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  3. Nicotinamide riboside chloride

Nicotinamide riboside chloride 

Cat. No.: HY-123033A Purity: 99.20%
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Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.

For research use only. We do not sell to patients.

Nicotinamide riboside chloride Chemical Structure

Nicotinamide riboside chloride Chemical Structure

CAS No. : 23111-00-4

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Description

Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements[1].

IC50 & Target[1]

SIRT1

 

SIRT3

 

In Vitro

Nicotinamide riboside chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 nM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo

Chronic Nicotinamide riboside chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1].

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: p.o.; daily; for 16 weeks
Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner.
Molecular Weight

290.70

Formula

C₁₁H₁₅ClN₂O₅

CAS No.

23111-00-4

SMILES

NC(C1=C[N+]([[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]](O2)CO)O)O)=CC=C1)=O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (859.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4400 mL 17.1999 mL 34.3997 mL
5 mM 0.6880 mL 3.4400 mL 6.8799 mL
10 mM 0.3440 mL 1.7200 mL 3.4400 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Nicotinamide riboside chloride
Cat. No.:
HY-123033A
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