1. Apoptosis
  2. IAP

IAP

IAP (Inhibitors of Apoptosis) is a family of functionally and structurally related proteins, which serve as endogenous inhibitors of programmed cell death (apoptosis). A common feature of all IAPs is the presence of a BIR in one to three copies. The human IAP family consists of 8 members, and IAP homologs have been identified in numerous organisms. The members of the IAPs included IAPs, Cp-IAP, Op-IAP, XIAP, c-IAPl, C-IAP2, NAIP, Livin and Survivin. The best characterized IAP is XIAP, which binds caspase-9, caspase-3 and caspase 7, thereby inhibiting their activation and preventing apoptosis. Also cIAP1 and cIAP2 have been shown to bind caspases, although how the IAPs inhibit apoptosis mechanistically at the molecular level is not completely understood.

IAP Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-16591
    Birinapant Antagonist
    Birinapant a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kd values of 45 nM and < 1 nM, respectively.
  • HY-15518
    LCL161 Inhibitor
    LCL161 is a novel IAP inhibitor, inhibits XIAP activity in HEK293 cell with IC50 of 35 nM, also inhibits cIAP1 activity in MDA-MB-231 cell with IC50 of 0.4 nM.
  • HY-13638
    GDC-0152 Inhibitor
    GDC-0152 is a potent inhibitor of IAPs which binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with Ki values of 28, 14, 17, and 43 nM, respectively.
  • HY-16701
    BV6 Antagonist
    BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.
  • HY-15835
    CUDC-427 Inhibitor
    CUDC-427(GDC-0917) is a small-molecule peptide mimetic of SMAC/DIABLO; directly antagonize inhibitors of apoptosis proteins (IAPs).
  • HY-100892
    MX69 Inhibitor
    MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
  • HY-12600
    AZD5582 Antagonist
    AZD5582 is a novel class of dimeric Smac mimetics as potent IAP antagonist; binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively).
  • HY-17473
    Embelin Antagonist
    Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitiv
  • HY-15989
    SM-164 Inhibitor
    SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
  • HY-12842
    UC-112 Inhibitor
    UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).