1. Protein Tyrosine Kinase/RTK
  2. Syk

Syk

Syk (Spleen tyrosine kinase) is an enzyme which in humans is encoded by the SYK gene. Syk, along with Zap-70, is a member of the Syk family of tyrosine kinases. Syk is known to have a crucial role in adaptive immune receptor signalling. Recent reports indicate that Syk also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. Syk is activated by C-type lectins and integrins, and activates new targets, including the CARD9-Bcl-10-MALT1 pathway and the NLRP3 inflammasome. Syk has a crucial role in autoimmune diseases and haematological malignancies.

Syk Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-15968
    GS-9973 Inhibitor 99.03%
    GS-9973 is a highly selective and orally efficacious Syk inhibitor(IC50= 7.7 nM) which is currently undergoing clinical evaluation for autoimmune and oncology indications.
  • HY-14985
    BAY 61-3606 dihydrochloride Inhibitor 98.74%
    BAY 61-3606 (dihydrochloride) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase (IC50=10 nM) with no inhibitory effect on Btk, Fyn, Itk, Lyn, and Src.
  • HY-15999
    Cerdulatinib Inhibitor
    Cerdulatinib is a novel, orally available, ATP-competitive inhibitor that demonstrates selective inhibition of SYK and JAK kinases with IC50 of 32 nM for SYK and 0.5-12 nM for JAKs.
  • HY-12067
    R406 Inhibitor
    R406 is a competitive Syk inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value.
  • HY-13038B
    R788 disodium hexahydrate Inhibitor 98.87%
    R788 sodium salt hydrate (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
  • HY-100867A
    TAK-659 hydrochloride Inhibitor 98.13%
    TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.
  • HY-15323
    PRT062607 Hydrochloride Inhibitor 99.20%
    PRT062607 hydrochloride is a highly specific and potent inhibitor of purified Syk (IC50 1-2 nM).
  • HY-13518
    Piceatannol Inhibitor 99.49%
    Piceatannol is a selective inhibitor of protein tyrosine kinase Syk.
  • HY-16902
    RO9021 Inhibitor 99.56%
    RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM.
  • HY-13038
    R788(prodrug of R406) Inhibitor 98.79%
    R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
  • HY-13038A
    R788 Inhibitor
    R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
  • HY-11108
    R406 free base Inhibitor 99.73%
    R406 is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3.
  • HY-12974
    PRT-060318 Inhibitor 98.01%
    PRT-060318 (PRT318) is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4 nM.
  • HY-76474
    BAY 61-3606 Inhibitor
    BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
  • HY-16420
    R112 Inhibitor
    R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM.
  • HY-78263
    MNS Inhibitor
    MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.
  • HY-15322
    PRT062607 Inhibitor
    PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.