protein, Human (Biotinylated, HEK293, Avi-His) Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6R 1; Membrane glycoprotein 80; gp80; CD126	Human	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha Protein, Human (L20-P365) is soluble and biotinylated recombinant protein expressed by HEK293 cells with a C-Terminal Avi-tag and a C-Terminal His-tag.

HY-P73877

	IL-6R alpha Protein, Mouse (314a.a, HEK293, His) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; gp80; CD126	Mouse	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha, Mouse consists of 460 amino acids (M1-R460) with two fibronectin type-III-like domains contained in the N-terminal part (109-214 a.a, 215-313 a.a). Soluble IL-6R (sIL-6R) can be detected in the cerebrospinal fluid, conducts trans signaling by binding IL-6 and dimerized gp130, and exhibits a immune tissue expression property. IL-6R alpha, Mouse (I44-E357) is soluble form and produced in HEK293 cells with a C-Terminal His-tag.

HY-P72538

	IL-6R alpha Protein, Mouse (345a.a, HEK293, His) Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; sIL6R; CD126	Mouse	HEK293
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha, Mouse consists of 460 amino acids (M1-R460) with two fibronectin type-III-like domains contained in the N-terminal part (109-214 a.a, 215-313 a.a). Soluble IL-6R (sIL-6R) can be detected in the cerebrospinal fluid, conducts trans signaling by binding IL-6 and dimerized gp130, and exhibits a immune tissue expression property. IL-6R alpha, Mouse (L20-P364) is soluble form and produced in HEK293 cells with a C-Terminal His-tag.

HY-P75792

	*gp130/IL6ST Protein, Human (HEK293)* Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST	Human	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Human (HEK293) is a recombinant protein consisting of 596 amino acids (M23-I618) and is produced by HEK293 cells.

HY-P76371

	*gp130/IL6ST Protein, Mouse (HEK293, His)* Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130	Mouse	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Mouse (617a.a, HEK293, His) is a recombinant protein with a His label and is produced by HEK293 cells.

HY-P76374

	*gp130/IL6ST Protein, Rat (HEK293, His)* Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130	Rat	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rat (HEK293, His) is a recombinant protein with a His label that consists of 614 amino acids (M4-E618) and is produced by HEK293 cells.

HY-P75794

	*gp130/IL6ST Protein, Human (HEK293, Fc)* Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST	Human	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Human (HEK293, Fc) is a recombinant protein with a Fc label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P76375

	*gp130/IL6ST Protein, Rat (HEK293, His-Fc)* Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130	Rat	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rat (HEK293, His-Fc) is a recombinant protein with a His-Fc label that consists of 614 amino acids (M4-E618) and is produced by HEK293 cells.

HY-P701319

	*gp130/IL6ST Protein, Human (HEK293, His)* Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST	Human	HEK293
	gp130/IL6ST is an important signal transduction molecule that can form high-affinity receptor complexes for cytokines such as IL6, LIF, and OSM. Upon IL6 binding, gp130/IL6ST homodimerizes and activates the JAK-MAPK and JAK-STAT3 pathways, leading to the phosphorylation of IL6ST tyrosine residues and subsequent activation of STAT3. gp130/IL6ST Protein, Human (HEK293, His) is the recombinant human-derived gp130/IL6ST protein, expressed by HEK293 , with C-His labeled tag. The total length of gp130/IL6ST Protein, Human (HEK293, His) is 597 a.a., with molecular weight of 80-110 kDa.

HY-P75795

	*gp130/IL6ST Protein, Human (HEK293, His-Fc)* Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST	Human	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Human (HEK293, His-Fc) is a recombinant protein with a His-Fc label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P77374

	*gp130/IL6ST Protein, Rhesus Macaque (HEK293, Fc)* Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST	Rhesus Macaque	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rhesus Macaque (HEK293, Fc) is a recombinant protein with a Fc label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P77375

	*gp130/IL6ST Protein, Rhesus Macaque (HEK293, His)* Interleukin-6 receptor subunit beta; IL-6RB; CDw130; gp130; CD130; IL6ST	Rhesus Macaque	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Rhesus Macaque (HEK293, His) is a recombinant protein with a His label that consists of 618 amino acids (M1-I618) and is produced by HEK293 cells.

HY-P76370

	*gp130/IL6ST Protein, Mouse (617a.a, HEK293, Fc)* Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130	Mouse	HEK293
	Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family. gp130 inhibits the cell growth and migration, decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity. gp130/IL6ST Protein, Mouse (617a.a, HEK293, Fc) is a recombinant protein with a Fc label that consists of 617 amino acids (M1-E617) and is produced by HEK293 cells.

HY-P7377

	IL-6R alpha Protein, Human (Sf9) rHuIL-6 Receptor α; gp80; CD126	Human	Sf9 insect cells
	IL-6R alpha is a subunit alpha of IL-6 receptors, also shared by other interleukin receptors. IL-6R alpha acts as IL-6 agonist and involves in JAK/STAT, MAPK, and Akt signaling pathway. IL-6R alpha/CD126, Human consists of 468 amino acids (M1-R468) with two fibronectin type-III-like domains contained in the N-terminal part (113-217 a.a, 218-316 a.a), and a soluble form (1-365 a.a). Soluble IL-6R (sIL-6R) binds IL-6 and dimerized gp130 to achieve trans signaling, and exhibits a tissue expression property in some immune systems. IL-6R alpha Protein, Human (L20-D358) is soluble form and expressed by Sf9 insect cells with a full length of the sequence of 339 amino acids.

HY-P700249AF

	*Animal-Free IL-6* Protein, Pig (His)** Interleukin-6; Interleukin HP-1; BSF2; HSF; IFNB2	Pig	E. coli
	IL-6 protein is a multifunctional cytokine that participates in immune, regenerative and metabolic processes by binding to IL6R and forming a complex with IL6ST/gp130. This activates the IL6 signaling pathway, initiating "classical signaling" via membrane-bound IL6R and IL6ST, "trans signaling" via binding of IL6 and soluble IL6R to IL6ST, and "cluster signaling" via the IL6:IL6R complex ". Animal-Free IL-6 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-6 Protein, Pig (His) is 182 a.a., with molecular weight of ~21.9 kDa.

HY-P700216AF

	*Animal-Free IL-6* Protein, Mouse (His)** IFN-β2; B-Cell Differentiation Factor (BCDF); BSF-2; HPGF; HSF; MGI-2	Mouse	E. coli
	IL-6 protein is involved in various functions such as immunity, tissue regeneration and metabolism. Animal-Free IL-6 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-6 Protein, Mouse (His) is 187 a.a., with molecular weight of ~22.7 kDa.

HY-P72134

	CEBP delta/CEBPD Protein, Human (His-Myc) C/EBP delta; C/EBP related protein 3; CCAAT/enhancer binding protein C/EBP; delta; CCAAT/enhancer binding protein delta; CCAAT/enhancer-binding protein delta; CEBP D; CEBPD; CEBPD_HUMAN; CELF; Crp 3; Crp3; NF IL6 beta; NF-IL6-beta; Nuclear factor NF IL6 beta; Nuclear factor NF-IL6-beta	Human	E. coli
	The CEBP delta/CEBPD protein is a transcriptional activator that recognizes CCAAT and enhanced core motifs. It is critical for immune and inflammatory response genes and enhances IL6 transcription independently or together with CEBPB. CEBP delta/CEBPD Protein, Human (His-Myc) is the recombinant human-derived CEBP delta/CEBPD protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of CEBP delta/CEBPD Protein, Human (His-Myc) is 268 a.a., with molecular weight of ~43 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0141S

Estradiol-d3
Estradiol-d₃ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

HY-B0260S

Methylprednisolone-d3
Methylprednisolone-d₃ is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

HY-B0260S2

Methylprednisolone-d4
Methylprednisolone-d₄ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

HY-B0260S3

Methylprednisolone-d7
Methylprednisolone-d₇ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

HY-B0260S4

Methylprednisolone-d2
Methylprednisolone-d₂ is the deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3][4].

HY-13740S

Resiquimod-d5
Resiquimod-d₅ is deuterium labeled Resiquimod. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α[1][2].

HY-B0141S1

Estradiol-d4
Estradiol-d₄ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S3

Estradiol-d2
Estradiol-d₂ is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S2

Estradiol-d5
Estradiol-d₅ is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-128423AS

Tylvalosin-d9
Tylvalosin-d₉ (Acetylisovaleryltylo?sin-d₉)is the deuterium labeledTylvalosin(HY-128423A) . Tylvalosin is a third-generation macrolide, with anti-inflammatory property. Tylvalosin decreases the levels of IL-8, IL-6, IL-1β, PGE2, TNF-α and NO, and reduces the inflammatory cells recruitment and activation in mouse acute lung injury model .

HY-N2007S

Veratric acid-d6

Veratric acid-d₆ is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].

HY-B0667S1

Balsalazide-d4

Balsalazide-d₄ is deuterium labeled Balsalazide. Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

HY-A0031S

Bazedoxifene-d4

Bazedoxifene-d₄ is deuterium labeled Bazedoxifene. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2].

HY-A0031S2

Bazedoxifene-d4 acetate

Bazedoxifene-d₄ (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].

HY-113066S2

Guanosine 5'-diphosphate-d13 dilithium

Guanosine 5'-diphosphate-d₁₃ (GDP-d₁₃) dilithium is deuterium labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S1

Guanosine 5'-diphosphate-13C10 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀ (GDP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S

Guanosine 5'-diphosphate-15N5 dilithium

Guanosine 5'-diphosphate- ¹⁵N₅ (GDP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

HY-113066S3

Guanosine 5'-diphosphate-13C10,15N5 dilithium

Guanosine 5'-diphosphate- ¹³C₁₀, ¹⁵N₅ (GDP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled Guanosine 5'-diphosphate (HY-113066). Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K ⁺ channel. Guanosine 5'-diphosphate is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Guanosine 5'-diphosphate can be used in the research of inflammation, such as anemia of inflammation (AI).

Cat. No.	Product Name	Application	Reactivity

HY-P80189

IL-6 Antibody (YA724)	WB, IHC-P, ICC, ELISA	Human, Mouse
IL-6 Antibody (YA724) is a non-conjugated and Mouse origined monoclonal antibody about 24 kDa, targeting to IL-6. It can be used for WB,IHC-P,ICC,ELISA assays with tag free, in the background of Human, Mouse.

HY-P80723

IL-6 Antibody IL6; IFNB2; Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2	WB, IHC-P, ELISA	Human
IL-6 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 24 kDa, targeting to IL-6. It can be used for WB,IHC-P,ELISA assays with tag free, in the background of Human.

HY-P81629

IL-6R Antibody

CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ
IHC-P, IHC-F, Flow-Cyt, IF, ELISA Human, Mouse, Rat

HY-P82090

CEBPB Antibody (YA1835) CEBPB; LAP; TCF5; PP9092; CCAAT/enhancer-binding protein beta; C/EBP beta; Liver activator protein; Nuclear factor NF-IL6; Transcription factor 5; TCF-5	WB, ICC/IF, IP, FC	Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-108039

Bezisterim HE 3286; NE-3107		Alkynes
Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis . Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

IL-6

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products