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    Epigenetics
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  3. Nicotinamide riboside malate

Nicotinamide riboside malate 

Cat. No.: HY-123033C
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Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.

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Nicotinamide riboside malate Chemical Structure

Nicotinamide riboside malate Chemical Structure

CAS No. : 2415659-01-5

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Description

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

IC50 & Target[1]

SIRT1

 

SIRT3

 

In Vitro

Nicotinamide riboside malate (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1].
Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM[1].
Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19[3].

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.5 nM
Incubation Time: 24 hours
Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo

Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner[1].

Animal Model: 10-week-old C57Bl/6J mice[1]
Dosage: 400 mg/kg
Administration: PO; daily; for 16 weeks
Result: Increased plasma and intracellular NAD+ content in a tissue-specific manner.
Molecular Weight

388.33

Formula

C₁₅H₂₀N₂O₁₀

CAS No.

2415659-01-5

SMILES

NC(C1=C[N+]([[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]](O2)CO)O)O)=CC=C1)=O.O[[email protected]](C(O)=O)CC([O-])=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Nicotinamide ribosideSirtuinNAD+oxidativemetabolismmetabolicabnormalitiesdietarysupplementsorallyvitaminB3niacinAlzheimer’sCOVID-19PARPInhibitorinhibitorinhibit

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Nicotinamide riboside malate
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HY-123033C
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