1. Metabolic Enzyme/Protease
  2. Fatty Acid Synthase (FAS)
  3. Fatostatin hydrobromide

Fatostatin hydrobromide (Synonyms: 125B11 hydrobromide)

Cat. No.: HY-14452A
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Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.

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Fatostatin hydrobromide Chemical Structure

Fatostatin hydrobromide Chemical Structure

CAS No. : 298197-04-3

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 78 In-stock
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25 mg USD 145 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2].

In Vitro

Fatostatin hydrobromide (125B11 hydrobromide) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC50=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin hydrobromide inhibits insulin-induced adipogenesis of 3T3-L1 cells[1].

Cell Proliferation Assay[1]

Cell Line: DU-145 cells
Concentration: 0.1, 1 μM
Incubation Time: 3 days
Result: Impaired the IGF1-induced growth at an IC50 of 0.1 μM.
In Vivo

Fatostatin hydrobromide (125B11 hydrobromide) (30 mg/kg; 150 mL; i.p.; daily for 28 days) reduces adiposity, ameliorates fatty liver by reducing triglyceride (TG) storage, and lowers hyperglycemia in ob/ob mice[2].

Animal Model: Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)[2]
Dosage: 30 mg/kg; 150 mL
Administration: i.p. injection; daily for 28 days
Result: Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
Molecular Weight

375.33

Formula

C₁₈H₁₉BrN₂S

CAS No.

298197-04-3

SMILES

CCCC1=NC=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=C1.[H]Br

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Fatostatin125B11Fatty Acid Synthase (FAS)GolgiSREBP-mediatedgeneexpressionhumanprostatecancerinsulin-inducedadipogenesisob/obmiceInhibitorinhibitorinhibit

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Fatostatin hydrobromide
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