2. PROTAC Apoptosis
  3. PROTACs IAP Caspase
  4. TD1092

TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research.

For research use only. We do not sell to patients.

TD1092 Chemical Structure

TD1092 Chemical Structure

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TD1092 Related Antibodies

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Description

TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research[1].

IC50 & Target[1]

cIAP1

 

cIAP2

 

XIAP

 

Caspase 3

 

Caspase-7

 

In Vitro

TD1092 (0.1 μM-10 μM; 0.5-6 h) potently degrades cIAP1, cIAP2, and XIAP in a dose- and time-dependent manner[1].
TD1092 (0.01, 0.1 and 1 μM; 18 h) activates caspase 3/7 in MCF-7 cells[1].
TD1092 (1 μM; 48 h and 72 h) promotes cancer cell death[1].
TD1092 (0.1 μM; 24 h) inhibits TNFα-induced migration and invasion against triple-negative breast cancer cells[1].
TD1092 (1 μM; 6 h) inhibits TNFα-induced NF-κB signaling pathway and epithelial-mesenchymal transition (EMT) via IAP degradation[1].
TD1092 (1 μM; 72 h) inhibits MCF-7 cells growth with an IG50 value of 0.395 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TD1092 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: (1) 0, 0.1, 1, 10 μM or 0.1 μM
(2) 0.1 μM, with or without 100 ng/mL TNFα
Incubation Time: 18 hours or 0.5, 1, 2, 4, 6 hours for (1) and 4 hours for (2)
Result: Dose- and time-dependently decreases the protein level of cIAP1, cIAP2, and XIAP.
Inhibited the phosphorylation of IKK, IkBα, p65, and p38 mediated by TNFα.
Counterbalanced the effect of TNFα on the levels of E-cadherin (CDH1; an epithelial marker) and vimentin (VIM; a mesenchymal marker).

Cell Migration Assay [1]

Cell Line: MDA-MB-231 and MDA-MB-157 cells
Concentration: 0.1 μM; with or without 100 ng/mL TNFα
Incubation Time: 24 hours
Result: Inhibited TNFα-induced (100 ng/mL) migration and invasion against two triple-negative breast cancer (TNBC; MDA-MB-231 and MDA-MB-157) cell lines.
Molecular Weight

987.19

Formula

C55H70N8O9
SMILES

O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C(C)(C)C)=O)CC4=C(C=CC(OCCCCCCCCNC(C(C5)CN5C(C=C6C7=O)=CC=C6C(N7C8CCC(NC8=O)=O)=O)=O)=C4)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TD1092 Related Classifications

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TD1092TD 1092TD-1092PROTACsIAPCaspaseInhibitorinhibitorinhibit

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