NDR
NDR kinases, NDR1/STK38 and NDR2/STK38L, sit at the intersection of the AGC family and the Hippo pathway. Each enzyme combines an N-terminal basic regulatory region, a kinase domain, and a C-terminal hydrophobic motif; binding of MOB1A/B coactivators relieves autoinhibition and permits PDK1-dependent activation-loop phosphorylation, while upstream MST1/2 kinases further stimulate the pathway. NDR1 and NDR2 control centrosome duplication and mitotic fidelity, apoptotic signaling downstream of MST kinases, and dendritic and axonal morphogenesis in neurons. Loss of NDR function is linked to chromosomal instability and tumor predisposition in mouse models, and reduced NDR2 levels occur in human cancers. Recombinant NDR proteins, often supplied with MOB1, support Hippo-pathway reconstitution, substrate-phosphorylation, and tumor-suppressor studies.
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NDR Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
