1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. Sirtuin
  4. SIRT1 Inhibitors

SIRT1 Inhibitors

Sirtuin

SIRT1

SIRT2

SIRT3

SIRT6

SIRT5

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Sorry. There is currently no product that acts on isoform SIRT1 together.

Please try each isoform separately.

SIRT1 Specific Inhibitors, Activators & Modulators
Product Name SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT1 Selectivity Purity
Selisistat
SIRT1, IC50: 98 nM
SIRT2, IC50: 19.6 μM
SIRT3, IC50: 48.7 μM
    Selective Inhibitor 99.85%
SRT 1720 Hydrochloride
SIRT1, EC1.5: 0.16 μM
SIRT1, EC50: 0.10 μM
SIRT2, EC1.5: 37 μM
      Selective Activator 99.92%
SRT 2104
SIRT1
        Selective Activator 98.87%
CAY10602
SIRT1
        Selective Activator 98.65%
Selisistat S-enantiomer
SIRT1, IC50: 123 nM
        Selective Inhibitor 98.50%
Sirtuin modulator 1
SIRT1, EC1.5: 1 μM
        Selective Modulator 99.44%
SRT 1720
SIRT1, EC1.5: 0.16 μM
SIRT2, EC1.5: 37 μM
      Selective Activator
SRT 2183
SIRT1, EC1.5: 0.36 μM
        Selective Activator 98.48%
Inauhzin
SIRT1
        Selective Inhibitor 99.49%
SRT 1460
SIRT1, EC1.5: 2.9 μM
        Selective Activator
Suramin sodium salt
SIRT1, IC50: 297 nM
SIRT2, IC50: 1.15 μM
   
SIRT5, IC50: 22 μM
Pan Inhibitor 99.93%
Scopolin
SIRT1
        Pan Activator >99.0%
3-TYP
SIRT1, IC50: 88 nM
SIRT2, IC50: 92 nM
SIRT3, IC50: 16 nM
    Pan Inhibitor 99.87%
Nicotinamide riboside chloride
SIRT1
 
SIRT3
    Pan Activator 99.20%
OSS_128167
SIRT1, IC50: 1578 μM
SIRT2, IC50: 751 μM
 
SIRT6, IC50: 89 μM
  Pan Inhibitor 98.22%
Sirtinol
ySir2, IC50: 48 μM
hSIRT1, IC50: 131 μM
hSIRT2, IC50: 57.7 μM
      Pan Inhibitor >98.0%
Tenovin-6
SIRT1, IC50: 21 μM
SIRT2, IC50: 10 μM
SIRT3, IC50: 67 μM
    Pan Inhibitor 98.61%
Thiomyristoyl
SIRT1, IC50: 98 μM
SIRT2, IC50: 28 nM
      Pan Inhibitor 98.94%
Cambinol
SIRT1, IC50: 56 μM
SIRT2, IC50: 59 μM
      Pan Inhibitor 99.70%
AGK2
SIRT1, IC50: 30 μM
SIRT2, IC50: 3.5 μM
SIRT3, IC50: 91 μM
    Pan Inhibitor 98.66%
Salermide
SIRT1
SIRT2
      Pan Inhibitor >98.0%
Tenovin-6 Hydrochloride
SIRT1, IC50: 21 μM
SIRT2, IC50: 10 μM
SIRT3, IC50: 67 μM
    Pan Inhibitor >98.0%
Suramin
SIRT1, IC50: 297 nM
SIRT2, IC50: 1.15 μM
   
SIRT5, IC50: 22 μM
Pan Inhibitor
Ophiopogonin D'
SIRT1
        Pan Activator 99.85%
Agrimol B
SIRT1
        Pan Activator
Dihydrocoumarin
hSIRT1, IC50: 208 μM
hSIRT2, IC50: 295 μM
      Pan Inhibitor 99.81%
SIRT-IN-1
SIRT1, IC50: 15 nM
SIRT2, IC50: 10 nM
SIRT3, IC50: 33 nM
    Pan Inhibitor
SIRT-IN-2
SIRT1, IC50: 4 nM
SIRT2, IC50: 1 nM
SIRT3, IC50: 7 nM
    Pan Inhibitor
Nicotinamide riboside
SIRT1
 
SIRT3
    Pan Activator