1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. VDAC

VDAC

Voltage-dependent anion channels (VDACs) are a class of porin ion channel located on the outer mitochondrial membrane. This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules. The voltage-dependent ion channel plays a key role in regulating metabolic and energetic flux across the outer mitochondrial membrane. Additionally, VDAC is an important regulator of Ca2+ transport in and out of the mitochondria.

VDAC Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin Inhibitor 99.57%
    Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
  • HY-128777
    WEHI-9625 Inhibitor
    WEHI-9625 is a tricyclic sulfone small molecule inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK, but is completely inactive against both human BAK and the closely related apoptosis effector BAX.
  • HY-108937
    NSC 15364 Inhibitor
    NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
Isoform Specific Products

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