1. Apoptosis
  2. IAP


IAP (Inhibitors of Apoptosis) is a family of functionally and structurally related proteins, which serve as endogenous inhibitors of programmed cell death (apoptosis). A common feature of all IAPs is the presence of a BIR in one to three copies. The human IAP family consists of 8 members, and IAP homologs have been identified in numerous organisms. The members of the IAPs included IAPs, Cp-IAP, Op-IAP, XIAP, c-IAPl, C-IAP2, NAIP, Livin and Survivin. The best characterized IAP is XIAP, which binds caspase-9, caspase-3 and caspase 7, thereby inhibiting their activation and preventing apoptosis. Also cIAP1 and cIAP2 have been shown to bind caspases, although how the IAPs inhibit apoptosis mechanistically at the molecular level is not completely understood.

IAP Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-15518
    LCL161 Inhibitor 99.17%
    LCL161 is a novel IAP inhibitor, inhibits XIAP activity in HEK293 cell with IC50 of 35 nM, also inhibits cIAP1 activity in MDA-MB-231 cell with IC50 of 0.4 nM.
  • HY-16591
    Birinapant Antagonist 99.84%
    Birinapant a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kd values of 45 nM and < 1 nM, respectively.
  • HY-16701
    BV6 Antagonist 99.09%
    BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.
  • HY-13638
    GDC-0152 Inhibitor 98.73%
    GDC-0152 is a potent inhibitor of IAPs which binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with Ki values of 28, 14, 17, and 43 nM, respectively.
  • HY-12600
    AZD5582 Antagonist 99.47%
    AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively).
  • HY-109565
    ASTX660 Antagonist
    ASTX660 is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP).
  • HY-15835
    CUDC-427 Inhibitor 99.60%
    CUDC-427 is a potent second-generation pan-selective IAP antagonist, used for treatment of various cancers.
  • HY-15989
    SM-164 Inhibitor >98.0%
    SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
  • HY-17473
    Embelin Antagonist 98.02%
    Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties.
  • HY-100892
    MX69 Inhibitor 98.59%
    MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
  • HY-12842
    UC-112 Inhibitor
    UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).