2. Signaling Pathways
  3. Apoptosis
  4. IAP
  5. XIAP Isoform

XIAP

 
Cat. No. Product Name Effect Purity
  • HY-12600
    AZD5582
    		Antagonist 98.11%
    AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.
  • HY-15454
    Xevinapant
    		Antagonist 99.94%
    Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with Ki of 66.4, 1.9, and 5.1 nM, respectively.
  • HY-17473
    Embelin
    		Antagonist 98.75%
    Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP.
  • HY-13208
    Xevinapant hydrochloride
    		Antagonist 98.80%
    Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs).
  • HY-110346
    AZD5582 dihydrochloride
    		Antagonist 98.67%
    AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.
  • HY-151966
    TD1092
    		Degrader
    TD1092 is a pan-IAP.html" class="link-product" target="_blank">IAP degrader, degrades cIAP1, cIAP2, and XIAP.
  • HY-100682
    T-3256336
    		Inhibitor
    T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively.
  • HY-125378
    SBP-0636457
    		Antagonist 98.42%
    SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist.
  • HY-102051
    XIAP/cIAP1 antagonist-1
    		Inhibitor
    XIAP/cIAP1 antagonist-1 is a potent and orally active XIAP/cIAP1 antagonist with EC50s of 5.1 nM and 0.32 nM for XIAP and cIAP1, respectively.
Cat. No. Product Name / Synonyms Species Source