1. Apoptosis
  2. Apoptosis

Apoptosis

Apoptosis is one of the major pathways of programmed cell death.

Apoptosis or programmed cell death is a critical cellular process for the maintenance of tissue homeostasis and normal development of multicellular organisms. Inappropriate regulation of apoptosis signaling pathways may lead to several diseases including cancer. In tumor cells, the pathways that lead to apoptosis are disrupted or impaired due to which cells undergo malignant transformation.Therefore, targeting critical apoptosis regulators with a goal to induce apoptosis in cancer cells has emerged as an attractive strategy in cancer chemotherapy. DNA topoisomerase (topo) is recognized as an important target in anticancer drug discovery.

ROS production in cancer cells regulates cellular growth, cell signaling and synthesis of important substances. Furthermore, mitochondria plays an important role for the survival of cancercells, hence disrupting mitochondrial function by small molecules induces apoptosis.

Apoptosis Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin Activator >98.00%
    Cisplatin is a potent inducer of growth arrest and/or apoptosis in most cell types.
  • HY-14808
    Adarotene Activator 99.15%
    Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.
  • HY-N0848
    Epibrassinolide Activator >98.00%
    Epibrassinolide is a natural brassinosteroid (BR) derivative, is a plant regulator with a similar structure to mammalian steroids. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth.
  • HY-12040
    Elesclomol Activator 99.16%
    Elesclomol is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.
  • HY-10529
    Betulinic acid Activator 98.58%
    Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M.
  • HY-101055
    Kinetin riboside Activator
    Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.
  • HY-B2162
    Chondroitin sulfate Modulator
    Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis.
  • HY-101413
    Iberin Activator
    Iberin, a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. It inhibits cell survival with an IC50 of 2.3 μM in HL60 cell.
  • HY-18633
    Apoptosis Activator 2 Activator 98.58%
    Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.
  • HY-13915
    NSC348884 Activator 99.92%
    NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
  • HY-15359
    Episilvestrol Activator
    Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).
  • HY-15097
    Myricetin Activator
    Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.
  • HY-77293
    (E)-[6]-Dehydroparadol Activator 98.87%
    (E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.
  • HY-N0006
    Demethoxycurcumin Activator >99.0%
    Demethoxycurcumin(Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
  • HY-N0007
    Bisdemethoxycurcumin Activator 98%
    Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
  • HY-N0011
    Baohuoside I Activator 98.83%
    Baohuoside I (Icariside-II) is a component of Epimedium koreanum; a regulator of CXCR4 expression as well as function in cervical cancer and breast cancer cells; Apoptosis inducer.
  • HY-N0036
    Costunolide Activator 99.46%
    Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.
  • HY-13680
    Meisoindigo Activator
    Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
  • HY-15694
    SMIP004 Activator 98.11%
    SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, it was found to downregulate SKP2 and to stabilize p27.
  • HY-50936
    Trabectedin Activator
    Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo.