1. Immunology/Inflammation
    GPCR/G Protein
    Apoptosis
  2. Interleukin Related
    Prostaglandin Receptor
    NO Synthase
    Apoptosis
  3. Pectolinarin

Pectolinarin 

Cat. No.: HY-N0314
Handling Instructions

Pectolinarin, isolated from Cirsium chanroenicum, possesses anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway.

For research use only. We do not sell to patients.

Pectolinarin Chemical Structure

Pectolinarin Chemical Structure

CAS No. : 28978-02-1

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Description

Pectolinarin, isolated from Cirsium chanroenicum, possesses anti-inflammatory activity[1]. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway[2].

IC50 & Target[2]

IL-6

 

IL-8

 

PGE2

 

In Vitro

Pectolinarin increases Bax level, and decreases Bcl-2 level in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Pectolinarin inactivates the PI3K/Akt pathway in RA-FLSs[2].

Molecular Weight

622.57

Formula

C₂₉H₃₄O₁₅

CAS No.

28978-02-1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PectolinarinInterleukin RelatedProstaglandin ReceptorNO SynthaseApoptosisILNitric oxide synthasesNOSinflammationrheumatoidarthritisPI3KAktInhibitorinhibitorinhibit

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Pectolinarin
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HY-N0314
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