1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. VDAC

VDAC

Voltage-dependent anion channel

VDAC (voltage-dependent anion selective channel) proteins, also known as mitochondrial porins, are the most abundant proteins of the outer mitochondrial membrane (OMM) where they play a vital role in various cellular processes, in the regulation of metabolism, and in survival pathways. They mediate the ions (such as Ca2+) and metabolites (such as succinate or ATP, tRNA or DNA) exchange between mitochondria and the rest of the cell, ensuring good functionality of mitochondrial complexes and energy production.

In higher eukaryotes, there are three VDAC isoforms (VDAC1, VDAC2, VDAC3) encoded by separate genes located on different chromosomes. VDAC has the potential for the research of cancer and Alzheimer's disease.

VDAC Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin
    Inhibitor 99.76%
    Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
  • HY-D0086
    DIDS sodium salt
    Inhibitor 99.13%
    DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor.
  • HY-108937
    NSC 15364
    Inhibitor 99.27%
    NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis.
  • HY-128777
    WEHI-9625
    Inhibitor 99.05%
    WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.