2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. PD-1

PD-1

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Programmed death 1 (PD-1), also known as CD279, belongs to CD28 superfamily. PD-1 is an inhibitory receptor that is expressed on CD4+ and CD8+ T cells, NK cells, B cells, monocytes, and dendritic cells. PD-1 interacts with the ligands PD-L1 (B7-H1) and PD-L2 (B7-DC), which serves as a “rheostat” of immunological regulation, suppressing the activation and function of T cells to downregulate the immune response. PD-1 and its ligands play a fundamental role in the evasion of tumor cells from antitumor immunity. Moreover, PD-1 and PD-L1 is recognized as powerful targets to enhance tumor-directed cytotoxic T-cell function. In addition, PD-1/PD-L1 axis also regulates antiviral immune responses.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7395
    PD-1 Protein, Human (CHO, Fc)

    rHuPD-1, Fc Chimera; PD1; CD279; PDCD1

    		Human CHO
    PD-1 Protein, Human (CHO, Fc) suppress activating signals from the T cell receptor when bound by either of its ligands, programmed death-ligand 1 (PD-L1) or PD-L2.
  • HY-P7396
    PD-1 Protein, Human (143a.a, HEK293, His)

    rHuPD-1, His; PD1; CD279; PDCD1

    		Human HEK293
    PD-1 Protein, Human (143a.a, HEK293, His) suppress activating signals from the T cell receptor when bound by either of its ligands, programmed death-ligand 1 (PD-L1) or PD-L2.
  • HY-P70525
    PD-1 Protein, Human (HEK293, mFc)

    Programmed cell death protein 1; hPD-1; PDCD1; CD279

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (HEK293, mFc) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PD-1 Protein, Human (HEK293, mFc) is 147 a.a., with molecular weight of 55-70 kDa.
  • HY-P70766
    PD-1 Protein, Human (147a.a, HEK293, His)

    Programmed cell death protein 1; hPD-1; PDCD1; CD279

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (147a.a, HEK293, His) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PD-1 Protein, Human (147a.a, HEK293, His) is 147 a.a., with molecular weight of ~38.0 kDa.
  • HY-P70799
    PD-1 Protein, Human (C93S, HEK293, His)

    Programmed cell death protein 1; PDCD1; PD-1; hPD-1; CD279

    		Human HEK293
    PD-1 protein, an inhibitory receptor on T-cells, maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It hinders T-cell activation by associating with CD3-TCR and recruiting PTPN11/SHP-2 for dephosphorylation of key signaling molecules. Tumors exploit PD-1 to weaken anti-tumor immunity, inhibiting CTLs. Blocking PD-1 pathway reverses exhausted T-cell phenotype and enhances anti-tumor response, supporting cancer immunotherapy. PD-1 Protein, Human (C93S, HEK293, His) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-6*His labeled tag and C93S mutation. The total length of PD-1 Protein, Human (C93S, HEK293, His) is 143 a.a., with molecular weight of 23-38 kDa.
  • HY-P72406
    PD-1 Protein, Human (Biotinylated, HEK293, His-Avi)

    Programmed cell death protein 1; hPD-1; PDCD1; CD279

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of PD-1 Protein, Human (Biotinylated, HEK293, His-Avi) is 147 a.a., with molecular weight of 35-45 kDa.
  • HY-P73344
    PD-1 Protein, Human (HEK293, Fc)

    CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (HEK293, Fc) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Human (HEK293, Fc) is 143 a.a., with molecular weight of 55-66 kDa.
  • HY-P73345
    PD-1 Protein, Human (HEK293, His-Fc)

    CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (HEK293, His-Fc) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of PD-1 Protein, Human (HEK293, His-Fc) is 143 a.a., with molecular weight of 55-66 kDa.
  • HY-P73724
    PD-1 Protein, Mouse (HEK293, His-Fc)

    Programmed cell death protein 1; PD1; CD279; PDCD1

    		Mouse HEK293
    PD-1 (programmed cell death 1) protein negatively regulates immune responses and affects processes such as apoptosis and tolerance induction. It is a transmembrane protein found on the outside of the plasma membrane and expressed in the retina. PD-1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag. The total length of PD-1 Protein, Mouse (HEK293, His-Fc) is 143 a.a., with molecular weight of 60-65 kDa.
  • HY-P78191
    PD-1 Protein, Human (Biotinylated, HEK293, Fc-Avi)

    PDCD1; PD1; CD279; SLEB2; PD-1

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of PD-1 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 143 a.a., with molecular weight of 65-72 kDa.
  • HY-P73341
    PD-1 Protein, Canine (HEK293, Fc)

    CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2

    		Canine HEK293
    Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor which delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2, playing a critical role in induction and maintenance of immune tolerance to self. PDCD1 plays a role in anti-tumor immunity and is involved in safeguarding against autoimmunity, but PDCD1-mediated inhibitory pathway is also exploited by tumors to attenuate anti-tumor immunity. PD-1 Protein, Canine (HEK293, Fc) is the recombinant canine-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Canine (HEK293, Fc) is 146 a.a., with molecular weight of 55-70 kDa.
  • HY-P73347
    PD-1 Protein, Rat (HEK293, His)

    CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2

    		Rat HEK293
    Programmed cell death protein 1 (Pdcd1) is an immune-inhibitory receptor which delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2, playing a critical role in induction and maintenance of immune tolerance to self. Pdcd1plays a role in anti-tumor immunity and is involved in safeguarding against autoimmunity, but Pdcd1-mediated inhibitory pathway is also exploited by tumors to attenuate anti-tumor immunity. PD-1 Protein, Rat (HEK293, His) is the recombinant rat-derived PD-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PD-1 Protein, Rat (HEK293, His) is 143 a.a., with molecular weight of ~30-40 kDa.
  • HY-P77509
    PD-1 Protein, Human (Biotinylated, HEK293, His)

    Programmed cell death protein 1; hPD-1; PDCD1; CD279

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PD-1 Protein, Human (Biotinylated, HEK293, His) is 143 a.a., with molecular weight of ~17.4 KDa.
  • HY-P70639
    PD-1 Protein, Mouse (HEK293, Fc)

    Programmed cell death protein 1; PD-1; CD279; Pdcd1; mPD-1

    		Mouse HEK293
    The PD-1 protein is expressed on antigen-activated T cells and can induce and maintain immune tolerance to itself. PD-1 binds to CD274/PDCD1L1 and CD273/PDCD1LG2, transmits inhibitory signals, inhibits T cell activation and regulates immune responses. PD-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Mouse (HEK293, Fc) is 143 a.a., with molecular weight of ~61.66 kDa.
  • HY-P70640
    PD-1 Protein, Mouse (HEK293, His)

    Programmed cell death protein 1; PD-1; CD279; Pdcd1; mPD-1

    		Mouse HEK293
    The PD-1 protein is expressed on antigen-activated T cells and can induce and maintain immune tolerance to itself. PD-1 binds to CD274/PDCD1L1 and CD273/PDCD1LG2, transmits inhibitory signals, inhibits T cell activation and regulates immune responses. PD-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PD-1 Protein, Mouse (HEK293, His) is 143 a.a., with molecular weight of 32-40 kDa.
  • HY-P70676
    PD-1 Protein, Cynomolgus (147a.a, HEK293, His)

    Programmed cell death 1; PD-1; PD1

    		Cynomolgus HEK293
    PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (147a.a, HEK293, His) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PD-1 Protein, Cynomolgus (147a.a, HEK293, His) is 147 a.a., with molecular weight of 30-50 kDa.
  • HY-P73342
    PD-1 Protein, Canine (HEK293, His)

    CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2

    		Canine HEK293
    The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. PD-1 Protein, Canine (HEK293, His) is the recombinant canine-derived PD-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PD-1 Protein, Canine (HEK293, His) is 145 a.a., with molecular weight of ~34.88 and 65.02 kDa.
  • HY-P70547
    PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc)

    Programmed cell death 1; PD-1; PD1

    		Cynomolgus HEK293
    PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is 143 a.a., with molecular weight of 60-75 kDa.
  • HY-P73346
    PD-1 Protein, Human (167a.a, HEK293, His)

    CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2

    		Human HEK293
    PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (167a.a, HEK293, His) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PD-1 Protein, Human (167a.a, HEK293, His) is 143 a.a., with molecular weight of ~41.1 kDa.
  • HY-P700808
    PD-1 Protein, Mouse (Biotinylated, HEK293, Fc)

    PDCD1; PD1; CD279; SLEB2; PD-1

    		Mouse HEK293
    PD-1 (programmed cell death 1) protein negatively regulates immune responses and affects processes such as apoptosis and tolerance induction. It is a transmembrane protein found on the outside of the plasma membrane and expressed in the retina. PD-1 Protein, Mouse (Biotinylated, HEK293, Fc) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Mouse (Biotinylated, HEK293, Fc) is 143 a.a., with molecular weight of 60-70 kDa.
Cat. No. Product Name Effect Purity