1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Other immune checkpoint molecules
  4. Siglec-9

Siglec-9 is a member of the Siglec family highly related to Siglec-7. Siglec-9 is expressed quite broadly among human blood leukocytes, including monocytes, neutrophils, B cells, NK cells, and minor subsets of T cells. Siglec-9, cross-talking with sialic acids (Sia) on the surface of target cells, can inhibit the cytotoxicity of NK cells. The interaction between Siglec-9 and Sia can lead to the phosphorylation of ITIM and recruit SHP-1 and SHP-2, which will suppress the NK cell activation. Siglec-9 is considered as a checkpoint member that exhibit inhibitory roles in regulating the immune balance.

Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name Effect Purity