PKC-nu

PKC-nu (protein kinase C nu, PRKD2) is a serine/threonine kinase belonging to the protein kinase D subfamily rather than to the classical PKC isoforms. Like PKCμ (PRKD1), it carries an N-terminal regulatory region with C1 domains and a PH domain, and diacylglycerol-dependent translocation precedes its activation. PKC-nu regulates vesicular trafficking from the trans-Golgi network to the plasma membrane and contributes to signaling downstream of heterotrimeric G proteins and receptor tyrosine kinases. Altered PRKD2 expression is associated with several cancers, and the enzyme participates in insulin secretion and inflammatory signaling.