Caspase-13

Caspase-13 was first described as ERICE, an ICE-subfamily caspase linked to apoptosis and inflammation^[1]. Mechanistically, ERICE overexpression induced apoptosis in 293 and MCF7 cells, and caspase-8 activated ERICE in a death-receptor pathway^[1]. However, later evidence showed bovine, not human, peripheral blood mononuclear cells express caspase-13^[2]. Therefore, caspase-13 should be treated as a bovine gene, not a validated human target^[2]. Compared with related inflammatory isoforms, caspase-13 represents the bovine homolog of human caspase-4^[3]. For research design, caspase-13 evidence best supports comparative caspase biology and bovine immune-cell models, while human studies should focus on CASP4 rather than CASP13^[2]^[3].

References:

[1]. Humke EW, et al. ERICE, a novel FLICE-activatable caspase. J Biol Chem. 1998 Jun 19;273(25):15702-7.

[2]. Koenig U, et al. Evidence that caspase-13 is not a human but a bovine gene. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1150-4.

[3]. Lee MJ, et al. Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial. Lancet HIV. 2026 May 27:S2352-3018(26)00059-7.

Caspase-13 Inhibitor (1)

Caspase-13 Related Products (1):

By Type:	Pan (1)

Cat. No.	Product Name	Effect	Purity

HY-P5122

Z-LEED-FMK	Inhibitor
Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages.

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