1. Immunology/Inflammation GPCR/G Protein Apoptosis
  2. Interleukin Related Prostaglandin Receptor Apoptosis
  3. Pectolinarin

Pectolinarin 

Cat. No.: HY-N0314 Purity: 99.89%
COA Handling Instructions

Pectolinarin possesses anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway.

For research use only. We do not sell to patients.

Pectolinarin Chemical Structure

Pectolinarin Chemical Structure

CAS No. : 28978-02-1

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10 mg USD 80 In-stock
20 mg USD 140 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Pectolinarin possesses anti-inflammatory activity[1]. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway[2].

IC50 & Target[2]

IL-6

 

EP

 

IL-8

 

In Vitro

Pectolinarin increases Bax level, and decreases Bcl-2 level in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Pectolinarin inactivates the PI3K/Akt pathway in RA-FLSs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

622.57

Formula

C29H34O15

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)O4)O)O)O)=C(OC)C(O)=C13

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (50.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6062 mL 8.0312 mL 16.0625 mL
5 mM 0.3212 mL 1.6062 mL 3.2125 mL
10 mM 0.1606 mL 0.8031 mL 1.6062 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (3.34 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pectolinarin
Cat. No.:
HY-N0314
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