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Acetylcysteine (Synonyms: N-Acetyl-L-cysteine; LNAC; NAC)

Cat. No.: HY-B0215 Purity: 99.27%
Data Sheet SDS Handling Instructions

Acetylcysteine is used mainly as a mucolytic, which protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.

For research use only. We do not sell to patients.
Acetylcysteine Chemical Structure

Acetylcysteine Chemical Structure

CAS No. : 616-91-1

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    Acetylcysteine purchased from MCE. Usage Cited in: Sci Rep. 2016 Oct 27;6:35995.

    Pretreatment of NAC, a free radical scavenger, largely decreases the expression of caspase-3 and almost abolishes the H2O2 induced upregulation of PRX1. Western blot analysis shows the pretreatment of osteoblast cells with E2 partially abrogates the increased PRX1 and caspase-3 expressions induced by H2O2.

    Acetylcysteine purchased from MCE. Usage Cited in: Fundam Clin Pharmacol. 2017 Feb;31(1):64-74.

    Advanced oxidation production product (AOPP)-triggered apoptosis-related signals are triggered by ROS production. Human chondrocytes are pretreated with N-Acetylcysteine (NAC; 5 mM) for 60 min, and then, chondrocyte are co-incubated with AOPP and NAC for 24 h. (a) Pretreatment of ROS scavenger NAC markedly alleviates AOPP-triggered mitochondria-mediated apoptosis proteins. (b) Pretreatment of chondrocyte with NAC abrogates the intracellular Ca2+ mobilization. (c) NAC pretreatment atte

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    Description

    Acetylcysteine is used mainly as a mucolytic, which protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione.

    In Vitro

    N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons[2]. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells[3]. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that N-acetylcysteine interferes with redox-sensitive steps in the NGF mechanism[4].

    In Vivo

    N-acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group N-acetylcysteine 300. Lung glutathione peroxidase is significantly increases in group N-acetylcysteine 300 (P=0.04), while the other oxidation biomarkers show no significant differences[1]. N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight[5].

    Clinical Trial
    NCT Number Sponsor Condition Start Date Phase
    NCT02124525 Universidade Estadual de Londrina Tobacco Smoking|Oxidative Stress|Inflammation February 2013 Phase 3
    NCT01808521 Bloodworks (Puget Sound Blood Center)|University of Washington Purpura, Thrombotic Thrombocytopenic|TTP May 2013 Early Phase 1
    NCT00998972 Institut d'Anesthesiologie des Alpes Maritimes Brain Death|Chronic Renal Insufficiency September 2006 Phase 3
    NCT01501110 Federal University of Rio Grande do Sul|Hospital de Clinicas de Porto Alegre|Programa de pós-graduação em endocrinologia Acute Myocardial Infarction|Euthyroid Sick Syndrome|Ischemic Heart Disease November 2011 Phase 4
    NCT00532688 Bayside Health|The Alfred Heart Failure, Congestive|Kidney Failure, Chronic September 2007 Phase 2|Phase 3
    NCT00994305 University of Sao Paulo General Hospital|Fundação de Amparo à Pesquisa do Estado de São Paulo Renal Transplantation April 2005
    NCT01359722 Instituto do Coracao|Fundação de Amparo à Pesquisa do Estado de São Paulo Kidney Failure, Acute|Oxidative Stress Induction March 2010
    NCT02505477 University of California, Los Angeles Schizophrenia|Cognitive Deficits|Schizophrenia; Negative Type February 6, 2017 Phase 4
    NCT01849016 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Erasmus Medical Center|Haga Hospital|University Medical Center Groningen|ZonMw: The Netherlands Organisation for Health Research and Development|Fonds NutsOhra|Stichting Janivo|CHU Brugmann, Brussels|Erasme University Hospital|Centre Hospitalier Régional de la Citadelle|University Hospital St Luc, Brussels|Centre Hospitalier Universitaire Saint Pierre|Queen Fabiola Children's University Hospital|Guy's and St Thomas' NHS Foundation Trust Sickle Cell Disease April 2013 Phase 3
    NCT01866644 Instituto de Investigacion Sanitaria La Fe Unspecified Complication of Liver Transplant September 2011 Phase 3
    NCT03197103 Centre of Postgraduate Medical Education Breast; Deformity, Congenital|Graft Loss|Adipose Tissue Atrophy|Breast; Atrophy July 4, 2017 Phase 4
    NCT00896025 William Lee|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Texas Southwestern Medical Center Acute Liver Failure|Fulminant Hepatic Failure December 2008 Phase 4
    NCT00637624 Rijnstate Hospital Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung|Mesothelioma March 2008
    NCT02212678 University of Minnesota - Clinical and Translational Science Institute|Parkinson's Disease Society of the United Kingdom Parkinson Disease September 2014 Phase 2
    NCT00568087 Minneapolis Veterans Affairs Medical Center|Minnesota Veterans Medical Research and Education Foundation Alcoholism December 2007 Phase 1|Phase 2
    NCT00248625 University of Pittsburgh|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Acute Liver Failure|Hepatic Encephalopathy January 2000 Phase 3
    NCT01726465 Istituto Clinico Humanitas Ischemic Reperfusion Injury|Insufficiency; Hepatic, Postoperative|Liver Tumour November 2012 Phase 2
    NCT02788292 Michael Bezuhly|Nova Scotia Health Authority Adipose Tissue Atrophy|Deformity of Reconstructed Breast|Graft Loss July 2016 Phase 4
    NCT00397735 Buhimschi, Catalin S, MD|Ohio State University Labor, Premature|Preterm Premature Rupture of the Membranes|Infection|Inflammation|Chorioamnionitis October 2006 Phase 1|Phase 2
    NCT02080182 Shahid Beheshti University of Medical Sciences Pyelonephritis January 2014 Phase 2
    NCT01223326 Clinica Universidad de Navarra, Universidad de Navarra Hepatectomy|Reperfusion Injury January 2003 Phase 4
    NCT00572663 Medical University of Gdansk Chronic Kidney Disease|Proteinuria January 2005
    NCT01082445 University of Turin, Italy Foot Ulcer, Diabetic August 2009 Phase 3
    NCT00498342 University of Vermont|FlowMedic Chronic Kidney Disease June 2007
    NCT02505087 Assistance Publique - Hôpitaux de Paris Selenoprotein N-related Myopathy September 2015 Phase 2|Phase 3
    NCT01664260 Ewha Womans University Posttraumatic Stress Disorder November 2012 Phase 2
    NCT00374088 University of Michigan Transposition of Great Vessels|Congenital Heart Disease February 2005 Phase 2
    NCT00512265 University Hospital, Basel, Switzerland|Triemli Hospital Pulmonary Morbidity January 2006 Phase 4
    NCT01599884 Minnesota Veterans Medical Research and Education Foundation Chronic Obstructive Pulmonary Disease|Chronic Bronchitis June 2012
    NCT01271088 TC Erciyes University Hearing Loss, Extreme June 2010 Phase 2|Phase 3
    NCT01131468 TC Erciyes University Drug-induced Ototoxicity in Peritoneal Dialysis Patients February 2008 Phase 2
    NCT00579995 University of Nebraska Preserving Kidney Function in People Who Are at High Risk of Developing Contrast-induced Nephropathy May 2005
    NCT00751257 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Nicotine Dependence December 2006 Phase 2
    NCT00830193 St. Michael's Hospital, Toronto|Martin, Claudio M., M.D.|Fran Priestap Contrast Induced Nephropathy|Critically Ill August 2002 Phase 2|Phase 3
    NCT02723669 Arbor Pharmaceuticals, Inc. Healthy April 2014 Phase 1
    NCT01885338 VA Greater Los Angeles Healthcare System|VISN 22 Mental Illness Research, Education, and Clinical Center|American Psychiatric Foundation Schizophrenia June 2013 Phase 1
    NCT00556465 Shiraz University of Medical Sciences Diabetic Nephropathy|Chronic Kidney Disease|Diabetes Type 2 January 2007 Phase 2|Phase 3
    NCT00736866 Hospital do Coracao|Medley Pharmaceutical Industry SA Acute Kidney Failure August 2008 Phase 3
    NCT01111734 University of Minnesota - Clinical and Translational Science Institute|Minnesota Medical Foundation Deliberate Self Harm March 2011 Phase 1
    NCT00724594 Medical University of South Carolina|National Institute of Neurological Disorders and Stroke (NINDS) Chorioamnionitis|Brain Injury August 2008 Phase 1|Phase 2
    NCT02357303 Portuguese Oncology Institute, Coimbra Gastric Mucosal Lesion April 2015 Phase 4
    NCT02379637 Novartis Common Cold Associated With Cough January 2015 Phase 2
    NCT02688361 GlaxoSmithKline Infections, Respiratory Tract February 1, 2016 Phase 1
    NCT00996424 University Hospital, Ghent|BVSM Cystic Fibrosis January 2010 Phase 4
    NCT02686385 Institute of Liver and Biliary Sciences, India Drug Induced Liver Injury February 2016
    NCT03164421 Zagazig University PCOS January 2017 Phase 2
    NCT00870883 Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude|Conselho Nacional de Desenvolvimento Científico e Tecnológico Hypotension|Acute Renal Failure March 2009 Phase 2
    NCT03121222 Aristotle University Of Thessaloniki|National and Kapodistrian University of Athens|European University Cyprus Glutathione Metabolism Anemias November 1, 2015 Phase 2
    NCT00542750 Medical University of South Carolina|National Institute on Drug Abuse (NIDA)|American Academy of Child Adolescent Psychiatry. Cannabis Dependence January 2008 Phase 1|Phase 2
    NCT00136825 National Institute on Drug Abuse (NIDA) Cocaine-Related Disorders March 2003 Phase 1
    NCT01739790 University of Minnesota - Clinical and Translational Science Institute COPD|Chronic Bronchitis January 2013
    NCT01232790 Yale University|National Alliance for Research on Schizophrenia and Depression Schizophrenia February 2010
    NCT00993265 Yale University|Trichotillomania Learning Center Trichotillomania|Hair Pulling October 2009 Phase 2
    NCT01210456 Tokushukai Medical Group Chronic Kidney Disease October 2009 Phase 3
    NCT01278784 Medical University of Vienna Dry Eye Syndromes March 2011 Phase 1
    NCT02579772 Queen's University Pulmonary Disease, Chronic Obstructive July 2015 Phase 4
    NCT02483130 King's College London Psychosis June 2015
    NCT01470027 Weill Medical College of Cornell University|National Institute on Aging (NIA) Parkinson Disease January 2012 Phase 1|Phase 2
    NCT01427517 University of Minnesota - Clinical and Translational Science Institute|Rare Diseases Clinical Research Network|National Center for Advancing Translational Science (NCATS)|National Institute of Neurological Disorders and Stroke (NINDS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Parkinson's Disease|Gaucher's Disease July 2011 Phase 1
    NCT00506506 Lawson Health Research Institute|The Physicians' Services Incorporated Foundation Chronic Kidney Disease October 2007 Phase 3
    NCT02088216 Qilu Hospital of Shandong University Non-Cystic Fibrosis Bronchiectasis March 2014 Phase 4
    NCT00539513 Yale University Obsessive-Compulsive Disorder June 2006 Phase 2
    NCT00962442 Erasme University Hospital Alcoholic Hepatitis September 2000 Phase 3
    NCT01138956 Hospital Universitário Professor Edgard Santos Visceral Leishmaniasis|Immune Response|Treatment April 2010
    NCT00122018 Linda F. Barr, M.D.|Abbott|Pulmonary Critical Care Associates of Baltimore Kidney Failure, Acute|Kidney Failure, Chronic|Cardiac Surgical Procedures May 2002 Phase 2
    NCT01033149 Lindner Center of HOPE|University of Cincinnati Bulimia Nervosa December 2009 Phase 3
    NCT02241876 University of Campinas, Brazil Head and Neck Neoplasms October 2014 Phase 4
    NCT00558142 University of Edinburgh|NHS Lothian Radiocontrast-induced Nephropathy February 2008 Phase 4
    NCT01962961 Indiana University|BioAdvantex Pharma HIV|Endothelial Dysfunction|Oxidative Stress October 2013 Phase 1|Phase 2
    NCT00453180 Indiana University School of Medicine|National Alliance for Autism Research|Indiana University Autistic Disorder|Asperger Syndrome|Child Development Disorders, Pervasive March 2007 Phase 2
    NCT01704482 Assiut University Cardiac Surgery for Rheumatic Valvular Heart Disease|Renal Dysfunction February 2011 Phase 2
    NCT02569957 Sidney Kimmel Cancer Center at Thomas Jefferson University|National Institutes of Health (NIH)|Thomas Jefferson University Malignant Ovarian Endometrioid Tumor|Malignant Ovarian Serous Tumor|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma October 2, 2015 Phase 2
    NCT01394419 Yonsei University Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft September 2010 Phase 4
    NCT01232257 A.C. Abrahams|UMC Utrecht Chronic Kidney Disease|Chronic Kidney Failure|End Stage Kidney Disease|End Stage Renal Disease July 2011 Phase 3
    NCT00211653 Minneapolis Veterans Affairs Medical Center Kidney Failure April 2003 Phase 1|Phase 2
    NCT03008889 Emory University Autism Spectrum Disorder August 2017 Phase 2
    NCT01354132 Beth Israel Deaconess Medical Center|Center de Neurosciences Psychiatrique, Lausanne, Switzerland Schizophrenic Psychoses May 2011 Phase 2
    NCT00440869 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) End-Stage Renal Disease|Dialysis|Hemodialysis March 2007 Phase 1
    NCT00736541 University of Pittsburgh End Stage Liver Failure July 2004
    NCT02972398 Tianjin Anding Hospital Major Depressive Disorders September 2015
    NCT01172275 Yale University Obsessive-Compulsive Disorder July 2012 Phase 2
    NCT01675661 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Cannabis Dependence January 2014 Phase 3
    NCT02015403 Institute of Liver and Biliary Sciences, India Ischemic Hepatitis December 2013
    NCT00568113 Assiut University Preterm Labour July 2007 Phase 4
    NCT01653171 Pontificia Universidad Catolica de Chile Stomach Neoplasms July 2012 Phase 4
    NCT01612221 University of Utah Patients at Risk for Melanoma September 2012 Phase 2
    NCT00188630 University Health Network, Toronto|Heart and Stroke Foundation of Ontario Heart Disease|Acute Renal Failure July 2003 Phase 3
    NCT02737358 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Nicotine Dependence August 2016 Phase 2
    NCT00808795 Tehran University of Medical Sciences Radiocontrast-Induced Nephropathy|Chronic Kidney Disease|Diabetes Mellitus April 2006 Phase 3
    NCT00391911 Royal Alexandra Hospital|University of Alberta|Gambro Renal Products, Inc. Rhabdomyolysis November 2006 Phase 2
    NCT00809094 Stanford University|Cystic Fibrosis Foundation Therapeutics Cystic Fibrosis November 2008 Phase 2
    NCT02123511 Mayo Clinic|National Cancer Institute (NCI) Mucositis|Oral Complications|Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Basal Cell Carcinoma of the Lip|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Lymphoepithelioma of the Oropharynx|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma April 2014
    NCT00575419 Oregon Health and Science University Contrast Induced Nephropathy November 2007 Phase 1
    NCT00190034 Far Eastern Memorial Hospital|Synmosa Biopharma Corp. Cardiovascular Disease|Renal Insufficiency, Acute|Cardiopulmonary Bypass January 2005 Phase 4
    NCT00421785 Assaf-Harofeh Medical Center ESRD|Peritoneal Dialysis February 2007
    NCT01214083 VA Office of Research and Development Alcoholism October 2010 Phase 2
    NCT01394510 Utzschneider, Kristina, M.D.|VA Puget Sound Health Care System Type 2 Diabetes|Oxidative Stress June 2011
    NCT02249546 National Taiwan University Hospital Helicobacter Pylori Infection September 2014 Phase 4
    NCT01878695 Thomas Jefferson University Stage 0/1 Breast Cancer|Post Biopsy|Pre-surgery July 2012 Phase 1
    NCT00218491 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Cocaine Dependence November 2005 Phase 2
    NCT00497328 National University Hospital, Singapore Contrast Induced Nephropathy August 2007 Phase 2|Phase 3
    NCT01050270 University of Edinburgh|NHS Lothian|Chief Scientist Office of the Scottish Government Overdose September 2010 Phase 4
    NCT00187330 Sunnybrook Health Sciences Centre|The Physicians' Services Incorporated Foundation Heart Disease|Renal Insufficiency March 2004 Phase 2
    NCT02265224 Zambon SpA the Study Has Been Performed in Healthy Subjects September 2014 Phase 1
    NCT00203099 Teva Pharmaceutical Industries Relapse Remitting Multiple Sclerosis December 2004 Phase 2
    NCT02088502 Isfahan University of Medical Sciences Contrast-Induced Nephropathy September 2013 Phase 2|Phase 3
    NCT00483314 McGill University Health Center|March of Dimes Homocystinuria November 2007 Phase 2
    NCT01555970 University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo Obsessive-Compulsive Disorder March 2012 Phase 2
    NCT01172288 Yale University|American Academy of Child Adolescent Psychiatry. Tourettes Syndrome|Tic July 2010 Phase 2
    NCT01131572 Lindner Center of HOPE NAC February 2010 Phase 2|Phase 3
    NCT03018236 Hospital de Clinicas de Porto Alegre|Secretaria Nacional de Políticas sobre Drogas (SENAD) Cocaine Addiction|Alcohol Addiction January 2017 Phase 4
    NCT00569465 University of Turin, Italy Type 2 Diabetes Mellitus|Hypertension January 2005 Phase 4
    NCT02335060 Yale University Healthy March 2014 Phase 1
    NCT02094625 Children's Hospital Los Angeles Neuroectodermal Tumors, Primitive|Liver Neoplasms|Neoplasms, Germ Cell and Embryonal|Osteosarcoma|Other Childhood Cancers Using Cisplatin-based Regimens March 2016 Phase 1
    NCT01800526 Bloodworks (Puget Sound Blood Center)|University of Washington Sickle Cell Disease|Sickle Cell Anemia March 2013 Phase 1|Phase 2
    NCT01021163 Yonsei University Coronary Artery Occlusion Phase 4
    NCT00332631 Austin Health Cardiac Surgery and Cardiopulmonary Bypass August 2004 Phase 2
    NCT00611897 Yale University Cognitive Dysfunction January 2006 Phase 1|Phase 2
    NCT01005810 Medical University of South Carolina Cannabis Dependence September 2009 Phase 2
    NCT02141620 University of Kentucky|National Institute on Drug Abuse (NIDA) Cocaine Abuse|Cocaine Dependence May 2014 Early Phase 1
    NCT02707640 Hoffmann-La Roche Idiopathic Pulmonary Fibrosis August 2013 Phase 2
    NCT02994875 Yale University Cocaine Dependence May 2016 Early Phase 1
    NCT00493727 VA Office of Research and Development|West Virginia University Diabetes|Proteinuria September 2006
    NCT00539188 Yale University Borderline Personality Disorder|Self-Injurious Behavior September 2007 Phase 2
    NCT00396396 Eastern Virginia Medical School Creatinine Clearance October 2006
    NCT00915200 The University of Texas Health Science Center at San Antonio|National Center for Complementary and Integrative Health (NCCIH)|VA Office of Research and Development Diabetic Nephropathies|Proteinuria|Oxidative Stress October 2009 Phase 2
    NCT01015209 Medical University of Vienna Dry Eye Syndromes September 2010 Phase 1
    NCT00564642 National Research Institute of Tuberculosis and Lung Disease, Iran Hepatitis|Tuberculosis November 2007
    NCT01251029 Assaf-Harofeh Medical Center Chronic Kidney Diseases|General Anesthesia January 2011 Phase 1
    NCT01747616 Medical University of Vienna|Croma-Pharma GmbH Dry Eye Syndrome July 2011 Phase 1
    NCT01384591 The University of Texas Medical Branch, Galveston|Lantheus Medical Imaging|National Institutes of Health (NIH) Aging July 2011 Phase 1|Phase 2
    NCT02791945 University of California, San Francisco|United States Department of Defense|Northern California Institute of Research and Education|San Francisco Veterans Affairs Medical Center|Institute for Translational Neuroscience Traumatic Brain Injury (TBI)|Hazardous and Harmful Alcohol Use August 2016 Phase 2
    NCT02357290 Massachusetts General Hospital Bipolar Disorder January 2014 Phase 4
    NCT00428883 Università Politecnica delle Marche Scleroderma, Diffuse January 2007 Phase 2|Phase 3
    NCT00492518 Technische Universität München Contrast Induced Nephropathy|Kidney Diseases|Renal Failure|Adverse Effects February 2002 Phase 4
    NCT02719392 Massachusetts General Hospital Bipolar Disorder|Bipolar Depression September 2016 Phase 4
    NCT02750319 Memorial Sloan Kettering Cancer Center|Washington University School of Medicine|The Cleveland Clinic|Vanderbilt University School of Medicine Thoracic Surgery|Atrial Fibrillation in High Risk Patients April 2016 Phase 3
    NCT01017796 University of Thessaly Contrast Induced Nephropathy January 2009 Early Phase 1
    NCT01550432 Stanford University|National Center for Complementary and Integrative Health (NCCIH) Obesity|Hyperlipidemia|Insulin Resistance|Hypertension June 2011
    NCT00493610 VA Office of Research and Development|West Virginia University Hepatitis C November 2006
    NCT00969904 University Hospital, Antwerp COPD March 2009 Phase 4
    NCT01537926 The University of Texas Health Science Center, Houston|National Institutes of Health (NIH) Hypertrophic Cardiomyopathy January 2012 Phase 1
    NCT00775476 State University of New York - Upstate Medical University Systemic Lupus Erythematosus March 2009 Phase 1|Phase 2
    NCT00238173 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Bone Marrow Suppression|Brain and Central Nervous System Tumors|Drug/Agent Toxicity by Tissue/Organ|Long-term Effects Secondary to Cancer Therapy in Children December 2004 Phase 1
    NCT00650091 Duke University|National Heart, Lung, and Blood Institute (NHLBI) Pulmonary Fibrosis October 2009 Phase 3
    NCT00614757 Midwest Biomedical Research Foundation Insulin Resistance|Metabolic Syndrome x May 2005
    NCT00353340 Shaare Zedek Medical Center Acute Renal Failure Contrast Nephropathy January 2005
    NCT01424033 University of Michigan Interstitial Lung Disease|Connective Tissue Disease December 2011 Phase 2|Phase 3
    NCT03221231 Universitair Ziekenhuis Brussel Cannabis Use Disorder|Cannabis Dependence May 15, 2016 Phase 4
    NCT03104725 National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Parkinson Disease July 28, 2017
    NCT02182167 University of Cape Town|Medical Research Council, South Africa Drug-Induced Liver Injury May 2014 Phase 2|Phase 3
    NCT02499029 Medical University of South Carolina PTSD|Addiction February 2013 Phase 2
    NCT01111422 Ewha Womans University End-Stage Kidney Disease|Peritoneal Dialysis March 2010 Phase 4
    NCT02760901 Ain Shams University Cisplatin Nephrotoxicity November 2013 Phase 2
    NCT00247507 Far Eastern Memorial Hospital Anemia|Atherosclerosis|End-Stage Renal Disease|Oxidative Stress|Pro-Inflammation September 2005 Phase 4
    NCT00267384 Soroka University Medical Center Drug Induced Nephrotoxicity March 2006 Phase 2|Phase 3
    NCT00639496 Zambon SpA Pulmonary Fibrosis March 2000 Phase 3
    NCT03149107 University Hospital, Bonn|University of Cologne|Central Institute of Mental Health, Mannheim|Ludwig-Maximilians - University of Munich|University Hospital Tuebingen|Heinrich-Heine University, Duesseldorf|Charite University, Berlin, Germany|RWTH Aachen University Subjects Presenting Ultra-high Risk (UHR) for Psychosis September 2016 Phase 3
    NCT00004467 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Texas Acute Liver Failure June 1998 Phase 3
    NCT00851708 University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo Deceased Kidney Transplantation
    NCT00196885 German Cancer Research Center|Heidelberg University Gastrointestinal Neoplasms|Bronchial Carcinoma|Hodgkin Disease|Non-Hodgkin Lymphoma|Weight Loss December 2003 Phase 2
    NCT02966873 Medical University of South Carolina|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health (NIH) Post Traumatic Stress Disorder (PTSD)|Addiction|Alcohol Abuse October 2016 Phase 2
    NCT00525551 Karolinska University Hospital|Karolinska Institutet|AstraZeneca Otosclerosis September 2007 Phase 4
    NCT01063205 Baylor College of Medicine|National Institute on Drug Abuse (NIDA) Methamphetamine Abuse|Methamphetamine Dependence|Substance Abuse March 2010 Phase 1
    NCT01265563 VA Office of Research and Development|National Center for Complementary and Integrative Health (NCCIH) Diabetic Nephropathy|Proteinuria|Oxidative Stress January 2011 Phase 2
    NCT01907061 Baylor Research Institute Acute Renal Failure July 2007
    NCT00237614 University of Milan Contrast-Induced Nephropathy|Acute Myocardial Infarction February 2003 Phase 2|Phase 3
    NCT01778309 Democritus University of Thrace Skeletal Muscle Damage|Skeletal Muscle Performance|Intgracellular Signaling in Skeletal Muscle|Inflammatory Status January 2010
    NCT02159196 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|ZonMw: The Netherlands Organisation for Health Research and Development Respiratory Failure July 2014
    NCT01037465 Boston University Cardiovascular Disease September 2008
    NCT02761577 Clinical Hospital Centre Zagreb Kidney Diseases|Contrast Media Reaction June 2012 Phase 4
    NCT01993849 Kevin Gray|Medical University of South Carolina Onychophagia October 2013 Phase 3
    NCT00399256 Robert Bosch Gesellschaft für Medizinische Forschung mbH Chronic Kidney Failure March 2004
    NCT01138137 OHSU Knight Cancer Institute Ovarian Carcinoma, Stage 3 or 4|Epithelial Ovarian Carcinoma|Primary Peritoneal Carcinoma June 2010 Phase 1
    NCT01187108 University of Colorado, Denver|Universidad Peruana Cayetano Heredia|Jackson, Brian, M.S.|Thomas H Maren Foundation Erythrocytosis|Mountain Sickness June 2013 Phase 1|Phase 2
    NCT00184977 Radboud University|Dutch Health Care Insurance Board (CVZ)|GlaxoSmithKline|Zambon SpA|The Netherlands Asthma Foundation Pulmonary Disease, Chronic Obstructive|Lung Diseases, Obstructive|Bronchitis, Chronic December 1998 Phase 4
    NCT02971306 Postgraduate Institute of Medical Education and Research Alcoholic Hepatitis July 2014 Phase 4
    NCT00507052 Assaf-Harofeh Medical Center Hemodialysis|Renal Failure
    NCT01753752 Gerhard Garhofer|Croma-Pharma GmbH|Medical University of Vienna Dry Eye Syndrome September 2012 Phase 2
    NCT01905696 Duke University Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation March 2013 Early Phase 1
    NCT01495260 Onofre, Aurora Pujol, M.D.|Ministerio de Sanidad, Servicios Sociales e Igualdad|Fundacion Hesperia Adrenomyeloneuropathy September 2011 Phase 2
    NCT02723162 Medical University of South Carolina Nicotine Dependence, Cigarettes January 2016
    NCT01891292 The University of The West Indies|Caribbean Health Research Council Microalbuminuria|Sickle Cell Nephropathy July 2013
    NCT00188773 University Health Network, Toronto Insulin Resistance Syndrome X|Pancreatic Beta Cell Function January 2004 Phase 4
    NCT02930031 National and Kapodistrian University of Athens Skeletal Muscle Damage|Aseptic Inflammation|Skeletal Muscle Function January 2015
    NCT02583672 University of Minnesota - Clinical and Translational Science Institute|Rare Diseases Clinical Research Network|National Center for Advancing Translational Science (NCATS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institute of Neurological Disorders and Stroke (NINDS)|Lysosomal Disease Network Gaucher Disease Type 1 September 2015 Phase 2
    NCT02348762 Baylor College of Medicine Aging|Erythrocyte Glutathione Deficiency|Muscle Weakness November 2014 Phase 1
    NCT02348775 Baylor College of Medicine HIV Infection|Erythrocyte Glutathione Deficiency November 2014 Phase 1
    NCT01386645 Seattle Institute for Biomedical and Clinical Research|VA Puget Sound Health Care System Impaired Glucose Tolerance|Oxidative Stress|Prediabetes|Impaired Fasting Glucose July 2011
    NCT00655928 Imperial College London|Royal College of Physicians|Royal Brompton & Harefield NHS Foundation Trust Acute Lung Injury August 2007 Phase 2
    NCT02818270 Chang Gung University|Chang Gung Memorial Hospital Chronic Obstructive Pulmonary Disease June 2016
    NCT00716001 Osaka General Medical Center Chronic Renal Failure July 2008 Phase 4
    NCT02206178 University Hospital, Clermont-Ferrand|Gisèle PICKERING, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital|Christian DUALE, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital|Gilles DUCHEIX, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital Healthy September 2013 Phase 1
    NCT00463671 Assaf-Harofeh Medical Center Diabetic Foot Ulcers December 2003
    NCT02362425 National Institute of Nursing Research (NINR)|National Institutes of Health Clinical Center (CC) Neuromuscular Disease January 21, 2015 Phase 1|Phase 2
    NCT00585559 Vanderbilt University|National Institutes of Health (NIH)|National Institute of General Medical Sciences (NIGMS)|Vanderbilt University Medical Center Aneurysmal Subarachnoid Hemorrhage|Cerebral Vasospasm April 2007
    NCT01355198 Baylor College of Medicine HIV Infection|Erythrocyte Glutathione Deficiency August 2010 Phase 1
    NCT02911285 Medical University of South Carolina|United States Department of Defense|Institute for Translational Neuroscience Posttraumatic Stress Disorder (PTSD)|Alcohol Use Disorder (AUD) October 2016 Phase 2
    NCT00467831 National Human Genome Research Institute (NHGRI)|National Institutes of Health Clinical Center (CC) Hermansky-Pudlak Syndrome (HPS)|Pulmonary Fibrosis|Oculocutaneous Albinism|Platelet Storage Pool Deficiency|Metabolic Disease April 2007 Phase 1|Phase 2
    NCT01699204 University of British Columbia Asthma September 2007
    NCT00552786 National Taiwan University Hospital|Institute of Occupational Safety and Health, Taiwan|Municipal Hospital of Tainan, Taiwan Hearing Loss November 2007 Phase 2
    NCT01564303 The Nazareth Hospital|Western Galilee Hospital-Nahariya|The Nazareth Hospital, Israel Contrast Media Induced Nephropathy May 2012
    NCT03220776 Medical University of South Carolina|National Institutes of Health (NIH)|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Alcohol Use Disorder|Bipolar Disorder August 1, 2017 Phase 2
    NCT01597765 Mahidol University|ChaingMai University Thalassemia June 2009
    NCT01467466 VA Office of Research and Development|The George Institute Acute Renal Failure|Kidney Disease|Coronary Artery Disease February 7, 2013 Phase 3
    NCT02294591 Region Syddanmark Bipolar Disorder November 2014 Phase 2
    NCT02168387 Duke University Atelectasis December 2010 Phase 4
    NCT02476526 VA Greater Los Angeles Healthcare System|General Electric Chronic Kidney Disease|Pulmonary Embolism|Renal Artery Stenosis|Pulmonary Cancer September 2008 Phase 4
    NCT00434005 University of Washington|National Institutes of Health (NIH) Healthy July 2008
    NCT02040818 University of California, San Diego|National Institutes of Health (NIH) Hemodialysis Catheter-related Bacteremia November 2013 Phase 2|Phase 3
    NCT00592618 Assaf-Harofeh Medical Center ESRD|Sleep Apnea
    NCT02269540 Centre for Addiction and Mental Health Major Depressive Disorder October 2014 Early Phase 1
    NCT01870193 Rajagopal V Sekhar|National Institute on Aging (NIA)|Baylor College of Medicine Aging October 2012
    NCT02882477 Hadassah Medical Organization Diabetes Mellitus|Iron Metabolism Disorders|Gastroduodenal Ulcer|Optic Atrophy|Sensorineural Hearing Loss|Platelet Dysfunction December 2016 Phase 2|Phase 3
    NCT01188005 University of Athens Obstructive Sleep Apnea Syndrome August 2010
    NCT00003346 Memorial Sloan Kettering Cancer Center|National Cancer Institute (NCI) Melanoma (Skin) November 1997 Phase 2
    NCT01160627 Odense University Hospital Contrast Induced Nephropathy April 2010
    NCT01381354 University of Iowa|Direct MS Canada|DJO Incorporated|Pinnaclife Inc.|TZ Press, LLC Multiple Sclerosis October 2010 Phase 1
    NCT02124525 Universidade Estadual de Londrina Tobacco Smoking|Oxidative Stress|Inflammation February 2013 Phase 3
    NCT01808521 Bloodworks (Puget Sound Blood Center)|University of Washington Purpura, Thrombotic Thrombocytopenic|TTP May 2013 Early Phase 1
    NCT00998972 Institut d'Anesthesiologie des Alpes Maritimes Brain Death|Chronic Renal Insufficiency September 2006 Phase 3
    NCT01501110 Federal University of Rio Grande do Sul|Hospital de Clinicas de Porto Alegre|Programa de pós-graduação em endocrinologia Acute Myocardial Infarction|Euthyroid Sick Syndrome|Ischemic Heart Disease November 2011 Phase 4
    NCT00532688 Bayside Health|The Alfred Heart Failure, Congestive|Kidney Failure, Chronic September 2007 Phase 2|Phase 3
    NCT00994305 University of Sao Paulo General Hospital|Fundação de Amparo à Pesquisa do Estado de São Paulo Renal Transplantation April 2005
    NCT01359722 Instituto do Coracao|Fundação de Amparo à Pesquisa do Estado de São Paulo Kidney Failure, Acute|Oxidative Stress Induction March 2010
    NCT02505477 University of California, Los Angeles Schizophrenia|Cognitive Deficits|Schizophrenia; Negative Type February 6, 2017 Phase 4
    NCT01849016 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Erasmus Medical Center|Haga Hospital|University Medical Center Groningen|ZonMw: The Netherlands Organisation for Health Research and Development|Fonds NutsOhra|Stichting Janivo|CHU Brugmann, Brussels|Erasme University Hospital|Centre Hospitalier Régional de la Citadelle|University Hospital St Luc, Brussels|Centre Hospitalier Universitaire Saint Pierre|Queen Fabiola Children's University Hospital|Guy's and St Thomas' NHS Foundation Trust Sickle Cell Disease April 2013 Phase 3
    NCT01866644 Instituto de Investigacion Sanitaria La Fe Unspecified Complication of Liver Transplant September 2011 Phase 3
    NCT03197103 Centre of Postgraduate Medical Education Breast; Deformity, Congenital|Graft Loss|Adipose Tissue Atrophy|Breast; Atrophy July 4, 2017 Phase 4
    NCT00896025 William Lee|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Texas Southwestern Medical Center Acute Liver Failure|Fulminant Hepatic Failure December 2008 Phase 4
    NCT00637624 Rijnstate Hospital Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung|Mesothelioma March 2008
    NCT02212678 University of Minnesota - Clinical and Translational Science Institute|Parkinson's Disease Society of the United Kingdom Parkinson Disease September 2014 Phase 2
    NCT00568087 Minneapolis Veterans Affairs Medical Center|Minnesota Veterans Medical Research and Education Foundation Alcoholism December 2007 Phase 1|Phase 2
    NCT00248625 University of Pittsburgh|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Acute Liver Failure|Hepatic Encephalopathy January 2000 Phase 3
    NCT01726465 Istituto Clinico Humanitas Ischemic Reperfusion Injury|Insufficiency; Hepatic, Postoperative|Liver Tumour November 2012 Phase 2
    NCT02788292 Michael Bezuhly|Nova Scotia Health Authority Adipose Tissue Atrophy|Deformity of Reconstructed Breast|Graft Loss July 2016 Phase 4
    NCT00397735 Buhimschi, Catalin S, MD|Ohio State University Labor, Premature|Preterm Premature Rupture of the Membranes|Infection|Inflammation|Chorioamnionitis October 2006 Phase 1|Phase 2
    NCT02080182 Shahid Beheshti University of Medical Sciences Pyelonephritis January 2014 Phase 2
    NCT01223326 Clinica Universidad de Navarra, Universidad de Navarra Hepatectomy|Reperfusion Injury January 2003 Phase 4
    NCT00572663 Medical University of Gdansk Chronic Kidney Disease|Proteinuria January 2005
    NCT01082445 University of Turin, Italy Foot Ulcer, Diabetic August 2009 Phase 3
    NCT00498342 University of Vermont|FlowMedic Chronic Kidney Disease June 2007
    NCT02505087 Assistance Publique - Hôpitaux de Paris Selenoprotein N-related Myopathy September 2015 Phase 2|Phase 3
    NCT01664260 Ewha Womans University Posttraumatic Stress Disorder November 2012 Phase 2
    NCT00374088 University of Michigan Transposition of Great Vessels|Congenital Heart Disease February 2005 Phase 2
    NCT00512265 University Hospital, Basel, Switzerland|Triemli Hospital Pulmonary Morbidity January 2006 Phase 4
    NCT01599884 Minnesota Veterans Medical Research and Education Foundation Chronic Obstructive Pulmonary Disease|Chronic Bronchitis June 2012
    NCT01271088 TC Erciyes University Hearing Loss, Extreme June 2010 Phase 2|Phase 3
    NCT01131468 TC Erciyes University Drug-induced Ototoxicity in Peritoneal Dialysis Patients February 2008 Phase 2
    NCT00579995 University of Nebraska Preserving Kidney Function in People Who Are at High Risk of Developing Contrast-induced Nephropathy May 2005
    NCT00751257 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Nicotine Dependence December 2006 Phase 2
    NCT00830193 St. Michael's Hospital, Toronto|Martin, Claudio M., M.D.|Fran Priestap Contrast Induced Nephropathy|Critically Ill August 2002 Phase 2|Phase 3
    NCT02723669 Arbor Pharmaceuticals, Inc. Healthy April 2014 Phase 1
    NCT01885338 VA Greater Los Angeles Healthcare System|VISN 22 Mental Illness Research, Education, and Clinical Center|American Psychiatric Foundation Schizophrenia June 2013 Phase 1
    NCT00556465 Shiraz University of Medical Sciences Diabetic Nephropathy|Chronic Kidney Disease|Diabetes Type 2 January 2007 Phase 2|Phase 3
    NCT00736866 Hospital do Coracao|Medley Pharmaceutical Industry SA Acute Kidney Failure August 2008 Phase 3
    NCT01111734 University of Minnesota - Clinical and Translational Science Institute|Minnesota Medical Foundation Deliberate Self Harm March 2011 Phase 1
    NCT00724594 Medical University of South Carolina|National Institute of Neurological Disorders and Stroke (NINDS) Chorioamnionitis|Brain Injury August 2008 Phase 1|Phase 2
    NCT02357303 Portuguese Oncology Institute, Coimbra Gastric Mucosal Lesion April 2015 Phase 4
    NCT02379637 Novartis Common Cold Associated With Cough January 2015 Phase 2
    NCT02688361 GlaxoSmithKline Infections, Respiratory Tract February 1, 2016 Phase 1
    NCT00996424 University Hospital, Ghent|BVSM Cystic Fibrosis January 2010 Phase 4
    NCT02686385 Institute of Liver and Biliary Sciences, India Drug Induced Liver Injury February 2016
    NCT03164421 Zagazig University PCOS January 2017 Phase 2
    NCT00870883 Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude|Conselho Nacional de Desenvolvimento Científico e Tecnológico Hypotension|Acute Renal Failure March 2009 Phase 2
    NCT03121222 Aristotle University Of Thessaloniki|National and Kapodistrian University of Athens|European University Cyprus Glutathione Metabolism Anemias November 1, 2015 Phase 2
    NCT00542750 Medical University of South Carolina|National Institute on Drug Abuse (NIDA)|American Academy of Child Adolescent Psychiatry. Cannabis Dependence January 2008 Phase 1|Phase 2
    NCT00136825 National Institute on Drug Abuse (NIDA) Cocaine-Related Disorders March 2003 Phase 1
    NCT01739790 University of Minnesota - Clinical and Translational Science Institute COPD|Chronic Bronchitis January 2013
    NCT01232790 Yale University|National Alliance for Research on Schizophrenia and Depression Schizophrenia February 2010
    NCT00993265 Yale University|Trichotillomania Learning Center Trichotillomania|Hair Pulling October 2009 Phase 2
    NCT01210456 Tokushukai Medical Group Chronic Kidney Disease October 2009 Phase 3
    NCT01278784 Medical University of Vienna Dry Eye Syndromes March 2011 Phase 1
    NCT02579772 Queen's University Pulmonary Disease, Chronic Obstructive July 2015 Phase 4
    NCT02483130 King's College London Psychosis June 2015
    NCT01470027 Weill Medical College of Cornell University|National Institute on Aging (NIA) Parkinson Disease January 2012 Phase 1|Phase 2
    NCT01427517 University of Minnesota - Clinical and Translational Science Institute|Rare Diseases Clinical Research Network|National Center for Advancing Translational Science (NCATS)|National Institute of Neurological Disorders and Stroke (NINDS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Parkinson's Disease|Gaucher's Disease July 2011 Phase 1
    NCT00506506 Lawson Health Research Institute|The Physicians' Services Incorporated Foundation Chronic Kidney Disease October 2007 Phase 3
    NCT02088216 Qilu Hospital of Shandong University Non-Cystic Fibrosis Bronchiectasis March 2014 Phase 4
    NCT00539513 Yale University Obsessive-Compulsive Disorder June 2006 Phase 2
    NCT00962442 Erasme University Hospital Alcoholic Hepatitis September 2000 Phase 3
    NCT01138956 Hospital Universitário Professor Edgard Santos Visceral Leishmaniasis|Immune Response|Treatment April 2010
    NCT00122018 Linda F. Barr, M.D.|Abbott|Pulmonary Critical Care Associates of Baltimore Kidney Failure, Acute|Kidney Failure, Chronic|Cardiac Surgical Procedures May 2002 Phase 2
    NCT01033149 Lindner Center of HOPE|University of Cincinnati Bulimia Nervosa December 2009 Phase 3
    NCT02241876 University of Campinas, Brazil Head and Neck Neoplasms October 2014 Phase 4
    NCT00558142 University of Edinburgh|NHS Lothian Radiocontrast-induced Nephropathy February 2008 Phase 4
    NCT01962961 Indiana University|BioAdvantex Pharma HIV|Endothelial Dysfunction|Oxidative Stress October 2013 Phase 1|Phase 2
    NCT00453180 Indiana University School of Medicine|National Alliance for Autism Research|Indiana University Autistic Disorder|Asperger Syndrome|Child Development Disorders, Pervasive March 2007 Phase 2
    NCT01704482 Assiut University Cardiac Surgery for Rheumatic Valvular Heart Disease|Renal Dysfunction February 2011 Phase 2
    NCT02569957 Sidney Kimmel Cancer Center at Thomas Jefferson University|National Institutes of Health (NIH)|Thomas Jefferson University Malignant Ovarian Endometrioid Tumor|Malignant Ovarian Serous Tumor|Recurrent Fallopian Tube Carcinoma|Recurrent Ovarian Carcinoma|Recurrent Primary Peritoneal Carcinoma October 2, 2015 Phase 2
    NCT01394419 Yonsei University Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft September 2010 Phase 4
    NCT01232257 A.C. Abrahams|UMC Utrecht Chronic Kidney Disease|Chronic Kidney Failure|End Stage Kidney Disease|End Stage Renal Disease July 2011 Phase 3
    NCT00211653 Minneapolis Veterans Affairs Medical Center Kidney Failure April 2003 Phase 1|Phase 2
    NCT03008889 Emory University Autism Spectrum Disorder August 2017 Phase 2
    NCT01354132 Beth Israel Deaconess Medical Center|Center de Neurosciences Psychiatrique, Lausanne, Switzerland Schizophrenic Psychoses May 2011 Phase 2
    NCT00440869 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) End-Stage Renal Disease|Dialysis|Hemodialysis March 2007 Phase 1
    NCT00736541 University of Pittsburgh End Stage Liver Failure July 2004
    NCT02972398 Tianjin Anding Hospital Major Depressive Disorders September 2015
    NCT01172275 Yale University Obsessive-Compulsive Disorder July 2012 Phase 2
    NCT01675661 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Cannabis Dependence January 2014 Phase 3
    NCT02015403 Institute of Liver and Biliary Sciences, India Ischemic Hepatitis December 2013
    NCT00568113 Assiut University Preterm Labour July 2007 Phase 4
    NCT01653171 Pontificia Universidad Catolica de Chile Stomach Neoplasms July 2012 Phase 4
    NCT01612221 University of Utah Patients at Risk for Melanoma September 2012 Phase 2
    NCT00188630 University Health Network, Toronto|Heart and Stroke Foundation of Ontario Heart Disease|Acute Renal Failure July 2003 Phase 3
    NCT02737358 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Nicotine Dependence August 2016 Phase 2
    NCT00808795 Tehran University of Medical Sciences Radiocontrast-Induced Nephropathy|Chronic Kidney Disease|Diabetes Mellitus April 2006 Phase 3
    NCT00391911 Royal Alexandra Hospital|University of Alberta|Gambro Renal Products, Inc. Rhabdomyolysis November 2006 Phase 2
    NCT00809094 Stanford University|Cystic Fibrosis Foundation Therapeutics Cystic Fibrosis November 2008 Phase 2
    NCT02123511 Mayo Clinic|National Cancer Institute (NCI) Mucositis|Oral Complications|Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Basal Cell Carcinoma of the Lip|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Lymphoepithelioma of the Oropharynx|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Recurrent Salivary Gland Cancer|Recurrent Squamous Cell Carcinoma of the Larynx|Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Recurrent Squamous Cell Carcinoma April 2014
    NCT00575419 Oregon Health and Science University Contrast Induced Nephropathy November 2007 Phase 1
    NCT00190034 Far Eastern Memorial Hospital|Synmosa Biopharma Corp. Cardiovascular Disease|Renal Insufficiency, Acute|Cardiopulmonary Bypass January 2005 Phase 4
    NCT00421785 Assaf-Harofeh Medical Center ESRD|Peritoneal Dialysis February 2007
    NCT01214083 VA Office of Research and Development Alcoholism October 2010 Phase 2
    NCT01394510 Utzschneider, Kristina, M.D.|VA Puget Sound Health Care System Type 2 Diabetes|Oxidative Stress June 2011
    NCT02249546 National Taiwan University Hospital Helicobacter Pylori Infection September 2014 Phase 4
    NCT01878695 Thomas Jefferson University Stage 0/1 Breast Cancer|Post Biopsy|Pre-surgery July 2012 Phase 1
    NCT00218491 Medical University of South Carolina|National Institute on Drug Abuse (NIDA) Cocaine Dependence November 2005 Phase 2
    NCT00497328 National University Hospital, Singapore Contrast Induced Nephropathy August 2007 Phase 2|Phase 3
    NCT01050270 University of Edinburgh|NHS Lothian|Chief Scientist Office of the Scottish Government Overdose September 2010 Phase 4
    NCT00187330 Sunnybrook Health Sciences Centre|The Physicians' Services Incorporated Foundation Heart Disease|Renal Insufficiency March 2004 Phase 2
    NCT02265224 Zambon SpA the Study Has Been Performed in Healthy Subjects September 2014 Phase 1
    NCT00203099 Teva Pharmaceutical Industries Relapse Remitting Multiple Sclerosis December 2004 Phase 2
    NCT02088502 Isfahan University of Medical Sciences Contrast-Induced Nephropathy September 2013 Phase 2|Phase 3
    NCT00483314 McGill University Health Center|March of Dimes Homocystinuria November 2007 Phase 2
    NCT01555970 University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo Obsessive-Compulsive Disorder March 2012 Phase 2
    NCT01172288 Yale University|American Academy of Child Adolescent Psychiatry. Tourettes Syndrome|Tic July 2010 Phase 2
    NCT01131572 Lindner Center of HOPE NAC February 2010 Phase 2|Phase 3
    NCT03018236 Hospital de Clinicas de Porto Alegre|Secretaria Nacional de Políticas sobre Drogas (SENAD) Cocaine Addiction|Alcohol Addiction January 2017 Phase 4
    NCT00569465 University of Turin, Italy Type 2 Diabetes Mellitus|Hypertension January 2005 Phase 4
    NCT02335060 Yale University Healthy March 2014 Phase 1
    NCT02094625 Children's Hospital Los Angeles Neuroectodermal Tumors, Primitive|Liver Neoplasms|Neoplasms, Germ Cell and Embryonal|Osteosarcoma|Other Childhood Cancers Using Cisplatin-based Regimens March 2016 Phase 1
    NCT01800526 Bloodworks (Puget Sound Blood Center)|University of Washington Sickle Cell Disease|Sickle Cell Anemia March 2013 Phase 1|Phase 2
    NCT01021163 Yonsei University Coronary Artery Occlusion Phase 4
    NCT00332631 Austin Health Cardiac Surgery and Cardiopulmonary Bypass August 2004 Phase 2
    NCT00611897 Yale University Cognitive Dysfunction January 2006 Phase 1|Phase 2
    NCT01005810 Medical University of South Carolina Cannabis Dependence September 2009 Phase 2
    NCT02141620 University of Kentucky|National Institute on Drug Abuse (NIDA) Cocaine Abuse|Cocaine Dependence May 2014 Early Phase 1
    NCT02707640 Hoffmann-La Roche Idiopathic Pulmonary Fibrosis August 2013 Phase 2
    NCT02994875 Yale University Cocaine Dependence May 2016 Early Phase 1
    NCT00493727 VA Office of Research and Development|West Virginia University Diabetes|Proteinuria September 2006
    NCT00539188 Yale University Borderline Personality Disorder|Self-Injurious Behavior September 2007 Phase 2
    NCT00396396 Eastern Virginia Medical School Creatinine Clearance October 2006
    NCT00915200 The University of Texas Health Science Center at San Antonio|National Center for Complementary and Integrative Health (NCCIH)|VA Office of Research and Development Diabetic Nephropathies|Proteinuria|Oxidative Stress October 2009 Phase 2
    NCT01015209 Medical University of Vienna Dry Eye Syndromes September 2010 Phase 1
    NCT00564642 National Research Institute of Tuberculosis and Lung Disease, Iran Hepatitis|Tuberculosis November 2007
    NCT01251029 Assaf-Harofeh Medical Center Chronic Kidney Diseases|General Anesthesia January 2011 Phase 1
    NCT01747616 Medical University of Vienna|Croma-Pharma GmbH Dry Eye Syndrome July 2011 Phase 1
    NCT01384591 The University of Texas Medical Branch, Galveston|Lantheus Medical Imaging|National Institutes of Health (NIH) Aging July 2011 Phase 1|Phase 2
    NCT02791945 University of California, San Francisco|United States Department of Defense|Northern California Institute of Research and Education|San Francisco Veterans Affairs Medical Center|Institute for Translational Neuroscience Traumatic Brain Injury (TBI)|Hazardous and Harmful Alcohol Use August 2016 Phase 2
    NCT02357290 Massachusetts General Hospital Bipolar Disorder January 2014 Phase 4
    NCT00428883 Università Politecnica delle Marche Scleroderma, Diffuse January 2007 Phase 2|Phase 3
    NCT00492518 Technische Universität München Contrast Induced Nephropathy|Kidney Diseases|Renal Failure|Adverse Effects February 2002 Phase 4
    NCT02719392 Massachusetts General Hospital Bipolar Disorder|Bipolar Depression September 2016 Phase 4
    NCT02750319 Memorial Sloan Kettering Cancer Center|Washington University School of Medicine|The Cleveland Clinic|Vanderbilt University School of Medicine Thoracic Surgery|Atrial Fibrillation in High Risk Patients April 2016 Phase 3
    NCT01017796 University of Thessaly Contrast Induced Nephropathy January 2009 Early Phase 1
    NCT01550432 Stanford University|National Center for Complementary and Integrative Health (NCCIH) Obesity|Hyperlipidemia|Insulin Resistance|Hypertension June 2011
    NCT00493610 VA Office of Research and Development|West Virginia University Hepatitis C November 2006
    NCT00969904 University Hospital, Antwerp COPD March 2009 Phase 4
    NCT01537926 The University of Texas Health Science Center, Houston|National Institutes of Health (NIH) Hypertrophic Cardiomyopathy January 2012 Phase 1
    NCT00775476 State University of New York - Upstate Medical University Systemic Lupus Erythematosus March 2009 Phase 1|Phase 2
    NCT00238173 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Bone Marrow Suppression|Brain and Central Nervous System Tumors|Drug/Agent Toxicity by Tissue/Organ|Long-term Effects Secondary to Cancer Therapy in Children December 2004 Phase 1
    NCT00650091 Duke University|National Heart, Lung, and Blood Institute (NHLBI) Pulmonary Fibrosis October 2009 Phase 3
    NCT00614757 Midwest Biomedical Research Foundation Insulin Resistance|Metabolic Syndrome x May 2005
    NCT00353340 Shaare Zedek Medical Center Acute Renal Failure Contrast Nephropathy January 2005
    NCT01424033 University of Michigan Interstitial Lung Disease|Connective Tissue Disease December 2011 Phase 2|Phase 3
    NCT03221231 Universitair Ziekenhuis Brussel Cannabis Use Disorder|Cannabis Dependence May 15, 2016 Phase 4
    NCT03104725 National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Parkinson Disease July 28, 2017
    NCT02182167 University of Cape Town|Medical Research Council, South Africa Drug-Induced Liver Injury May 2014 Phase 2|Phase 3
    NCT02499029 Medical University of South Carolina PTSD|Addiction February 2013 Phase 2
    NCT01111422 Ewha Womans University End-Stage Kidney Disease|Peritoneal Dialysis March 2010 Phase 4
    NCT02760901 Ain Shams University Cisplatin Nephrotoxicity November 2013 Phase 2
    NCT00247507 Far Eastern Memorial Hospital Anemia|Atherosclerosis|End-Stage Renal Disease|Oxidative Stress|Pro-Inflammation September 2005 Phase 4
    NCT00267384 Soroka University Medical Center Drug Induced Nephrotoxicity March 2006 Phase 2|Phase 3
    NCT00639496 Zambon SpA Pulmonary Fibrosis March 2000 Phase 3
    NCT03149107 University Hospital, Bonn|University of Cologne|Central Institute of Mental Health, Mannheim|Ludwig-Maximilians - University of Munich|University Hospital Tuebingen|Heinrich-Heine University, Duesseldorf|Charite University, Berlin, Germany|RWTH Aachen University Subjects Presenting Ultra-high Risk (UHR) for Psychosis September 2016 Phase 3
    NCT00004467 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|University of Texas Acute Liver Failure June 1998 Phase 3
    NCT00851708 University of Sao Paulo|Fundação de Amparo à Pesquisa do Estado de São Paulo Deceased Kidney Transplantation
    NCT00196885 German Cancer Research Center|Heidelberg University Gastrointestinal Neoplasms|Bronchial Carcinoma|Hodgkin Disease|Non-Hodgkin Lymphoma|Weight Loss December 2003 Phase 2
    NCT02966873 Medical University of South Carolina|National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health (NIH) Post Traumatic Stress Disorder (PTSD)|Addiction|Alcohol Abuse October 2016 Phase 2
    NCT00525551 Karolinska University Hospital|Karolinska Institutet|AstraZeneca Otosclerosis September 2007 Phase 4
    NCT01063205 Baylor College of Medicine|National Institute on Drug Abuse (NIDA) Methamphetamine Abuse|Methamphetamine Dependence|Substance Abuse March 2010 Phase 1
    NCT01265563 VA Office of Research and Development|National Center for Complementary and Integrative Health (NCCIH) Diabetic Nephropathy|Proteinuria|Oxidative Stress January 2011 Phase 2
    NCT01907061 Baylor Research Institute Acute Renal Failure July 2007
    NCT00237614 University of Milan Contrast-Induced Nephropathy|Acute Myocardial Infarction February 2003 Phase 2|Phase 3
    NCT01778309 Democritus University of Thrace Skeletal Muscle Damage|Skeletal Muscle Performance|Intgracellular Signaling in Skeletal Muscle|Inflammatory Status January 2010
    NCT02159196 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|ZonMw: The Netherlands Organisation for Health Research and Development Respiratory Failure July 2014
    NCT01037465 Boston University Cardiovascular Disease September 2008
    NCT02761577 Clinical Hospital Centre Zagreb Kidney Diseases|Contrast Media Reaction June 2012 Phase 4
    NCT01993849 Kevin Gray|Medical University of South Carolina Onychophagia October 2013 Phase 3
    NCT00399256 Robert Bosch Gesellschaft für Medizinische Forschung mbH Chronic Kidney Failure March 2004
    NCT01138137 OHSU Knight Cancer Institute Ovarian Carcinoma, Stage 3 or 4|Epithelial Ovarian Carcinoma|Primary Peritoneal Carcinoma June 2010 Phase 1
    NCT01187108 University of Colorado, Denver|Universidad Peruana Cayetano Heredia|Jackson, Brian, M.S.|Thomas H Maren Foundation Erythrocytosis|Mountain Sickness June 2013 Phase 1|Phase 2
    NCT00184977 Radboud University|Dutch Health Care Insurance Board (CVZ)|GlaxoSmithKline|Zambon SpA|The Netherlands Asthma Foundation Pulmonary Disease, Chronic Obstructive|Lung Diseases, Obstructive|Bronchitis, Chronic December 1998 Phase 4
    NCT02971306 Postgraduate Institute of Medical Education and Research Alcoholic Hepatitis July 2014 Phase 4
    NCT00507052 Assaf-Harofeh Medical Center Hemodialysis|Renal Failure
    NCT01753752 Gerhard Garhofer|Croma-Pharma GmbH|Medical University of Vienna Dry Eye Syndrome September 2012 Phase 2
    NCT01905696 Duke University Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation March 2013 Early Phase 1
    NCT01495260 Onofre, Aurora Pujol, M.D.|Ministerio de Sanidad, Servicios Sociales e Igualdad|Fundacion Hesperia Adrenomyeloneuropathy September 2011 Phase 2
    NCT02723162 Medical University of South Carolina Nicotine Dependence, Cigarettes January 2016
    NCT01891292 The University of The West Indies|Caribbean Health Research Council Microalbuminuria|Sickle Cell Nephropathy July 2013
    NCT00188773 University Health Network, Toronto Insulin Resistance Syndrome X|Pancreatic Beta Cell Function January 2004 Phase 4
    NCT02930031 National and Kapodistrian University of Athens Skeletal Muscle Damage|Aseptic Inflammation|Skeletal Muscle Function January 2015
    NCT02583672 University of Minnesota - Clinical and Translational Science Institute|Rare Diseases Clinical Research Network|National Center for Advancing Translational Science (NCATS)|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institute of Neurological Disorders and Stroke (NINDS)|Lysosomal Disease Network Gaucher Disease Type 1 September 2015 Phase 2
    NCT02348762 Baylor College of Medicine Aging|Erythrocyte Glutathione Deficiency|Muscle Weakness November 2014 Phase 1
    NCT02348775 Baylor College of Medicine HIV Infection|Erythrocyte Glutathione Deficiency November 2014 Phase 1
    NCT01386645 Seattle Institute for Biomedical and Clinical Research|VA Puget Sound Health Care System Impaired Glucose Tolerance|Oxidative Stress|Prediabetes|Impaired Fasting Glucose July 2011
    NCT00655928 Imperial College London|Royal College of Physicians|Royal Brompton & Harefield NHS Foundation Trust Acute Lung Injury August 2007 Phase 2
    NCT02818270 Chang Gung University|Chang Gung Memorial Hospital Chronic Obstructive Pulmonary Disease June 2016
    NCT00716001 Osaka General Medical Center Chronic Renal Failure July 2008 Phase 4
    NCT02206178 University Hospital, Clermont-Ferrand|Gisèle PICKERING, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital|Christian DUALE, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital|Gilles DUCHEIX, Clinical Pharmacology Center, Inserm 1405, Clermont-Ferrand Hospital Healthy September 2013 Phase 1
    NCT00463671 Assaf-Harofeh Medical Center Diabetic Foot Ulcers December 2003
    NCT02362425 National Institute of Nursing Research (NINR)|National Institutes of Health Clinical Center (CC) Neuromuscular Disease January 21, 2015 Phase 1|Phase 2
    NCT00585559 Vanderbilt University|National Institutes of Health (NIH)|National Institute of General Medical Sciences (NIGMS)|Vanderbilt University Medical Center Aneurysmal Subarachnoid Hemorrhage|Cerebral Vasospasm April 2007
    NCT01355198 Baylor College of Medicine HIV Infection|Erythrocyte Glutathione Deficiency August 2010 Phase 1
    NCT02911285 Medical University of South Carolina|United States Department of Defense|Institute for Translational Neuroscience Posttraumatic Stress Disorder (PTSD)|Alcohol Use Disorder (AUD) October 2016 Phase 2
    NCT00467831 National Human Genome Research Institute (NHGRI)|National Institutes of Health Clinical Center (CC) Hermansky-Pudlak Syndrome (HPS)|Pulmonary Fibrosis|Oculocutaneous Albinism|Platelet Storage Pool Deficiency|Metabolic Disease April 2007 Phase 1|Phase 2
    NCT01699204 University of British Columbia Asthma September 2007
    NCT00552786 National Taiwan University Hospital|Institute of Occupational Safety and Health, Taiwan|Municipal Hospital of Tainan, Taiwan Hearing Loss November 2007 Phase 2
    NCT01564303 The Nazareth Hospital|Western Galilee Hospital-Nahariya|The Nazareth Hospital, Israel Contrast Media Induced Nephropathy May 2012
    NCT03220776 Medical University of South Carolina|National Institutes of Health (NIH)|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Alcohol Use Disorder|Bipolar Disorder August 1, 2017 Phase 2
    NCT01597765 Mahidol University|ChaingMai University Thalassemia June 2009
    NCT01467466 VA Office of Research and Development|The George Institute Acute Renal Failure|Kidney Disease|Coronary Artery Disease February 7, 2013 Phase 3
    NCT02294591 Region Syddanmark Bipolar Disorder November 2014 Phase 2
    NCT02168387 Duke University Atelectasis December 2010 Phase 4
    NCT02476526 VA Greater Los Angeles Healthcare System|General Electric Chronic Kidney Disease|Pulmonary Embolism|Renal Artery Stenosis|Pulmonary Cancer September 2008 Phase 4
    NCT00434005 University of Washington|National Institutes of Health (NIH) Healthy July 2008
    NCT02040818 University of California, San Diego|National Institutes of Health (NIH) Hemodialysis Catheter-related Bacteremia November 2013 Phase 2|Phase 3
    NCT00592618 Assaf-Harofeh Medical Center ESRD|Sleep Apnea
    NCT02269540 Centre for Addiction and Mental Health Major Depressive Disorder October 2014 Early Phase 1
    NCT01870193 Rajagopal V Sekhar|National Institute on Aging (NIA)|Baylor College of Medicine Aging October 2012
    NCT02882477 Hadassah Medical Organization Diabetes Mellitus|Iron Metabolism Disorders|Gastroduodenal Ulcer|Optic Atrophy|Sensorineural Hearing Loss|Platelet Dysfunction December 2016 Phase 2|Phase 3
    NCT01188005 University of Athens Obstructive Sleep Apnea Syndrome August 2010
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    References
    Preparing Stock Solutions
    Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
    1 mM 6.1278 mL 30.6391 mL 61.2783 mL
    5 mM 1.2256 mL 6.1278 mL 12.2557 mL
    10 mM 0.6128 mL 3.0639 mL 6.1278 mL
    Cell Assay
    [2]

    For survival experiments, washed cells are resuspended in RPM1 1640 medium and plated in 0.5 mL at a density of 8-10×105 per well in 24 well plastic culture dishes coated with rat tail collagen. To feed, but to avoid loss of floating cells, fresh medium (0.2 mL) is added to the cultures on days 1, 5, and 10. For experiments involving “primed” PC12 cells, cultures are pretreated for l-2 weeks with NGF in RPM1 1640 medium supplemented with 1% heat-iN-acetylcysteinetivated horse serum. The cells are then washed and passaged into serum-free RPM1 1640 medium. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [1]

    Rats are randomLy allocated into five groups: sham group (n=5), control group with IIR (n=8) and three groups with IIR who are given N-acetylcysteine in different dosages: 150 mg/kg intraperitoneally 5 min before ischemia (n=8, group N-acetylcysteine 150), 300 mg/kg i.p 5 min before ischemia (n=7, group N-acetylcysteine 300), and 150 mg/kg i.p 5 min before ischemia plus 150 mg/kg 5 min before reperfusion (n=7, group N-acetylcysteine 150 + 150). After 4 h of reperfusion, the animals are euthanized by exsanguination from the abdominal aorta. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    163.19

    Formula

    C₅H₉NO₃S

    CAS No.

    616-91-1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    Acetylcysteine
    Cat. No.:
    HY-B0215
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