2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Stimulatory Immune Checkpoint Molecules
  5. B7-H2/ICOSLG

B7-H2/ICOSLG

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7324
    B7-H2/ICOSLG Protein, Human (HEK293, Fc)

    rHuB7-H2/ICOSLG, Fc Chimera; B7 homolog 2; B7RP-1; CD275

    		Human HEK293
    B7-H2/ICOSLG Protein, Human (HEK293, Fc) is a polypeptide chain containing the C-termimal human IgG1 Fc fragment produced in HEK293 cells. ICOSLG is a number of the B7 family of co-stimulatory molecules.
  • HY-P7325
    B7-H2/ICOSLG Protein, Human (HEK293, His)

    rHuB7-H2/ICOSLG, His; B7 homolog 2; B7RP-1; CD275

    		Human HEK293
    B7-H2/ICOSLG Protein, Human (HEK293, His) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells. ICOSLG is a number of the B7 family of co-stimulatory molecules.
  • HY-P78075
    B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi)

    CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50

    		Human HEK293
    B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Human (Biotinylated, HEK293, His-Avi) is 240 a.a., with molecular weight of 55-70 kDa.
  • HY-P73120
    B7-H2/ICOSLG Protein, Mouse (HEK293, His)

    ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

    		Mouse HEK293
    B7-H2/ICOSLG, a crucial ligand for T-cell receptor ICOS, mediates immune responses. It serves as a costimulatory signal, promoting T-cell and B-cell proliferation, cytokine secretion, and plasma cell differentiation. Beyond immune activation, it may influence local tissue responses during inflammation and modulate secondary immune responses. During pregnancy, B7-H2/ICOSLG favors an immunoprotective Th2 phenotype in maternal T-cells. It also interacts with CTLA4, contributing to intricate regulatory pathways of immune function. B7-H2/ICOSLG Protein, Mouse (HEK293, His) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Mouse (HEK293, His) is 233 a.a., with molecular weight of ~40-52 kDa.
  • HY-P75486
    B7-H2/ICOSLG Protein, Rat (HEK293, His)

    ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

    		Rat HEK293
    B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Rat (HEK293, His) is 261 a.a., with molecular weight of ~28.6 kDa.
  • HY-P76393
    B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His)

    ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

    		Cynomolgus HEK293
    The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is 256 a.a., with molecular weight of 50-70 KDa.
  • HY-P78392
    B7-H2/ICOSLG Protein, Human (HEK293, His-Avi)

    CD275; B7H2; B7-H2; B7RP-1; GL50; ICOSL; ICOS-L; ICOSLG; B7RP1; LICOS; ICOS ligand; B7-H2B7-related protein 1; B7RP-1; B7RP1B7-like protein Gl50

    		Human HEK293
    B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Human (HEK293, His-Avi) is the recombinant human-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Human (HEK293, His-Avi) is 240 a.a., with molecular weight of 55-70 kDa.
  • HY-P73119
    B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc)

    ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

    		Mouse HEK293
    B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses. It acts as a costimulatory signal, promoting T and B cell proliferation, cytokine secretion, and plasma cell differentiation. B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Mouse (HEK293, His-Fc) is 233 a.a., with molecular weight of 75-85 kDa.
  • HY-P75487
    B7-H2/ICOSLG Protein, Rat (HEK293, Fc)

    ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

    		Rat HEK293
    B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Rat (HEK293, Fc) is the recombinant rat-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H2/ICOSLG Protein, Rat (HEK293, Fc) is 261 a.a., with molecular weight of ~53.6 kDa.
  • HY-P76394
    B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc)

    ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

    		Cynomolgus HEK293
    B7-H2 is the ligand of Inducible Costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 interacted with CD28 in a non-overlapping domain. B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27kip1 and triggered signaling cascade of ERK and AKT kinases-dependent pathways. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is 256 a.a., with molecular weight of ~53.3 KDa.
Cat. No. Product Name Effect Purity