1. Metabolic Enzyme/Protease
  2. Fatty Acid Synthase (FAS)

Fatty Acid Synthase (FAS)

Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.

Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.

Fatty Acid Synthase (FAS) Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-B0218
    Orlistat Inhibitor 99.75%
    Orlistat is a lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.
  • HY-12364
    C75 Inhibitor 99.86%
    C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM.
  • HY-A0210
    Cerulenin Inhibitor >99.0%
    Cerulenin, the best known natural inhibitor of fatty acid synthase (FAS), is an epoxide produced by the fungus Cephalosporium caeruleus.
  • HY-12364A
    C75 trans Inhibitor 99.71%
    C75 trans is an enantiomer of C75. C75 is a synthetic fatty-acid synthase (FASN) inhibitor.
  • HY-12648A
    FAS-IN-1 Tosylate Inhibitor 99.30%
    FAS-IN-1 tosylate is a potent inhibitor of fatty acid synthase (FAS) extracted from patent WO 2012064642 A1, compound 29; has an IC50 of 10 nM.
  • HY-111551
    FT113 Inhibitor
    FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer both in vitro and in vivo.
  • HY-12648
    FAS-IN-1 Inhibitor
    FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM, extracted from Patnet WO2012/064642Al.
  • HY-U00436
    FASN inhibitor 1 Inhibitor
    FASN inhibitor 1 is a fatty acid synthase (FASN) inhibitor extracted from patent US20170119786A1, compound 242A.
  • HY-112522
    HS79 Inhibitor
    HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM.
  • HY-112522A
    HS80 Inhibitor
    HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM.
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