Caspase-13
Caspase-13 was first described as ERICE, an ICE-subfamily caspase linked to apoptosis and inflammation[1]. Mechanistically, ERICE overexpression induced apoptosis in 293 and MCF7 cells, and caspase-8 activated ERICE in a death-receptor pathway[1]. However, later evidence showed bovine, not human, peripheral blood mononuclear cells express caspase-13[2]. Therefore, caspase-13 should be treated as a bovine gene, not a validated human target[2]. Compared with related inflammatory isoforms, caspase-13 represents the bovine homolog of human caspase-4[3]. For research design, caspase-13 evidence best supports comparative caspase biology and bovine immune-cell models, while human studies should focus on CASP4 rather than CASP13[2][3].
References:
- [1]. Humke EW, et al. ERICE, a novel FLICE-activatable caspase. J Biol Chem. 1998 Jun 19;273(25):15702-7. [Content Brief]
- [2]. Koenig U, et al. Evidence that caspase-13 is not a human but a bovine gene. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1150-4. [Content Brief]
- [3]. Lee MJ, et al. Time to HIV rebound after infusion of long-acting broadly neutralising antibodies 3BNC117-LS and 10-1074-LS and analytical treatment interruption (the RIO trial): a double-blind, randomised, placebo-controlled trial. Lancet HIV. 2026 May 27:S2352-3018(26)00059-7. [Content Brief]
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Z-LEED-FMK
0 ImagesCat. No.: HY-P5122CAS No.: 1135688-38-8Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages.
