1. Metabolic Enzyme/Protease
  2. Elastase

Elastase

Elastases are proteinases capable of solubilizing fibrous elastin. Elastases may belong to the class of serine proteinases, cysteine proteinases and metalloproteinases. Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. One may measure this activity using native or labelled elastins. With pure elastases one may use synthetic substrates. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.

Elastase Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-15891
    GW311616 Inhibitor 99.30%
    GW311616 is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM; free base form of GW311616A.
  • HY-17443B
    Sivelestat sodium tetrahydrate Inhibitor >98.0%
    Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.
  • HY-75957
    DMP 777 Inhibitor 99.52%
    DMP 777(L-694458) is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
  • HY-15651
    Alvelestat Inhibitor
    Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9 for Human NE.
  • HY-17443
    Sivelestat Inhibitor
    Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.
  • HY-17443A
    Sivelestat sodium Inhibitor
    Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.
  • HY-15891A
    GW311616 hydrochloride Inhibitor
    GW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM.