1. Metabolic Enzyme/Protease
    Apoptosis
  2. Mitochondrial Metabolism
    Apoptosis
  3. AKOS-22

AKOS-22 

Cat. No.: HY-111217
Handling Instructions

AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction.

For research use only. We do not sell to patients.

AKOS-22 Chemical Structure

AKOS-22 Chemical Structure

CAS No. : 878983-38-1

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Description

AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction[1].

IC50 & Target

Kd: 15.4 μM (VDAC1)[1]

In Vitro

AKOS-22 (5-20 μM; 2 hours) inhibits both VDAC1 oligomerization and apoptosis in a concentration-dependent manner (IC50=7.5 μM)[1].
AKOS-22 inhibits selenite-induced VDAC1 oligomerization, Cyto c release and apoptosis in HEK-293 cells (IC50=3.3-3.6 μM). AKOS-22 (30 μM, 2 h) inhibits cisplatin-induced VDAC1 oligomerization and apoptosis in neuroblastoma cell line SH-SY5Y. AKOS-22 prevents the elevation of [Ca2+]I associated with apoptosis induction, and thus Ca2+ accumulation by the mitochondria[1].

Molecular Weight

467.87

Formula

C₂₂H₂₁ClF₃N₃O₃

CAS No.

878983-38-1

SMILES

O=C(C(N1CCC(NC2=CC=C(OC(F)(F)F)C=C2)CC1)C3)N(C4=CC=C(Cl)C=C4)C3=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AKOS-22AKOS22AKOS 22Mitochondrial MetabolismApoptosisMitochondrialproteindysfunction, oligomerizationapoptogenicCyto creleasInhibitorinhibitorinhibit

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