1. Apoptosis
  2. Apoptosis

Apoptosis

Apoptosis is one of the major pathways of programmed cell death.

Apoptosis or programmed cell death is a critical cellular process for the maintenance of tissue homeostasis and normal development of multicellular organisms. Inappropriate regulation of apoptosis signaling pathways may lead to several diseases including cancer. In tumor cells, the pathways that lead to apoptosis are disrupted or impaired due to which cells undergo malignant transformation.Therefore, targeting critical apoptosis regulators with a goal to induce apoptosis in cancer cells has emerged as an attractive strategy in cancer chemotherapy. DNA topoisomerase (topo) is recognized as an important target in anticancer drug discovery.

ROS production in cancer cells regulates cellular growth, cell signaling and synthesis of important substances. Furthermore, mitochondria plays an important role for the survival of cancercells, hence disrupting mitochondrial function by small molecules induces apoptosis.

Apoptosis Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin Activator >98.00%
    Cisplatin is a potent inducer of growth arrest and/or apoptosis in most cell types.
  • HY-14808
    Adarotene Activator 99.15%
    Adarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.
  • HY-N0848
    Epibrassinolide Activator >98.00%
    Epibrassinolide is a natural brassinosteroid (BR) derivative, is a plant regulator with a similar structure to mammalian steroids.
  • HY-12040
    Elesclomol Activator 99.16%
    Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.
  • HY-10529
    Betulinic acid Activator 98.58%
    Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M.
  • HY-15097
    Myricetin Activator 99.41%
    Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.
  • HY-77293
    (E)-[6]-Dehydroparadol Activator 98.87%
    (E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively.
  • HY-N0083
    Betulin Activator
    Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
  • HY-18633
    Apoptosis Activator 2 Activator 98.58%
    Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.
  • HY-13915
    NSC348884 Activator 99.92%
    NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.
  • HY-15359
    Episilvestrol Activator
    Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).
  • HY-N0006
    Demethoxycurcumin Activator
    Demethoxycurcumin(Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.
  • HY-N0007
    Bisdemethoxycurcumin Activator
    Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities.
  • HY-13680
    Meisoindigo Activator
    Meisoindigo(Natura-α; N-Methylisoindigotin; Dian III), a derivative of Indigo naturalis, might induce apoptosis and myeloid differentiation of acute myeloid leukemia (AML).
  • HY-N0036
    Costunolide Activator
    Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.
  • HY-15694
    SMIP004 Activator
    SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, it was found to downregulate SKP2 and to stabilize p27.
  • HY-N0011
    Baohuoside I Activator
    Baohuoside I (Icariside-II) is a component of Epimedium koreanum; a regulator of CXCR4 expression as well as function in cervical cancer and breast cancer cells; Apoptosis inducer.
  • HY-50936
    Trabectedin Activator
    Trabectedin (Ecteinascidin-743 or ET-743) is a novel antitumour agent of marine origin with potent antitumour activity both in vitro and in vivo.
  • HY-14615
    [6]-Gingerol Activator 98.01%
    [6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
  • HY-N2027
    Taurochenodeoxycholic acid Activator 99.80%
    Taurochenodeoxycholic acid is one of the main bioactive substances of animals' bile acid.