1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Sirtuin
  4. SIRT1 Isoform



SIRT1 Related Products (43):

Cat. No. Product Name Effect Purity
  • HY-123033A
    Nicotinamide riboside chloride
    Activator 99.53%
    Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3.
  • HY-108331
    Inhibitor 99.93%
    3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
  • HY-107454
    Inhibitor 98.06%
    OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
  • HY-15145
    SRT 1720 Hydrochloride
    Activator 99.92%
    SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.
  • HY-B0879A
    Suramin sodium salt
    Inhibitor ≥98.0%
    Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor.
  • HY-150727
    SIRT5 inhibitor 4
    SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.
  • HY-146013
    Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively.
  • HY-148312
    Sirtuin modulator 4
    Sirtuin modulator 4 (compound 12) is a sirtuin modulator.
  • HY-10532
    SRT 1720
    Activator 99.82%
    SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.
  • HY-100578
    Inhibitor 99.62%
    AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 μM.
  • HY-15262
    SRT 2104
    Activator 99.76%
    SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA.
  • HY-13515
    Inhibitor ≥98.0%
    Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
  • HY-101278
    Inhibitor 98.37%
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
  • HY-15510
    Inhibitor 98.67%
    Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity.
  • HY-19759
    SRT 2183
    Activator 98.17%
    SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM.
  • HY-100732
    Inhibitor 99.70%
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively.
  • HY-124037
    SRT 1460
    Activator 98.92%
    SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues.
  • HY-104073
    Activator 98.65%
    CAY10602 is a SIRT1 activator.
  • HY-N0704
    Agrimol B
    Activator 99.75%
    Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator.
  • HY-15869
    Inhibitor 99.49%
    Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer.