1. Immunology/Inflammation
    GPCR/G Protein
    Apoptosis
  2. Interleukin Related
    Prostaglandin Receptor
    NO Synthase
    Apoptosis
  3. Pectolinarin

Pectolinarin 

Cat. No.: HY-N0314 Purity: 99.89%
Handling Instructions

Pectolinarin, isolated from Cirsium chanroenicum, possesses anti-inflammatory activity. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway.

For research use only. We do not sell to patients.

Pectolinarin Chemical Structure

Pectolinarin Chemical Structure

CAS No. : 28978-02-1

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5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
20 mg USD 140 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Pectolinarin, isolated from Cirsium chanroenicum, possesses anti-inflammatory activity[1]. Pectolinarin inhibits secretion of IL-6 and IL-8, as well as the production of PGE2 and NO. Pectolinarin suppresses cell proliferation and inflammatory response and induces apoptosis via inactivation of the PI3K/Akt pathway[2].

IC50 & Target[2]

IL-6

 

IL-8

 

PGE2

 

In Vitro

Pectolinarin increases Bax level, and decreases Bcl-2 level in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). Pectolinarin inactivates the PI3K/Akt pathway in RA-FLSs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

622.57

Formula

C₂₉H₃₄O₁₅

CAS No.

28978-02-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (200.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6062 mL 8.0312 mL 16.0625 mL
5 mM 0.3212 mL 1.6062 mL 3.2125 mL
10 mM 0.1606 mL 0.8031 mL 1.6062 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PectolinarinInterleukin RelatedProstaglandin ReceptorNO SynthaseApoptosisILNitric oxide synthasesNOSinflammationrheumatoidarthritisPI3KAktInhibitorinhibitorinhibit

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Product Name:
Pectolinarin
Cat. No.:
HY-N0314
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