TIE-1
TIE-1 is an endothelium-restricted receptor tyrosine kinase that combines immunoglobulin-like and EGF-like ectodomains with three fibronectin type III repeats. Unlike its family partner TIE-2, no unequivocal activating ligand has been established, and TIE-1 is generally considered an orphan or modulatory receptor. It forms heterodimers with TIE-2 and fine-tunes angiopoietin-driven signaling, and mouse genetics shows TIE-1 is required for vascular maturation and vessel integrity during development and quiescence. A circulating cleaved ectodomain, TIE1ECD, rises in sepsis and preeclampsia, supporting its use as an endothelial activation biomarker in critical care. These features position TIE-1 as both a modulator of angiopoietin signaling and a source of clinically informative circulating fragments.
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TIE-1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
